Viscoelastic liquid for protecting cornea

Abstract

The invention provides viscoelastic liquid for protecting cornea. The viscoelastic liquid for protecting cornea comprises main components, an osmotic pressure regulator, a pH regulator and water, wherein the main components are selected from single hydroxypropyl methyl cellulose, single chondroitin sulfate, single sodium hyaluronate, composition of hydroxypropyl methyl cellulose and chondroitin sulfate, or the composition of hydroxypropyl methyl cellulose and hyaluronic acid; based on the weight percent of viscoelastic liquid for protecting cornea, the main components comprise 10-30% of hydroxypropyl methyl cellulose, 0.5-10% of chondroitin sulfate, and 0.2-5% of sodium hyaluronate; the pH regulator comprises 1-5% of lactic acid, 0.5-1.5% of sodium hydroxide, 0-3% of tartaric acid, and 0-5% of citric acid; the osmotic pressure of the viscoelastic liquid for protecting cornea is 265-330mOsmol/kg, and pH value is 6.8-7.6. The viscoelastic liquid for protecting cornea is capable of keeping cornea moist, effectively protecting the cornea surface, and effectively decreasing problems related to cornea, such as postoperative dry cornea and surgically induced dry eyes.

Description

technical field [0001] The invention relates to a corneal protective viscoelastic fluid, which belongs to the technical field of medical products. Background technique [0002] In the vast majority of ophthalmic operations, such as cataract, glaucoma, vitreoretinal surgery, and refractive surgery, it is necessary to expose the cornea, and then make an incision on the cornea or perform related operations. However, after being fixed with a lid speculum, tears cannot pass through the normal closing and opening of the eyelids, which limits the normal diffusion of corneal epithelial microvilli and maintains the moisture of the cornea, thus causing corneal dryness, corneal damage and related postoperative complications. [0003] In addition, it has been reported in the literature that in various ophthalmic operations such as cataract surgery, retinal vitreous body surgery, and corneal LASIK surgery, an incision is made at the cornea, which may cause postoperative dry eye. Such la...

AI Technical Summary

Problems solved by technology

Since BSS is an aqueous solution composed of inorganic salts, it is easy to volatilize, and the time to keep the cornea wet is very short. Therefore, in ophthalmic surgery, especially long-term ophthalmic surgery such as retinal vitreous surgery and corneal laser surgery, a large amount of BSS is required for continuous washing. Then the following problems will be brought: 1) The corneal moistening time maintained by BSS is very short, and it needs to be washed continuously during the operation, the amount of BSS required is very large, and the cost is very high

2) Due to the need for continuous BSS flushing during the operation, the surgeon will suspend the operation and ask the assistant to re-do it to keep the corneal surface moist, which prolongs the operation time and reduces the operation efficiency. It is also a very cumbersome thing to say

3) Since most ophthalmic operations are performed under local anesthesia, the patient can clearly feel the repeated washing during the operation, which greatly reduces the comfort during the operation and the patient's compliance with the doctor after the operation

4) Due to a large amount of washing of BSS, it will destroy the velvet cells on the surface of the cornea, take away a large amount of prot...

Images