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Preparation method of benzoyl peroxide gel

A technology of benzoyl peroxide gel and benzoyl peroxide, which is applied in the direction of active ingredients of peroxide compounds, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as benzene residues and lower product safety , to achieve the effect of improving the safety

Pending Publication Date: 2019-11-12
四川明欣药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, carcinogenic solvent (benzene) is used in the production process of carbomer 940 in most benzoyl peroxide prescriptions on the market, so that some benzene remains in commercial carbomer 940, thereby reducing the safety of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of benzoyl peroxide gel:

[0039] A prescription ingredient ratio of benzoyl peroxide gel is: main medicine: benzoyl peroxide (equivalent to pure) 5%, gel matrix: carbomer 9800.60%, wetting agent: propylene glycol 3%, surface Active agent: poloxamer 1880.1%, chelating agent: edetate disodium 0.1%, surfactant: docusate sodium 0.05%, suspending agent: colloidal silica 0.02%, adsorbent: acrylate copolymer (Polytrap 6603) 1.5%, humectant: glycerin 3%, pH regulator: sodium hydroxide 0.14% and solvent: purified water to make up to 100%;

[0040] A preparation method of benzoyl peroxide gel includes the following steps:

[0041] S10. Weigh out the raw and auxiliary materials according to the prescription and reserve them;

[0042] S20, prepare an aqueous phase for some raw and auxiliary materials;

[0043] S30. Perform gel phase preparation on some raw and auxiliary materials;

[0044] S40. Perform active phase preparation on some raw and auxiliary materials;

[004...

Embodiment 2

[0063] A preparation method of benzoyl peroxide gel:

[0064] A prescription ingredient ratio of benzoyl peroxide gel is: main medicine: benzoyl peroxide (equivalent to pure) 5%, gel matrix: carbomer 9800.80%%, wetting agent: propylene glycol 4%, Surfactant: poloxamer 1880.2%, chelating agent: disodium edetate 0.1%, surfactant: docusate sodium 0.05%, suspending agent: colloidal silica 0.03%, adsorbent: acrylate Copolymer (polytrap 6603) 2.0%, humectant: glycerin 4%, pH regulator: sodium hydroxide 0.14% and solvent: purified water to make up to 100%;

[0065] A preparation method of benzoyl peroxide gel includes the following steps:

[0066] S10. Weigh out the raw and auxiliary materials according to the prescription and reserve them;

[0067] S20, prepare an aqueous phase for some raw and auxiliary materials;

[0068] S30. Perform gel phase preparation on some raw and auxiliary materials;

[0069] S40. Perform active phase preparation on some raw and auxiliary materials;

[0070] S50. M...

Embodiment 3

[0088] A preparation method of benzoyl peroxide gel:

[0089] The prescription ingredient ratio of a benzoyl peroxide gel is as follows: main medicine: benzoyl peroxide (equivalent to pure) 5%, gel matrix: carbomer 9801.0%, wetting agent: propylene glycol 5%, surface Active agent: poloxamer 1880.3%, chelating agent: edetate disodium 0.1%, surfactant: docusate sodium 0.05%, suspending agent: colloidal silica 0.05%, adsorbent: acrylate copolymer (Polytrap 6603) 2.5%, humectant: glycerin 5%, pH regulator: sodium hydroxide 0.14% and solvent: purified water to make up to 100%;

[0090] A preparation method of benzoyl peroxide gel includes the following steps:

[0091] S10. Weigh out the raw and auxiliary materials according to the prescription and reserve them;

[0092] S20, prepare an aqueous phase for some raw and auxiliary materials;

[0093] S30. Perform gel phase preparation on some raw and auxiliary materials;

[0094] S40. Perform active phase preparation on some raw and auxiliary ma...

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PUM

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Abstract

The invention relates to the technical field of a medicinal preparation, and relates to a preparation method of a benzoyl peroxide gel. The prescription ingredient ratio of the benzoyl peroxide gel ischaracterized in that a main drug comprises 5% of benzoyl peroxide (based on pure basis), a gel matrix is 0.60% to 1.0% of carbomer 980, a wetting agent is 3% to 5% of propylene glycol, a surfactantis 0.1% to 0.3% of poloxamer 188, a chelating agent is 0.1% of disodium edetate, a surfactant is 0.05% of docusate sodium, a suspending agent is 0.02% to 0.05% of colloidal silica, an adsorbent is 1.5% to 2.5% of an acrylate copolymer (polytrap 6603), a humectants is 3 % to 5% of glycerin, a pH regulator is 0.14% of sodium hydroxide and a solvent, and purified water is supplied to 100%. The methodis characterized in that a carcinogenic solvent (benzene) is used in the production process of Carbomer 940, and a part of benzene remains in the commercial Carbomer 940, in the technical scheme, thecarbomer 980 is used instead of carbomer 940, and carbomer 980 does not contain benzene, so the product safety is improved.

Description

Technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of benzoyl peroxide gel. Background technique [0002] The original research company of benzoyl peroxide gel was Laboratoires Galderma, which was approved to be marketed in France on March 19, 1986. The trade name is CUTACNYL, and the specifications are 5% and 10%. In July of the same year, it was listed with 2.5% specifications. Currently, there is no unilateral listing in the United States, Japan approved the listing in 2014, and China has original imported varieties. [0003] In December 2014, Japan approved Maruho Co., Ltd's benzoyl peroxide gel to be marketed, with specifications of 2.5%, 15g and 30g. This is the first time that benzoyl peroxide has been used to treat acne vulgaris in Japan. However, carbomer 940 in most benzoyl peroxide prescriptions on the market currently uses carcinogenic solvent (benzene) in the production process, so ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/327A61K47/10A61K47/32A61P17/10
CPCA61K31/327A61K9/06A61K47/32A61K47/10A61P17/10
Inventor 朱锋华文永安王静
Owner 四川明欣药业有限责任公司
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