42 results about "Cornea surface" patented technology

A cornea is reshaped by first creating a first cut in the cornea using an ultra-short pulse laser. The first cut is located below the surface of the cornea and does not extend through the epithelium. A second cut is then created using the ultra-short pulse laser. The second cut creates a corneal flap and intersects with the first cut to create a substantially severed portion of the cornea located between the first cut and the second cut. The severed portion of the cornea is located outside of the visual axis of the eye. The corneal flap is lifted away from the severed portion, and the severed portion is removed from the eye. The corneal flap is moved into the space on the cornea previously occupied by the severed portion. The cornea is thereby reshaped, and the reshaped portion of the cornea has an increased refractive power, correcting for hyperopic and presbyopic conditions.

A shape change is induced in a cornea for treating a keratoconus condition, and / or correcting a refractive error and / or a high order aberration. A beam of laser pulses is focused to a stromal layer of a patient's eye, and an intrastromal pocket is ablated. An injection port is cut between the intrastromal pocket and a cornea surface of the eye. A polymerizable fluid is flowed into the intrastromal pocket through the injection port. The fluid is cured to form a polymeric insert, and thereby inducing a cornea shape change.

A method of generating three dimensional shapes for a cornea and lens, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of the eye based on the multiple sections of light. For each obtained multiple sectional image, the following processes are performed:a) automatically identifying arcs corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the obtained multiple sectional images; andb) determining an intersection of lines ray traced back from the identified arcs with a known position of a section of space containing the section of light that generated the obtained multiple sectional images, wherein the intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the cornea surfaces and the lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.

Methods, devices, and systems for reprofiling a surface of a cornea of an eye ablate a portion of the cornea to create an ablation zone with an optically correct central optical zone disposed in a central portion of the cornea, and a blend zone disposed peripherally to the central optical zone and at least partially within an optical zone of the eye. The blend zone can have an optical power that gradually diminishes with increasing radius from the central optical zone.

Systems and methods for treating a tissue of an eye with a laser beam include at least one processor that determines angles between a curved surface and a laser beam, controlling an ablative treatment in response to the angles. Angles between a surface of a cornea and a laser beam may be mapped over a treatment area. A mapped area may include an apex of a cornea displaced from a center of a pupil of an eye. Ablation properties may be determined locally in response to the incident angle of a laser beam with respect to a local slope of a tissue surface. The treatment area may be ablated using local ablation properties to form a desired surface shape.

The present invention provides an opthalmologic apparatus that can noninvasively measure the state of the lacrimal layer formed on the cornea surface and that can quantitatively measure the state of the lacrimal layer without utilizing a reflection image from the retina.The opthalmologic apparatus according to the present invention comprises an optical projection system for projecting light of a specified pattern onto a cornea surface, and an imaging device for photographing a reflection image of the projected light from the cornea surface. An operating unit calculates the degree of distortion of the reflection image on the basis of the density value distribution of the image photographed by the imaging device. The operating unit can determine the state of the lacrimal layer using the calculated degree of distortion.

The invention relates to a design method of free-form surface glasses based on a wave-front technology, which has the technical characteristics that length data of each part of an eye axis is substituted into an eye optical model; a cornea surface curvature and a corneal topography data replace the eye model; wave-front aberration data of actual human eyes is converted into a corresponding value under photopic vision; an individualized eye model which accords with an actual human eye visual property is established; a lens is arranged in front of the individualized eye model; the lens and the individualized eye model are considered as a uniform lens-eye optical system and a certain visual field angle is arranged for the system; a plurality of structures with different angles are arranged for the lens-eye optical system; and the free-form surface glasses according with an individual eye visual property, and the diopter and the structural parameters thereof are calculated. The free-form surface lens obtained by the design method disclosed by the invention, low-order aberration of the eyes can be corrected and high-order aberration can be better corrected; and the design method has the advantages of simplicity and convenience for designing, objectiveness and accuracy, and high precision.

The present invention provides an ophthalmologic apparatus that can noninvasively measure the state of the lacrimal layer formed on the cornea surface and that can quantitatively measure the state of the lacrimal layer without utilizing a reflection image from the retina.The ophthalmologic apparatus according to the present invention comprises an optical projection system for projecting light of a specified pattern onto a cornea surface, and an imaging device for photographing a reflection image of the projected light from the cornea surface. An operating unit calculates the degree of distortion of the reflection image on the basis of the density value distribution of the image photographed by the imaging device. The operating unit can determine the state of the lacrimal layer using the calculated degree of distortion.

A corneal cover or corneal implant to be placed within or onto the surface of the cornea is made of bony fish scales and a contact lens is made of bony fish scales.

The invention relates to a device for cutting the human cornea using a focused, pulsed femtosecond laser beam comprises scanner components for adjusting the location of the beam focus, a control computer for controlling the scanner components, and a control program for the control computer. The control program contains instructions that are designed to cause a cutting pattern comprising a flap cut (38, 40) to be produced in the cornea when said instructions are executed by the control computer. According to the invention, the cutting pattern further comprises an auxiliary cut (50) that is connected to the flap cut and that leads preferably directly from the flap cut to the cornea surface. The auxiliary cut is advantageously produced before the flap cut and forms a purging channel through which gases that can develop while the flap cut is being cut can escape.

The invention relates to a method of designing a soft contact lens, said lens having a central optic zone and with a peripheral zone around the central optic zone; the method comprising the steps of:(a) defining a back surface of the lens which is a satisfactory fit to the surface of a subject's cornea;(b) defining a front surface of the lens over at least the central optic zone, which surface is selected so as to ameliorate the subject's vision defects;(c) checking that the lens meets a desired range of thickness values at one or more selected parts of the lens and, if not, recalculating the front surface over at least the central optic zone so as to meet said desired thickness value range,wherein the lens is to be made of a substance having a Young's modulus in the range 0.08 to 0.40 MPa, and wherein the junction thickness of the lens is in the range 0.15-0.40 mm.

The invention relates to an eye drop and particularly relates to a preservative-free multi-dose packaged anti-inflammatory eye drop. A formula of the eye drop contains an anti-inflammatory drug, a compound thickening agent, an isoosmotic adjusting agent and a pH adjuster. By utilizing the compound thickening agent, the retention time of the drug on a cornea surface layer can be prolonged, so thatthe dose of the anti-inflammatory drug is reduced, and meanwhile, the anti-inflammatory effect of the eye drop is improved. The invention further provides a preparation method of the eye drop. The anti-inflammatory eye drop does not contain a preservative or a stabilizer, so that the stimulation of the eye drop to eyes is greatly reduced; by carrying out multi-dose packaging through an Aptar device bottle, the invasion of bacteria is avoided, the pollution risk of the drug is reduced, the service life of the multi-dose eye drop is prolonged, the wasting of the drug is avoided, and the productis relatively safe and reliable.

An apparatus and a method for removing epithelium from the cornea include a fluid agent for facilitating de-epithelialization of the cornea. A disc includes a biocompatible material operable for covering a predetermined zone of a cornea. The disc is hydrated by the fluid agent, wherein the hydrated disc is pliable for conforming to a surface of the cornea. An application of the hydrated disc to the cornea substantially constrains the fluid agent to the determined zone and softens a corneal epithelium enabling delamination of the epithelium from an underlying stroma.

A corneal reshaping by means of a soft contact lens to manipulate tear pressure gradient to produce a dimensional change to the surface profile of the cornea of the wearer to provide at least a temporary change in the refractive state of the eye eliminating the need for other refractive corrections. The contact lens has mechanical properties and / or a geometric shape such that when the lens is fitted to the eye the pressure applied to the eye via the lens will vary in a radial direction between at least one zone of higher pressure and at least one zone of lower pressure so that wearing the lens will over time cause a dimensional change to the surface layer of the cornea.

A corneal reshaping by means of a soft contact lens to manipulate tear pressure gradient to produce a dimensional change to the surface profile of the cornea of the wearer to provide at least a temporary change in the refractive state of the eye eliminating the need for other refractive corrections. The contact lens has mechanical properties and / or a geometric shape such that when the lens is fitted to the eye the pressure applied to the eye via the lens will vary in a radial direction between at least one zone of higher pressure and at least one zone of lower pressure so that wearing the lens will over time cause a dimensional change to the surface layer of the cornea.

The invention provides viscoelastic liquid for protecting cornea. The viscoelastic liquid for protecting cornea comprises main components, an osmotic pressure regulator, a pH regulator and water, wherein the main components are selected from single hydroxypropyl methyl cellulose, single chondroitin sulfate, single sodium hyaluronate, composition of hydroxypropyl methyl cellulose and chondroitin sulfate, or the composition of hydroxypropyl methyl cellulose and hyaluronic acid; based on the weight percent of viscoelastic liquid for protecting cornea, the main components comprise 10-30% of hydroxypropyl methyl cellulose, 0.5-10% of chondroitin sulfate, and 0.2-5% of sodium hyaluronate; the pH regulator comprises 1-5% of lactic acid, 0.5-1.5% of sodium hydroxide, 0-3% of tartaric acid, and 0-5% of citric acid; the osmotic pressure of the viscoelastic liquid for protecting cornea is 265-330mOsmol / kg, and pH value is 6.8-7.6. The viscoelastic liquid for protecting cornea is capable of keeping cornea moist, effectively protecting the cornea surface, and effectively decreasing problems related to cornea, such as postoperative dry cornea and surgically induced dry eyes.

Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and / or visible light and / or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW / cm2; thereby obtaining the corneal cross-linking of the solution.

The invention relates to a keratectasia measurement method based on optical CT. The keratectasia measurement method comprises the following steps: 1, acquiring a full-cornea three-dimensional cross section image through optical CT at a long scanning depth; step 2, adopting the shortest path and a dynamic programming optimization algorithm to automatically extract the height information of front and rear surfaces of the full cornea and rebuilding a three-dimensional full-cornea height information graph based on image feature information; step 3, building two indexes representing cornea surface irregularity, namley surface extension rate (as shown in the specification) and cornea surface curvature square (as shown in the specification) based on the height information of the front and rear surfaces of the full cornea. According to the invention, the full-cornea three-dimensional cross section image is acquired through optical CT at the long scanning depth, and the two indexes representing cornea surface irregularity, namely the surface extension rate (as shown in the specification) and the cornea surface curvature square (as shown in the specification) are built.

The invention belongs to the technical field of medicals, and concretely relates to an application of a cornea surface protection agent in general anaesthesia operations. The application of the cornea surface protection agent in general anaesthesia operations is characterized in that the component of the cornea surface protection agent comprises at least one of the following raw materials: cellulose derivatives, hyaluronic acid derivatives, chondroitin sulfate and chitosan derivatives. Compared with traditional application in eye protection pads only applied to the surfaces of eyelids, the cornea surface protection agent can be applied to clinic operations, can be smeared on the surfaces of corneas in the operation process, can keep the wetting of the corneas within a certain time, prevents epithelial injuries of the corneas, and improves the comfort level of postoperative patients.

An apparatus and a method for removing epithelium from the cornea include a fluid agent for facilitating de-epithelialization of the cornea. A disc includes a biocompatible material operable for covering a predetermined zone of a cornea. The disc is hydrated by the fluid agent, wherein the hydrated disc is pliable for conforming to a surface of the cornea. An application of the hydrated disc to the cornea substantially constrains the fluid agent to the determined zone and softens a corneal epithelium enabling delamination of the epithelium from an underlying stroma.

A method of generating three dimensional shapes for a cornea and lens of an eye, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of said eye based on said multiple sections of light. For each one of the obtained multiple sectional images, the following processes are performed:a) automatically identifying arcs, in two-dimensional space, corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the one of the obtained multiple sectional images; andb) determining an intersection of lines ray traced back from the identified arcs in two-dimensional space with a known position of a section of space containing the section of light that generated the one of the obtained multiple sectional images, wherein the determined intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the anterior and posterior cornea surfaces and the anterior and posterior lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.

A time domain-optical coherence tomography (TD-OCT) technology is adopted to carry out high resolution imaging on a human cornea; the thickness of the human cornea can be accurately measured by usinga quick zoom lens; through the moving distance of a reference arm, the optical path difference between the front surface and the rear surface of a cornea can be calculated, thus the refractivity of the cornea can be calculated by ZEMAX optical simulation software; and the method is noncontact and is used to measure the thickness and refractivity of a cornea. The method can measure the thickness and refractivity of a cornea in a human body, the measurement is noncontact, high precision, and nondestructive; moreover, after a corneal surgery, the thickness and refractivity of corneas can be tracked, and at the same time, a preoperative detection device and method are provided for a refractive surgery.

The invention provides an ethyl pyruvate eye drop and a preparation method thereof, and is used for solving the problems of short retention time on ocular surface, low bioavailability, high stimulation and the like of ethyl pyruvate. According to the eye drop, ethyl pyruvate can be effectively supported by using amphipathic chitosan as a micelle vector, the amphipathic chitosan is used as a drug-carrying system, the amphipathic performance of the amphipathic chitosan is utilized, and ethyl pyruvate is effectively entrapped by the lyophobic end of the amphipathic chitosan to improve the penetrability and the adhesion, so that the retention time of the drug on the ocular surface can be effectively prolonged, and the drug is promoted to penetrate into eyes; furthermore, the eye drop has a sustained-release effect, the bioavailability of the drug can be further improved, and the sustained-release duration of 20mu L of the ethyl pyruvate eye drop in one dose can be over 12 hours. Compared with a pure drug of ethyl pyruvate, the ethyl pyruvate eye drop has the advantages that the penetrating capability on cornea can be remarkably improved, the release duration after one dose can be effectively prolonged, and clinical treatment is facilitated.

The invention relates to a stem cell preparation for cornea repair.The stem cell preparation comprises polysaccharide, KGF-2 and mesenchymal stem cells.By combining the polysaccharide, the KGF-2 and the mesenchymal stem cells, the anti-inflammatory effect is achieved, cornea surface cell proliferation can be promoted, cornea epithelial cell proliferation is stimulated, cornea epithelium repair ability and cornea transparency are improved, cornea excessive fibrosis can be prevented, and therefore healing of a damaged cornea is promoted.

A method of eye tracking includes: irradiating a light pattern, output from at least one collimated light source, to a cornea surface; detecting at least a part of the light pattern reflected from the cornea surface, the at least the part of the light pattern being guided by a sensor waveguide; obtaining a mapping image corresponding to the at least the part of the light pattern; and determining a direction of a gaze based on the obtained mapping image. The sensor waveguide used to determine the direction of the gaze is different from a waveguide for displaying output information.

The invention discloses drug sustained release type composite eye drops and a preparation method and application thereof, and belongs to the field of biomedical materials. The composite eye drops comprise a liquid A and a liquid B, wherein the liquid A is a positively charged collagen solution; and the liquid B is a beta-CD-HA solution loaded with a target drug and is negatively charged. The liquid A and the liquid B are electrostatically assembled on the surface of cornea so as to form a composite eye drops coating. The preparation method of the invention is simple and has good repeatability and strong operationality. The prepared drug sustained release type composite eye drops is nontoxic, has functions of drug loading and drug slow-release. By the electrostatic assembly principle, the multilayer composite eye drops coating is formed on the surface of cornea; and drug loading capacity and drug slow-release rate of the composite eye drops coating are regulated. Therefore, retention time of the composite eye drops on the cornea can be prolonged, and administration efficiency is enhanced. The drug sustained release type composite eye drops is a good long-acting administration system for eye disease treatment, is used for eye disease treatment, and has important scientific research significance and good application prospect.

A device for helping to correct imperfections of a cornea includes a molding lens. The molding lens includes an external surface having a concave shape to correspond to the desired shape of the cornea. Heating and cooling elements are located with the molding lens to control the temperature the molding lens, and thus to control the temperature of a substance located on the molding lens.

A method of generating three dimensional shapes for a cornea and lens, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of the eye based on the multiple sections of light. For each obtained multiple sectional image, the following processes are performed:a) automatically identifying arcs corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the obtained multiple sectional images; andb) determining an intersection of lines ray traced back from the identified arcs with a known position of a section of space containing the section of light that generated the obtained multiple sectional images, wherein the intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the cornea surfaces and the lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.