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Method for preparing docusate sodium soft capsules

A kind of technology of docusate sodium and soft capsule

Active Publication Date: 2013-05-01
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically used bulky laxatives such as polyethylene glycol 4000 and lubricating laxatives such as liquid paraffin have poor taste and weak effects, and can cause absorption disorders of vitamins A, D, K, calcium and phosphorus; and long-term use Stimulant laxatives, such as Chinese medicine rhubarb or similar ingredients, can cause patients to become dependent on the drug, and damage the nerves of the intestinal wall, leading to melanosis of the colon, which in turn may cause colon cancer, so it is not suitable for long-term use
The existing technology for preparing docusate sodium soft capsules is relatively complicated, which is not conducive to production

Method used

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  • Method for preparing docusate sodium soft capsules
  • Method for preparing docusate sodium soft capsules
  • Method for preparing docusate sodium soft capsules

Examples

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preparation example Construction

[0030] The preparation method comprises the following steps:

[0031] A. Preparation of red gelatin solution

[0032] Dissolve the plasticizer in water, add it into the glue tank and heat it to 40-80°C, add gelatin, stir and dissolve at 60-80°C to obtain a gelatin solution, add the colorant I to the water, stir evenly, and obtain the pigment solution, add the pigment solution into the gelatin solution, stir and vacuumize to remove air bubbles, and set aside; the weight ratio of water and gelatin is 0.8~1.2:1.

[0033] B. Preparation of white gelatin solution

[0034] Add the additives into a sufficient amount of water, disperse the colloid mill evenly, and obtain the solution I, dissolve the plasticizer in water, add the solution I and the plasticizer solution into the glue tank and heat to 40-80°C, add gelatin, 60-80°C Stir to dissolve at ℃. After the solution is complete, vacuum to remove air bubbles and set aside; the weight ratio of water to gelatin is 0.8~1.2:1.

[003...

Embodiment 1

[0041] The present invention prepares the method for docusate sodium soft capsule, and this docusate sodium soft capsule comprises the two-color soft capsule rubber skin that is made of red gelatin liquid and white gelatin liquid, and docusate sodium is housed in the two-color soft capsule rubber skin Contents, wherein the content of docusate sodium in the finished product of docusate sodium soft capsule consists of the following components by weight percentage:

[0042] Docusate Sodium 10%

[0043] Polyethylene glycol 80%

[0044] Polyol 15%;

[0045] The red rubber consists of the following components by weight percentage:

[0046]

[0047] The white rubber consists of the following components by weight percentage:

[0048]

[0049] The preparation method comprises the following steps:

[0050] A. Preparation of red gelatin solution

[0051] Dissolve the plasticizer in water, add it into the glue tank and heat it to 40°C, add gelatin, stir and dissolve at 60°C to ...

Embodiment 2

[0060] The present invention prepares the method for docusate sodium soft capsule, and this docusate sodium soft capsule comprises the two-color soft capsule rubber skin that is made of red gelatin liquid and white gelatin liquid, and docusate sodium is housed in the two-color soft capsule rubber skin Contents, wherein the content of docusate sodium in the finished product of docusate sodium soft capsule consists of the following components by weight percentage:

[0061] Docusate Sodium 50%

[0062] Polyethylene glycol 35%

[0063] Polyol 15%;

[0064] The red rubber consists of the following components by weight percentage:

[0065]

[0066] The white rubber consists of the following components by weight percentage:

[0067]

[0068] The preparation method comprises the following steps:

[0069] A. Preparation of red gelatin solution

[0070] Dissolve the plasticizer in water, add it into the glue tank and heat it to 80°C, add gelatin, stir and dissolve at 80°C to ...

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Abstract

The invention discloses a method for preparing docusate sodium soft capsules, which comprises the following steps: A, preparing red gelatin solution, i.e. dissolving a plasticizer into water, adding the obtained product into a gelatin melting tank, heating to a temperature of 40 to 80 DEG C, adding gelatin, stirring to dissolve the gelatin to obtain gelatin solution, adding a colorant I into the water, uniformly stirring, adding the mixture into the gelatin solution, stirring, vacuumizing and discharging air bubbles to obtain the red gelatin solution for later use; B, preparing white gelatin solution, i.e. adding an additive into the sufficient quantity of water, uniformly dispersing by a colloid mill to obtain solution I, dissolving the plasticizer into the water, adding the solution I and the plasticizer solution into the gelatin melting tank to heat to a temperature of 40 to 80 DEG C, adding gelatin, stirring and dissolving the gelatin, and after totally dissolving the gelatin, vacuumizing and discharging air bubbles to obtain the white gelatin solution for later use; C, preparing contents, i.e. adding polyhydric alcohol into polyethylene glycol solution of docusate sodium and uniformly mixing at a temperature of 30 to 50 DEG C to obtain the contents for later use; and D, preparing the soft capsules, i.e. adding the content liquor obtained in the step C into a feed hopper of a pelleting press, regulating packing volumes and thickness of shells, pelleting, drying, smearing pills and packaging.

Description

technical field [0001] The invention relates to a preparation method of docusate sodium soft capsules. Background technique [0002] Chronic functional constipation is one of the more common gastrointestinal diseases in clinical practice, which is caused by the abnormal function of the colon, rectum and anus, resulting in decreased stool frequency or intractable dry stool. Local and general discomfort Chronic constipation can cause local and systemic symptoms, such as bitter mouth, sticky mouth, epigastric fullness, hypochondriac pain, belching, and some patients may also experience loss of appetite, listlessness, dizziness, fatigue, general malaise, and headache , insomnia, etc. Constipation can cause local harm to the body and directly cause anorectal diseases. If it is not treated in time, it will seriously endanger the quality of life of patients. Therefore, maintaining stool moisture and increasing stool volume is a better way to treat constipation in the elderly. Cli...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/22A61K47/42A61P1/10
Inventor 毛万祥贾卫东张丁酉
Owner 安士制药(中山)有限公司
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