Medical preparation for treating astriction and preparation method thereof
A technology for treating constipation and pharmaceutical preparations, applied in the field of docusate sodium suppositories and their preparation, can solve problems such as unfavorable drug production control and product application, influence on suppository drug content uniformity and appearance, decrease in drug activity and the like
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Embodiment 1
[0012]
[0013] Operation: semi-synthetic fatty acid glycerides plus docusate sodium are completely melted when heated to 50°C, hydrogenated palm kernel oil is continuously stirred, and the matrix is completely melted with residual heat, stirred evenly, and poured when the mixture is cooled to 40°C. The mold can be cooled at 0-4°C for 2-3 minutes in advance. After pouring for 5 minutes, scrape it flat, and release the mold after 10 minutes. The temperature during injection molding can be controlled at about 40°C.
Embodiment 2
[0015]
[0016] Operation: Heat hydrogenated palm kernel oil and polyethylene glycol at 20000°C, start to melt at 38°C, and completely melt at 48°C, add docusate sodium and magnesium oxide and stir evenly, cool the mixture to about 38°C (that is, before solidification) and pour. Pouring, cooling, leveling, and mold removal.
Embodiment 3
[0018]
[0019] Operation is the same as embodiment 2
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