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Polycaprolactone-graphene oxide composite porous scaffold material preparation method

A graphene composite, polycaprolactone technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of lack of biorecognizable sites, poor hydrophilicity, low mineralization activity, etc., to improve osteogenesis Cytocompatibility and osteogenic activity, high porosity, good biocompatibility

Pending Publication Date: 2017-04-26
袁峰 +1
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Problems solved by technology

[0004] In order to solve the problems of poor hydrophilicity, low mineralization activity and lack of biorecognizable sites of polycaprolactone-graphene oxide composite porous scaffold materials produced by traditional devices, the purpose of the present invention is to provide a polycaprolactone A method for preparing an ester-graphene oxide composite porous scaffold material. The porous scaffold material produced by the method has the advantages of high porosity, interconnected pores, good biocompatibility, and osteogenic inductive activity; the porous scaffold has the advantages of high porosity At the same time, it shows good mechanical and biological properties

Method used

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preparation example Construction

[0013] A preparation method of a polycaprolactone-graphene oxide composite porous scaffold material, the preparation method comprising the following steps:

[0014] (1) Dissolve graphene oxide and docusate sodium sodium salt in dimethylformamide at the same time, ultrasonically pulverize at room temperature until completely dispersed, and stir evenly to obtain a certain concentration of graphene oxide / docusate sodium sodium salt dispersion liquid;

[0015] (2) Polycaprolactone is dissolved in the mixed solution of dichloromethane and docusate sodium sodium salt, and magnetically stirred at room temperature until it is evenly mixed to obtain a certain concentration of polycaprolactone / (dichloromethane and docusate Sodium sodium salt) solution;

[0016] (3) Graphene oxide solution and polycaprolactone solution are mixed in proportion, stirred and mixed, obtain polycaprolactone-graphene oxide solution;

[0017] (4) After the above-mentioned mixed liquid is ultrasonically treate...

Embodiment 1

[0028] In this example, a graphene oxide solution was prepared using docusate sodium sodium salt as a surfactant, and a polycaprolactone-graphene oxide composite porous scaffold material was prepared by electrospinning technology:

[0029] Step 1: Dissolve 0.06g of graphene oxide and 0.005g of docusate sodium salt in 10ml of dimethylformamide at the same time, ultrasonically pulverize at room temperature until completely dispersed, and stir evenly to obtain a concentration of 6mg / ml graphene oxide / docusate sodium salt dispersion liquid;

[0030] Step 2: Dissolve 1.12g of polycaprolactone in 8ml of a mixture of dichloromethane and docusate sodium sodium salt (volume ratio 1:1), stir at room temperature until uniformly mixed, and obtain a concentration of 140mg / ml of polycaprolactone solution;

[0031] Step 3: mixing the graphene oxide solution and the polycaprolactone solution at a mass ratio of 0.2%, stirring and mixing to obtain a polycaprolactone-graphene oxide solution; ...

Embodiment 2

[0034] In this example, a graphene oxide solution was prepared using docusate sodium sodium salt as a surfactant, and a polycaprolactone-graphene oxide composite porous scaffold material was prepared by electrospinning technology:

[0035] Step 1: Dissolve 0.08g of graphene oxide and 0.006g of docusate sodium sodium salt in 10ml of dimethylformamide at the same time. At room temperature, ultrasonically pulverize until completely dispersed, and stir evenly to obtain a concentration of 8mg Graphene oxide / docusate sodium sodium salt dispersion liquid of / ml;

[0036] Step 2: Dissolve 1.28g of polycaprolactone in a mixed solution of 8ml of dichloromethane and docusate sodium sodium salt (volume ratio of 1:0.9), magnetically stir overnight at room temperature, and configure the concentration to be 160% ( W / V) homogeneous polycaprolactone / (methylene chloride and docusate sodium sodium salt) solution;

[0037] Step 3: mixing the graphene oxide solution and the polycaprolactone solut...

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Abstract

The invention relates to a polycaprolactone-graphene oxide composite porous scaffold material preparation method, which comprises: (1) simultaneously dissolving graphene oxide and docusate sodium into dimethylformamide to obtain a graphene oxide / docusate sodium dispersion liquid; (2) dissolving polycaprolactone into the mixed liquid of dichloromethane and docusate sodium to obtain a polycaprolactone / (dichloromethane and docusate sodium) solution; (3) mixing the graphene oxide solution and the polycaprolactone solution to obtain a polycaprolactone-graphene oxide solution; and (4) carrying out ultrasonic treatment on the obtained mixed liquid, loading into the syringe of an electrospinning machine, carrying out electrospinning, and carrying out freeze drying on the composite nanometer fiber obtained from the electrospinning to obtain the polycaprolactone-graphene oxide composite porous scaffold material. According to the present invention, the polycaprolactone-graphene oxide composite porous scaffold material prepared through the method has advantages of high porosity, pore communication, good biocompatibility, osteogenic inducing activity, and the like; and with the preparation method, the porous scaffold has the high porosity while the good mechanical and biological properties are provided.

Description

technical field [0001] The invention relates to a preparation method of a composite porous support material, in particular to a preparation method of a polycaprolactone-graphene oxide composite porous support material. Background technique [0002] Polycaprolactone is a biodegradable biomaterial with good biocompatibility. PCL has attracted much attention in the field of bone repair materials because of its low cost, excellent plastic processability, and stable initial mechanical strength. At present, a large number of basic research and animal experimental research on polycaprolactone materials have been carried out at home and abroad, and good results have been achieved in bone tissue engineering scaffolds, and some products have been used clinically. [0003] However, existing studies have shown that the osteogenic activity of polycaprolactone in bone defects is limited due to its poor hydrophilicity, low mineralization activity, and lack of biorecognizable sites. Theref...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/18A61L27/08A61L27/50
CPCA61L27/08A61L27/18A61L27/50A61L27/56A61L2430/02C08L67/04
Inventor 袁峰高鹏李威张腾沃金孙玛骥彭琨翔朱俊陈鹏宇姜伟
Owner 袁峰
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