Method for preparing docusate sodium soft capsules

Abstract

The invention discloses a method for preparing docusate sodium soft capsules, which comprises the following steps: A, preparing red gelatin solution, i.e. dissolving a plasticizer into water, adding the obtained product into a gelatin melting tank, heating to a temperature of 40 to 80 DEG C, adding gelatin, stirring to dissolve the gelatin to obtain gelatin solution, adding a colorant I into the water, uniformly stirring, adding the mixture into the gelatin solution, stirring, vacuumizing and discharging air bubbles to obtain the red gelatin solution for later use; B, preparing white gelatin solution, i.e. adding an additive into the sufficient quantity of water, uniformly dispersing by a colloid mill to obtain solution I, dissolving the plasticizer into the water, adding the solution I and the plasticizer solution into the gelatin melting tank to heat to a temperature of 40 to 80 DEG C, adding gelatin, stirring and dissolving the gelatin, and after totally dissolving the gelatin, vacuumizing and discharging air bubbles to obtain the white gelatin solution for later use; C, preparing contents, i.e. adding polyhydric alcohol into polyethylene glycol solution of docusate sodium and uniformly mixing at a temperature of 30 to 50 DEG C to obtain the contents for later use; and D, preparing the soft capsules, i.e. adding the content liquor obtained in the step C into a feed hopper of a pelleting press, regulating packing volumes and thickness of shells, pelleting, drying, smearing pills and packaging.

Description

technical field [0001] The invention relates to a preparation method of docusate sodium soft capsules. Background technique [0002] Chronic functional constipation is one of the more common gastrointestinal diseases in clinical practice, which is caused by the abnormal function of the colon, rectum and anus, resulting in decreased stool frequency or intractable dry stool. Local and general discomfort Chronic constipation can cause local and systemic symptoms, such as bitter mouth, sticky mouth, epigastric fullness, hypochondriac pain, belching, and some patients may also experience loss of appetite, listlessness, dizziness, fatigue, general malaise, and headache , insomnia, etc. Constipation can cause local harm to the body and directly cause anorectal diseases. If it is not treated in time, it will seriously endanger the quality of life of patients. Therefore, maintaining stool moisture and increasing stool volume is a better way to treat constipation in the elderly. Cli...

AI Technical Summary

Problems solved by technology

Clinically used bulky laxatives such as polyethylene glycol 4000 and lubricating laxatives such as liquid paraffin have poor taste and weak effects, and can cause absorption disorders of vitamins A, D, K, calcium and phosphorus; and long-term use Stimulant laxatives, such as Chinese medicine rhubarb or similar ingredients, can ...

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