30 results about "Epikeratoplasty" patented technology

Optical coherence tomography (OCT) is used to map the surface elevation and thickness of the cornea. The OCT maps are used to plan laser procedures for the treatment of an irregular, opacified or weakened cornea, and in the treatment of refractive errors. In the excimer laser phototherapeutic keratectomy (PTK) procedure, the OCT data is used to plan a map of ablation depth needed to restore a smooth optical surface. In the excimer laser photorefractive keratectomy procedure, OCT mapping of epithelial thickness is used to achieve clean laser epithelial removal. In femtosecond laser anterior keratoplasty procedure, OCT data is used to plan the depth of femtosecond laser dissection to remove an anterior layer of the cornea, leaving a smooth recipient bed of uniform thickness to receive a disk of donated corneal tissue. The linkage of an OCT system to a precise laser surgical system enables the performance of new procedures that are safer, less invasive and produce faster visual recovery than conventional surgical procedures.

A noncontact laser microsurgical apparatus and method for marking a cornea of a patient's or donor's eye in transplanting surgery or keratoplasty, and in incising or excising the corneal tissue in keratotomy, and for tissue welding and for thermokeratoplasty. The noncontact laser microsurgical apparatus comprises a laser source and a projection optical system for converting laser beams emitted from the laser source into coaxially distributed beam spots on the cornea. The apparatus further includes a multiple-facet prismatic axicon lens system movably mounted for varying the distribution of the beam spots on the cornea. In a further embodiment of the method of the present invention, an adjustable mask pattern is inserted in the optical path of the laser source to selectively block certain portions of the laser beams to thereby impinge only selected areas of the cornea.

A method and apparatus related to enhancing corneal accommodation to address the effect of presbyopia. Corneal / scleral topology measurements in accommodating and non-accommodating states are indicative of a presbyopic subject's nominal corneal accommodative power. A desired accommodative power intended to improve on the effect of presbyopia can be determined, suggesting a selective biomechanical intervention in the corneal structure outside of the optical zone to create flexure regions. These flexure regions would allow enhanced corneal accommodation upon presentation of an accommodating stimulus. Intervention could be in the form of, for example, corneal surface ablation, intrastromal ablation, conductive keratoplasty (CK), laser thermal keratoplasty (LTK), and corneal and / or scleral implants. An improved topology measuring apparatus having an improved field of view and other attributes is disclosed.

Improved instrumentation for conductive keratoplasty. The keratoplast probes have longer tips, particularly for use with patients having thick corneas. A kit or group of probes having tips of different lengths can be provided.

The invention provides a tacrolimus ophthalmic preparation and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. According to the present invention, thetacrolimus ophthalmic preparation has a micro-emulsion-like structure, is clarified and transparent, has good patient compliance, is prepared from tacrolimus, oil for injection, a surfactant, a stabilizer, an osmotic pressure regulator, a preservative, a pH value regulator, a tackifier and water for injection, and is used for preventing and treating immunological rejection after corneal transplantation or immunological corneal xerosis and conjunctival xerosis. According to the present invention, with the tacrolimus ophthalmic preparation, the problem of the water insolubilization of tacrolimusis solved, the tacrolimus is firstly prepared into the clarified and transparent eye drops with the micro-emulsion-like structure, the irritation on the eyes by the existing tacrolimus-suspended ophthalmic eye drops can be substantially reduced, and the patient compliance can be improved, such that the tacrolimus ophthalmic preparation of the present invention is suitable for the long-term use byimmunological rejection after corneal transplantation, corneal xerosis and conjunctival xerosis, and other patients with indications.

Improved operational process and procedure for conductive keratoplasty (CK). CK spots are placed at different locations on the cornea depending on the thickness of the cornea. The spots preferably are 80-95% of the thickness of the cornea. Keratoplasty probes with larger tips can be utilized.

The invention belongs to the field of keratoprosthesis stent materials and provides a fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and a preparation method thereof. The skirt stent comprises the following components in percentage by weight: 6wt%-10wt% of fibers, 8wt%-15wt% of biodegradable drug-loading microspheres and 75wt%-86wt% of hydrophilic hydrogel, wherein the fibers are disorderedly distributed in hydrophilic hydrogel. The fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent has special excellent biocompatibility and permeability of hydrogel and very high tensile strength; the inflammations and complications occurring after the corneal transplantation can be relieved by virtue of drugs released by the biodegradable drug-loading microspheres.

The invention relates to a drug used to treat eye immunity disease and restrain increment and new blood vessel, wherein it uses rapamycin as active component at 0.01-2% mass. And the invention can be used to treat Sj gren disease, Mooren ulcer, etc.

The invention discloses an ophthalmic operation ultrasonic scalpel which comprises a handle and a tool bit. The handle is provided with a shell, a power source and an ultrasonic generating device arearranged inside the shell, and the head end of the shell is provided with the output end of the ultrasonic generating device; the tool bit is provided with a tool bit body, the tool bit body is sequentially provided with a connecting part, a limiting installing part and a blade part from bottom to top, the connecting part is used for being detachably connected with the output end of the ultrasonicgenerating device, the limiting installing part is used for installing a limiting mechanism to ensure the cutting depth, and the blade part is used for cutting. The purpose that a blade can instantlycut corneas downwards is achieved, and the scalpel can be used for keratoplasty and corneal limbus dissociation dissection.

The present disclosure generally relates to a technique for centering an application field for an ophthalmic device or a method. More specifically, and without limitation, the disclosure relates to a device and a method for centering an application field relative to the cornea of a human eye responsive to movement of the eye tracked in real-time during the ophthalmic application based on a pupil center. An ophthalmic device or method allows performing one or more procedures with respect to an eye of a patient, such as a surgical, therapeutic and diagnostic procedure, e.g., including and not limited to Laser-Assisted in-situ Keratomileusis (LASIK), Epi-LASIK, PRK, lenticule extraction or keratoplasty.

Improved corrective procedures for conductive keratoplasty are disclosed. Over correction can be relieved by the addition of one or two spots along one of the rings on the cornea.

The invention discloses application of a compound epothilone B to preparing a medicine for healing cornea neurotrauma, and belongs to the field of biological medicines. The pharmacodynamic experiment proves that a rat suffering from cornea neurotrauma is taken as an experimental subject and the area of a cornea nerve is obviously increased by EpoB and is close to the normal level. The compound EpoB stabilizes the tubulin binding, so that the tubulin polymerization is promoted, the depolymerization of a microtube is inhibited, the concentration of the tubulin is increased, the repairing and the reconstruction of the neurotrauma are promoted, and the normal structure and functions of the cornea are maintained. The EpoB has better treatment effects on the function injuries and the cornea nerve lesion caused by refractive surgery, keratoplasty, herpes simplex keratitis, xerophthalmia, diabetes and long-term use of eyedrops, and alleviates the eye symptoms of a patient; and the medicine is low in toxicity and high in stability, and has an important development and application prospect.

The present disclosure generally relates to a technique for centering an application field for an ophthalmic device or a method. More specifically, and without limitation, the disclosure relates to a device and a method for centering an application field relative to the cornea of a human eye responsive to movement of the eye tracked in real-time during the ophthalmic application based on a pupil center. An ophthalmic device or method allows performing one or more procedures with respect to an eye of a patient, such as a surgical, therapeutic and diagnostic procedure, e.g., including and not limited to Laser-Assisted in-situ Keratomileusis (LASIK), Epi-LASIK, PRK, lenticule extraction or keratoplasty.

This disclosure describes a Descemet's membrane endothelial keratoplasty (DMEK) graft prepared using paired incisions; compositions including the incised DMEK graft; an injector including the incised DMEK graft; a viewing chamber including the incised DMEK graft, methods of preparing the incised DMEK graft; and methods of using the DMEK graft, the compositions, the injectors, and the viewing chambers including to facilitate placement of DMEK grafts during cornea transplant surgery.

The invention relates to a device for providing and inserting a transplant or implant into a human or animal body, more particularly for ophthalmological operations, preferably for performing a lamellar keratoplasty, such as a DMEK operation, comprising a cartridge (1) or sleeve, which has a holding region (2) for the transplant or implant and two opposite end openings (3, 4) each fluidically connected to the holding region (2), wherein the first opening (3) has a larger diameter than the second opening (4) and wherein, in order to produce a fluidic connection between the holding region (2) and a syringe (5), both openings (3, 4) can be coupled to the syringe (5) directly or by means of a connecting apparatus. With a view to simply and safely providing and inserting a transplant or implant into the body by simply designed means, the device is designed and further developed in such a way that the cartridge (1) or sleeve is mounted in a holder (6) and that the holder (6) has a pivoting apparatus (7) for pivoting the cartridge (1) or sleeve about a pivot axis (8) into a coupling position for coupling at least one of the two openings (3, 4) to the syringe (5). The invention further relates to a ready-to-use set comprising a device as described above in a sterile packaging.

The invention belongs to the field of keratoprosthesis stent materials and provides a fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and a preparation method thereof. The skirt stent comprises the following components in percentage by weight: 6wt%-10wt% of fibers, 8wt%-15wt% of biodegradable drug-loading microspheres and 75wt%-86wt% of hydrophilic hydrogel, wherein the fibers are disorderedly distributed in hydrophilic hydrogel. The fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent has special excellent biocompatibility and permeability of hydrogel and very high tensile strength; the inflammations and complications occurring after the corneal transplantation can be relieved by virtue of drugs released by the biodegradable drug-loading microspheres.

The invention provides a corneal carrier material and a preparation method thereof and relates to the technical field of tissue engineering. The preparation method of the corneal carrier material, provided by the invention, comprises the steps of subjecting repeated-frozen-thawed human corneal stroma homogenate to decellularizing and then carrying out treatment molding. According to the method, the process is simple and convenient, medical resources are utilized reasonably, and thus, the method is applicable to large-scale production and clinical popularization and application. According to the method, homogeneous corneal stroma homogenate is used as a raw material, and an artificial corneal carrier material is reconstructed on the basis of reserving natural extracellular matrix componentsof cornea, so that the prepared corneal support material has good optical properties, a three-dimensional structure and biocompatibility. Through removing remaining antigenic components from cornea by decellularizing, the probability of an exclusive reaction after corneal transplantation can be lowered, and the success rate of transplantation is increased.

There is disclosed a device for retaining a donor cornea when cutting a donor button. The device comprises a base unit having a hollow cylindrical pedestal projecting therefrom, the pedestal having a central axis and an end remote from the base unit defining an annular basal surface adapted to receive a donor cornea. There may be provided cross-hair means for visually indicating a position of the central axis of the pedestal, and removable retaining means adapted to fit snugly over the pedestal so as to retain the donor cornea securely in position on the end of the pedestal.

Improved corrective procedures for conductive keratoplasty are disclosed. Over correction can be relieved by the addition of one or two spots along one of the rings on the cornea.

An embodiment in accordance with the present invention provides a device and method for performing Descemet's membrane endothelial keratoplasty (DMEK). The device includes a tray for loading a corneal graft, a permeable cap, and a handle for facilitating delivery of the corneal graft into the eye of the recipient. The tray is configured such that the corneal graft is tri-folded on the tray or folded on the donor cornea. The permeable cap allows for hydration and protection of the graft during transit. When it is time to deliver the corneal graft into the eye of the recipient, the tray can be loaded onto the handle after the caps are be removed. A method according to the present invention includes a corneal graft being loaded onto the tray, covered with the permeable cap, and transmitted to the facility doing the corneal transplant.

The invention discloses an artificial cornea. The artificial cornea comprises a support, a metal ring and a cylindrical mirror, the support is fixedly connected with the outer side of the metal ring,the metal ring and the support respectively have a nanocrystallized surface, the cylindrical mirror is embedded in the metal ring, the cylindrical mirror is made from a PMMA material, the cylindricalmirror is a plano-convex cylindrical lens, the reverse surface of the cylindrical mirror is a plane, the front surface is a cambered surface, and the curvature radius of the cambered surface is 6.8-8.8 mm. The optical lens and the support of the artificial cornea are improved, the fixing effect of the titanium alloy ring makes the PMMA mirror cylinder (the cylindrical mirror) modified in a personalized manner according to the thickness of the lesion portion of the lesion cornea of a patient in order to achieve thinning as possible, and only the replacement of the lesion cornea tissue layer ofthe patient and only the implementation of lamellar keratoplasty in the operation process have few damages to the patient and makes the patient quickly recover.

The invention relates to a tearing instrument for the corneal posterior lamella in the ophthalmology. The tearing instrument for the corneal posterior lamella in the ophthalmology comprises tearing forceps and auxiliary hooks; the tearing forceps are provided with a forceps handle, forceps arms, inclined clamping arms and forceps teeth; the forceps handle is connected with the two forceps arms; the inclined clamping arms are connected with the two forceps arms respectively, and the forceps teeth are located at the tail ends of the inclined clamping arms; an include angle is formed between eachinclined clamping arm and the corresponding forceps arm. The direction of the forceps teeth faces the inner sides of the inclined clamping arms. The auxiliary hooks are provided with hook handles, hook arms and hook heads, and the hook arms are connected to the lower ends of the hook handles; the hook arms are downward bent in the reverse direction, and the bent direction of the hook arms is identical to that of the inclined clamping arms. The tearing instrument for the corneal posterior lamella in the ophthalmology has the advantages that through the tearing surgery of the anterior chamber corneal posterior lamella, the case of the turbid residual corneal posterior lamella after deep anterior lamella keratoplasty can be prevented from secondary keratoplasty; meanwhile, decompensation ofthe function of corneal endothelium cannot be caused. The instrument is convenient to operate, the cost can be lowered, and the complication risks are reduced.

The present solution can temporarily impart the handling characteristics of corneal stroma to the otherwise very thin, flimsy, coiling, and fragile Descemet membrane endothelial keratoplasty (DMEK) tissue during its insertion into the anterior chamber and positioning in apposition against the cornea of the recipient eye. The device of the present solution can be configured in a number of ways. In a first configuration, a scaffold can be coupled with the endothelial side of the DMEK graft. In a second configuration, the scaffold can be coupled with the stromal side of the DMEK graft. In a third configuration, one or more scaffolds can be coupled with both the endothelial and stromal side of the DMEK graft.

The invention discloses separation scissors for deep lamellar keratoplasty. The separation scissors comprise a left piece and a right piece which are hinged to each other, the left piece comprises a left scissor head and a left handle, and the right piece comprises a right scissor head and a right handle; the separating scissors further comprise a syringe, and the syringe comprises a cylinder usedfor containing a viscoelastic substance, a push rod used for pushing and injecting the viscoelastic substance and a needle used for transporting the viscoelastic substance; the needle is at least partially fixedly connected to the left or right scissor head. According to the separation scissors, functions of an elastic layer and a rear substrate layer after the viscoelastic substance is separatedand functions of a substrate layer after scissoring can be combined, intraoperative operation is facilitated, and the surgical difficulty is reduced.

It is intended to provide an agent for promoting corneal neuritogenesis containing PACAP, a PACAP derivative or a pharmaceutically acceptable salt thereof, in particular, an agent for promoting corneal neuritogenesis aiming at improving corneal sensitivity, treating dry eye and treating corneal epithelial injury due to an effect of promoting corneal neuritogenesis. This agent for promoting corneal neuritogenesis is useful as a drug for ameliorating reduction in corneal sensitivity following corneal surgeries such as laser keratonomy (LASIK) and corneal grafting or cataract surgery, reduction in corneal sensitivity accompanying corneal neurodegeneration and dry eye symptom and corneal epithelial injury accompanying such reduction in corneal sensitivity. Moreover, it is useful as a drug for ameliorating dry eye symptom, reduction in corneal sensitivity and corneal epithelial injury in patients with dry eye, and a drug for ameliorating corneal epithelial injury and dry eye symptom and reduction in corneal sensitivity accompanying therewith.

The invention relates to a reverse micro-pore forming apparatus for corneas. The reverse micro-pore forming apparatus comprises an upper-end handle, a lower-end handle, an upper-end extension rod, a lower-end extension rod, an adjusting rod, a torsion spring, an extension rod fixing ring, another extension rod fixing ring, a gasket, a depth control shaft and a punch. The reverse micro-pore formingapparatus for the corneas has the advantages that the reverse micro-pore forming apparatus can cling to the human corneas, circumferential resection can be pertinently quickly carried out on turbid portions of posterior lamellar layers of optical zones of the corneas under direct vision on the premise that anterior layers of the corneas are not injured, accordingly, follow-up stripping can be facilitated, and the problem of impaired vision due to donor graft turbidity of lamellar corneal transplantation postoperative optical zones can be solved; implants can be prevented from being involved by lamellar corneal transplantation postoperative primary focus relapse to a certain extent, and the utilization rate of medical resources can be increased.