164results about "Peroxy compound active ingredients" patented technology

The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

The invention provides benzoyl peroxide gel and a preparation method thereof. The preparation method comprises the following steps: S1, preparing an active phase; s2, preparing a gel phase; s3, mixing half of the active phase with the gel phase, and performing constant-temperature water bath to obtain low-crosslinking-degree gel; s4, uniformly granulating the low-crosslinking-degree gel, mixing the low-crosslinking-degree gel with the balance of the active phase, and performing vacuum negative-pressure stirring twice to obtain a material; and S5, adding a pH regulator into the material, regulating the pH value, discharging and filling. Nanocrystals are formed through benzoyl peroxide pretreatment, the surface area and activity are improved, the curative effect is enhanced on the premise of safety, uniform dispersion can be achieved, the stability of benzoyl peroxide in gel is improved, and the storage time is prolonged. A part of the active phase and the gel phase are mixed to form low-crosslinking-degree gel, the low-crosslinking-degree gel is uniformly granulated and then mixed with the remaining active phase, and the benzoyl peroxide gel is prepared through vacuum negative pressure, so that the swelling property can be improved, the stability and the permeability can be improved, and adverse reactions such as irritation to skin can be avoided.

An animal watering system is disclosed. The animal watering system comprises an activated water source and an animal watering station configured to receive activated water from the activated water source. The activated water source comprises a unipolar electrolytic cell configured to produce activated water containing a desired amount of hydrogen peroxide. A methane conversion system comprising an activated water source and a mixer for contacting activated water from the activated water source with a gas containing methane and with a source of Fe2+ ions is also disclosed.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

Excipient granulations containing a viscosifying agent, a disintegrant, and one or more additional excipients are disclosed. An excipient granulation can be combined with a pharmaceutical granulation to provide a pharmaceutical composition. The excipient granulations can be used to increase the viscosity of an aqueous composition such as an oral pharmaceutical composition. When added to an aqueous solution, the excipient granulation can dissolve to provide a suspension of the pharmaceutical granules in a viscous solution. The excipient granulation can be used to improve the palatability of oral pharmaceutical compositions containing a pharmaceutical granulation.

The present invention relates to the use of glycoalkaloids, such as solasonine and solamargine, in treatment of cancer such as skin cancer, and to compositions for use in such treatment. More particularly the present invention relates to providing an improved, substantially stable formulation for the glycoalkaloids which minimises or reduces degradation of these active molecules.

COACERVAT CLEANSING COMPOSITION WITH ACNE TREATMENT ACTIVE The disclosure relates to compositions comprising (a) at least one amphoteric surfactant, (b) at least one glycolipid, (c) at least one cationic polymer at a concentration of approximately 0.05% to approximately 2%; (d) at least one acne treatment active, and (e) at least one cosmetically acceptable solvent, in which the cleansing system is substantially free of phenoxyethanol, and in which the pH of the composition is between approximately 4 and approximately 8, and in which the weight ratio of a to b is approximately 0.4 to approximately 4, and in which the combined concentration of a and b is approximately 10% to approximately 20% of the total weight of the composition. The compositions may be used as rinse-off compositions to cleanse the skin and deposit acne treatment actives. Figure for the abstract: none

The present invention relates to a new multifunctional debridement and / or antifouling composition comprising H2O2 at a final concentration of between 0.1-5% v / v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40% w / v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and / or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

Compositions and methods for treating solid cancer are provided. Specifically, the disclosure provides compositions comprising haloperoxidases, and methods comprising administering such compositions, for treating solid cancer.

The invention discloses a method for preparing benzoyl peroxide gel and application, and belongs to the technical field of medicine preparation. The preparation method comprises the following steps: preparing a ternary eutectic solvent by taking choline chloride, glycerol and benzoic acid as raw materials, mixing benzoyl peroxide with the ternary eutectic solvent to obtain a benzoyl peroxide system, and mixing the benzoyl peroxide system with a gel system on the basis to prepare the benzoyl peroxide gel with relatively high stability, storage stability and antibacterial activity.

The present disclosure relates to compositions and methods useful for dietary augmentation to provide therapeutic intervention for the treatment and management of acne-prone skin. According to one embodiment of the present disclosure, there is provided an orally administrable composition containing a therapeutically effective amount of: (a) pantothenic acid; (b) folic acid; (c) myo-inositol; (d) methylsulfonylmethane (MSM); (e) holy basil extract; (f) optionally, turmeric root extract; (g) barberry root extract; (h) L-theanine; and (i) milk thistle extract.

The present disclosure relates to the treatment of skin condition in a subject, including acne vulgaris, comprising applying to the skin of the subject a first composition comprising Spongilla, and a second composition comprising one or more fluidizing agents, such as water, saline or a hydrogen peroxide solution. The disclosure also relates to a products or kits for the treatment of skin conditions in a subject, including acne vulgaris, comprising Spongilla, and a second composition comprising one or more fluidizing agents, such as water, saline or a hydrogen peroxide solution, such as a 3% by weight solution of hydrogen peroxide.

The invention discloses a minocycline and benzoyl peroxide pharmaceutical composition as well as a preparation method and application thereof, and relates to the technical field of medicines. The invention relates to a pharmaceutical composition of minocycline and benzoyl peroxide. The pharmaceutical composition comprises minocycline hydrochloride silicon dioxide sustained-release microcapsules, benzoyl peroxide silicon dioxide sustained-release microcapsules and pharmaceutic adjuvants. According to the invention, minocycline and benzoyl peroxide are combined for use and are prepared into a sustained-release microcapsule structure, so that the treatment effect after medicine combination is obviously superior to that of single use of antibiotics or benzoyl peroxide, and an obvious synergistic effect is achieved; minocycline and benzoyl peroxide are respectively prepared into silicon dioxide sustained-release microcapsule structures and then are combined, so that the stability of the medicine can be improved, the direct contact between the medicine and the skin can be avoided, and the irritation of the medicine to the skin is reduced; active ingredients are prepared into a sustained-release microcapsule structure, so that the medicine can be slowly released when being in contact with skin, and different sustained-release requirements can be met.

An acne treatment composition that contains a mixture of rhamnolipid salts is disclosed. The composition has efficacy against C. acnes. Also disclosed is a method for controlling, treating, or preventing acne in a subject.

Compositions and methods for treating alopecia, particularly chemotherapy-induced alopecia, using oxidizers or oxidants, pro-oxidant compounds, or activators of P53. Compositions comprising organic peroxides such as, cumene hydroperoxide, tert-Butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. Compositions may be applied subcutaneously, percutaneously, or topically. Most preferably, the compositions are applied to a treatment area prior to a round of chemotherapy to prevent or reduce hair loss in the treatment area.

The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises a medicine granulated substance containing 4-((L-valyl) oxy) butyric acid and an excipient granulated substance. When the pharmaceutical composition is combined and mixed with water, the excipient particles rapidly dissolve to form a viscous solution in which the pharmaceutical granules are suspended. The pharmaceutical granulate provides a palatable oral pharmaceutical composition.

Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and / or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.

The present application relates to regimens, methods of treatment, and compositions for treating acne in a subject suffering from acne.

Provided is a benzoyl peroxide-containing composition that has smaller change in viscosity over time and can be easily removed from the skin. This skin composition comprises: (A) benzoyl peroxide; (B) an acrylamide-(sodium acryloyldimethyltaurate) copolymer; (C) a surfactant comprising at least one selected from the group consisting of (c1) a combination of sodium lauroyl sarcosinate and at least one anionic surfactant and / or nonionic surfactant, (c2) at least one anionic surfactant selected from the group consisting of sodium lauryl sulfate, polyoxyethylene alkyl ether phosphates, polyoxyethylene alkyl ether sulfates, and sodium lauroyl glutamate, and (c3) a combination of sodium oleate and at least one anionic surfactant and / or nonionic surfactant; and (D) at least one water-based solvent selected from among water and a water-soluble solvent. The skin composition is used by being applied to an affected area of the skin, left to stand for a predetermined time, and subsequently removed from the affected area.

The present invention relates to formulations containing active oxygen compounds, including active oxygen and other active ingredients, for the care and / or maintenance and maintenance of the health of the skin and integumentary system on the surface of the body and in the ears of an organism, as well as the oral cavity, including the mucous membranes, teeth, dental cavities, and periodontal tissues (gums) within the oral cavity, i.e., the care and / or maintenance and maintenance of the health of target areas of an organism. Formulations for the skin and integumentary system on the surface of the body and in the ears and the oral cavity, including the mucous membranes, teeth, dental cavities, and periodontal tissues (gums), are in the form of solutions, gels, emulsions, lotions, milks, sprays, creams, film dressings, liposomes, and / or micelles. Formulations for the oral cavity, including the teeth, dental cavities, and periodontal tissues (gums), and related systems and structures are in the form of solutions, mouthwashes, sprays, gels, pastes, emulsions, film dressings, liposomes, and / or micelles. These formulations are included in devices that apply the formulations to or into the above areas of an organism.

Disclosed herein are shelf-stable formulations comprising benzoyl peroxide in a formulation effective to reduce or prevent degradation of the benzoyl peroxide to benzene. Further provided herein are methods of preventing or reducing degradation of benzoyl peroxide to benzene in a drug product, as well as methods of identifying drug products containing benzoyl peroxide that form high levels of benzene.

Disclosed is a method for treating skin. The method can include topically applying to skin in need thereof a composition comprising effective amounts of Arctium lappa root extract and Epilobium angustifolium extract to reduce expression of a pro-inflammatory cytokine of IL-8, IL-2, or TNF-α in the skin.

The present invention relates to a new multifunctional debridement and / or antifouling composition comprising H2O2 at a final concentration of between 0.1 - 5%v / v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40%w / v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and / or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

A three-dimensional oxygen-generating bioscaffold capable of supplying cells with a continuous, controlled, and steady source of oxygen and methods of using such an oxygengenerating bioscaffold to prevent hypoxia-induced damage to cells following transplantation are disclosed. In particular, a collagen-based cryogel bioscaffold having calcium peroxide (CPO) incorporated into its matrix is provided, wherein the CPO produces oxygen upon exposure to water. The collagen-based cryogel is designed with a plurality of macropores capable of encapsulating therapeutic cells for cellular therapy. Methods of producing oxygen-generating bioscaffolds and tissue grafts comprising therapeutic cells contained in such oxygen-generating bioscaffolds as well as their use in cellular therapy are also disclosed.

Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and / or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.

Provided are a peroxide-containing liposome, a preparation method therefor, and use thereof. The peroxide-containing liposome is a spherical vesicle having a double-layer membrane structure and formed by lipid molecules containing one or more peroxy groups, and the lipid molecules contain carbon-carbon double bonds. The peroxide-containing liposome can be obtained by mixing peroxide-containing lipid molecules with an aqueous system, wherein the peroxide-containing lipid molecules are obtained by reacting unsaturated lipid molecules containing -CH=CH- and / or -C≡C- with an additive in the presence of oxygen and a solvent, and the additive is selected from one or more of lipoxygenase, an oxidation catalyst, and an oxidizing agent. By means of in-vitro experiments in cells and in-vivo experiments in animals, it is found that the peroxide-containing liposome can kill tumor cells and can be used as a sensitizing agent in combination with other tumor treatment methods to effectively improve the therapeutic effect on tumors, thus having good application prospects in resisting tumors.

The invention discloses tooth whitening gel and a preparation method thereof, and relates to the technical field of tooth gel. The toothpaste comprises the following components: 2% of sodium carboxymethyl cellulose, 10% of glycerol, 4% of polyethylene glycol-400, 6% of urea peroxide, 1% of potassium nitrate, 0.5% of menthol, 3% of xylitol, a pH regulator for regulating the pH value to 6.5, and the balance of deionized water. The urea peroxide realizes nanoscale dispersion under a low-temperature wet grinding process, and cooperates with the potassium nitrate to block neural signal conduction through an ion channel, so that the whitening effect and dentin sensitivity problems are synchronously solved; xylitol can reduce irritation and form a'whitening-desensitization 'synergistic system; a three-time equal-component feeding method is combined with temperature control, so that sodium carboxymethyl cellulose is fully swelled and forms a stable net-shaped structure, and the caking defect caused by traditional one-time feeding is avoided.