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Application of cornea surface protection agent in general anaesthesia operations

A corneal surface and protective agent technology, applied in the medical field, can solve problems such as corneal epithelial damage, and achieve the effects of preventing corneal epithelial damage and improving comfort.

Inactive Publication Date: 2016-08-03
李志伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the use of the above-mentioned eye protection patch is limited to closing the eyelids to prevent physical damage to the cornea or exposure keratitis caused by the opening of the eyelids during surgery
However, our experiments have shown that eyelid closure under general anesthesia cannot completely avoid the occurrence of keratitis, because tear secretion decreases under general anesthesia, which leads to dryness of the corneal surface and damage to the corneal epithelium

Method used

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  • Application of cornea surface protection agent in general anaesthesia operations
  • Application of cornea surface protection agent in general anaesthesia operations
  • Application of cornea surface protection agent in general anaesthesia operations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] During appendectomy, hydroxypropyl methylcellulose solution was used with a viscosity of 700 mPa·s, a pH of 6.9, and an osmotic pressure of 320 mosmol / kg.

[0035] During the operation, a syringe is used to drop 1ml of the product of the present invention on the surface of the cornea to close the eyelids naturally. The operation time is 1-2 hours, and the patient is under general anesthesia for 2-3 hours. Corneal surface fluorescence staining was performed after the operation to evaluate the protection of the corneal epithelium, and it showed that the corneal epithelium in patients with eyelid application showed diffuse punctate loss (attached figure 1 ), while the corneal epithelium using this product is in good condition without loss (attached figure 2 ). A clinical investigation was conducted on the postoperative effects of 22 patients, including 12 in the application group and 10 in the corneal protective agent group. T test was used to compare the statistical dif...

Embodiment 2

[0037] During appendectomy, sodium hyaluronate solution was used with a viscosity of 700 mPa·s, a pH of 6.9, and an osmotic pressure of 320 mosmol / kg.

[0038]During the operation, a syringe is used to drop 1ml of the product of the present invention on the surface of the cornea to close the eyelids naturally. The operation time is 1-2 hours, and the patient is under general anesthesia for 2-3 hours. Fluorescent staining of the corneal surface was performed after the operation to evaluate the protection of the corneal epithelium. It showed that the corneal epithelium of the patients who used the eyelid application showed diffuse punctate loss, while the corneal epithelium using this product was in good shape and no loss was seen. A clinical investigation was conducted on the postoperative effects of 26 patients, including 13 in the application group and 13 in the corneal protective agent group. T test was used to compare the statistical differences between the two experimental ...

Embodiment 3

[0040] During appendectomy, a chondroitin sulfate solution was used with a viscosity of 700 mPa·s, a pH of 6.9, and an osmotic pressure of 320 mosmol / kg.

[0041] During the operation, a syringe is used to drop 1ml of the product of the present invention on the surface of the cornea to close the eyelids naturally. The operation time is 1-2 hours, and the patient is under general anesthesia for 2-3 hours. Fluorescent staining of the corneal surface was performed after the operation to evaluate the protection of the corneal epithelium. It showed that the corneal epithelium of the patients who used the eyelid application showed diffuse punctate loss, while the corneal epithelium using this product was in good shape and no loss was seen. A clinical investigation was conducted on the postoperative effects of 26 patients, including 13 in the application group and 13 in the corneal protective agent group. T test was used to compare the statistical differences between the two experimen...

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Abstract

The invention belongs to the technical field of medicals, and concretely relates to an application of a cornea surface protection agent in general anaesthesia operations. The application of the cornea surface protection agent in general anaesthesia operations is characterized in that the component of the cornea surface protection agent comprises at least one of the following raw materials: cellulose derivatives, hyaluronic acid derivatives, chondroitin sulfate and chitosan derivatives. Compared with traditional application in eye protection pads only applied to the surfaces of eyelids, the cornea surface protection agent can be applied to clinic operations, can be smeared on the surfaces of corneas in the operation process, can keep the wetting of the corneas within a certain time, prevents epithelial injuries of the corneas, and improves the comfort level of postoperative patients.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to the application of a corneal surface protector in general anesthesia. Background technique [0002] Eyelid closure and corneal moisture during general anesthesia are important conditions to ensure that the cornea avoids physical damage or exposure keratitis during the operation. In order to achieve this purpose in existing operations, eye protection patches need to be pasted on the outside of the eyelids. However, eye protection patches cannot Effectively ensure the moisture of the corneal surface, and the corneal epithelial damage caused by the dryness of the corneal surface cannot be avoided. The corneal protective agent designed in this study is applied to the corneal surface during the operation, which can keep the corneal surface moist within several hours, which can greatly reduce the possibility of corneal epithelial damage and improve the comfort of patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P27/02A61P41/00A61K31/717A61K31/728A61K31/722
CPCA61K31/717A61K9/0048A61K9/08A61K31/722A61K31/728A61K31/737A61K2300/00
Inventor 李志伟牟国营姜丽娟张立伟左立
Owner 李志伟
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