Medical preparation for treating astriction and preparation method thereof

Abstract

The invention relates to a medical preparation for treating astriction and a preparation method thereof. The invention is characterized in that: a suppository for rectal administration is prepared by adding a base material and a proper dispersant into docusate sodium; the quality of the suppository is controllable; the product is stable; the natural of the product is mild; the product can be used for preventing and treating various kinds of astriction, such as astriction caused by hemorrhoids, age and weakness and cerebrovascular diseases and astriction occurring after anal and gynecological operations and other operations, in people of different ages; and the product has a particular clinic application value for patients who cannot bear taking medicaments orally or special patients.

Description

technical field [0001] The invention relates to a docusate sodium suppository and a preparation method thereof. Background of the invention [0002] Constipation is a kind of commonly encountered diseases, frequently-occurring disease, is to be the disease of main symptom with the constipation of defecation, difficulty in defecation. It can be caused by a variety of different pathological processes, resulting in the conduction dysfunction of the large intestine, the stool stays in the intestine for too long, and the water is absorbed, resulting in difficulty in defecation. In addition, the recovery period of intestinal inflammation, postoperative, postpartum, and adverse drug reactions can also cause temporary constipation. Constipation not only affects people's quality of life, but also brings trouble and inconvenience to life. It can also cause other diseases, especially the cardiovascular and cerebrovascular diseases of middle-aged and elderly people. People are always...

AI Technical Summary

Problems solved by technology

We believe that the disadvantage of this patent is that in the production process, rhubarb and Glauber's salt are added to the substrate at a temperature of 60-90°C and stirred, and the control of cooling time is lacking in the production. The effect of sennoglycogen A decreases with the increase of temperature and the extension of time, and there is a problem that the activity of the drug decreases; secondly, rhubarb and mirabilite are cold drugs, "repelling down to attack fire" and "attacking dryness in the intestines". "It is often used for constipation in adults, but it is not suitable for patients after surgery or children, etc.

[0004] When docusate sodium is mixed with a water-soluble base or a fat-soluble base or both bases to prepare suppositories, there is a problem of uneven drug solution. After mixing, the product has precipitation and color difference, which affects the drug content uniformity and appearance of the suppository after pouring. Conducive to drug production control and product application

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