Fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and preparation method thereof

An artificial cornea and fiber-reinforced technology, applied in medical science, prosthesis, etc., can solve the problems of long biological fixation process of artificial cornea, slow corneal fibers and blood vessels, and complications in the eye, and achieve excellent biocompatibility and safety. Permeability, good biomimeticity, the effect of reducing the chance of complications

Inactive Publication Date: 2015-02-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogel artificial corneal stents are often easily torn due to poor tensile strength during surgical suturing. Even if the artificial cornea is successfully implanted, the interface between the surrounding eye tissue and the implanted artificial corneal skirt The combination of the artificia

Method used

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  • Fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and preparation method thereof
  • Fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and preparation method thereof
  • Fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] In this embodiment, the fiber-reinforced drug-loaded hydrogel artificial corneal skirt support is a sheet-shaped ring, and its structural diagram is shown in figure 1 , its preparation method is as follows:

[0028] (1) Prepare biodegradable drug-loaded microspheres by emulsification and solidification method: add 1g of Span-80, 0.6g of Tween-80, and 46g of liquid paraffin into the container and stir until the mixture is uniform to obtain a mixed solution, and add 10g of the mixed aqueous solution of gelatin and αFGF, in the mixed aqueous solution of gelatin and αFGF, the quality of gelatin is 1.5g, the quality of αFGF is 0.2g, stirs to form emulsion, and in the container, add the glutaraldehyde 2.4mL that concentration is 50wt% , continue to stir for 30 minutes, the emulsion droplets are cross-linked and solidified into balls during the stirring process, then add petroleum ether equal to the volume of the mixed solution and stir for 15 minutes to break the emulsion, ce...

Embodiment 2

[0034] In this embodiment, the structural schematic diagram of the fiber-reinforced drug-loaded hydrogel artificial corneal skirt stent is shown in figure 1 , its preparation method is as follows:

[0035] (1) Prepare biodegradable drug-loaded microspheres by emulsification and solidification method: add 1g of Span-80, 0.6g of Tween-80, and 46g of liquid paraffin into the container and stir until the mixture is uniform to obtain a mixed solution, and add 10g of a mixed aqueous solution of sodium alginate and βFGF. In the mixed aqueous solution of sodium alginate and βFGF, the quality of sodium alginate is 1.6g, and the quality of αFGF is 0.2g. Then stir to form an emulsion, and add a concentration of 50wt to the container. % glutaraldehyde 2.4mL, continue to stir for 30min, the emulsion droplets are cross-linked and solidified into balls during the stirring process, then add petroleum ether equal to the volume of the mixed solution and stir for 15min to break the emulsion, aft...

Embodiment 3

[0040] In this embodiment, the structural schematic diagram of the fiber-reinforced drug-loaded hydrogel artificial corneal skirt stent is shown in figure 1 , its preparation method is as follows:

[0041] (1) Prepare biodegradable drug-loaded microspheres by emulsification and solidification method: add 1g of Span-80, 0.6g of Tween-80, and 46g of liquid paraffin into the container and stir until the mixture is uniform to obtain a mixed solution, and add The mixed aqueous solution 10g of collagen protein and βFGF, in the mixed aqueous solution of described collagen protein and βFGF, the quality of collagen protein is 1.7g, the quality of βFGF is 0.3g, stirs to form emulsion then, and adding concentration is 50wt% pentamethylene in the container Dialdehyde 2.4mL, continue to stir for 30min, the emulsion droplets are cross-linked and solidified into balls during the stirring process, then add petroleum ether equal to the volume of the mixed solution and stir for 15min to break t...

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Abstract

The invention belongs to the field of keratoprosthesis stent materials and provides a fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and a preparation method thereof. The skirt stent comprises the following components in percentage by weight: 6wt%-10wt% of fibers, 8wt%-15wt% of biodegradable drug-loading microspheres and 75wt%-86wt% of hydrophilic hydrogel, wherein the fibers are disorderedly distributed in hydrophilic hydrogel. The fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent has special excellent biocompatibility and permeability of hydrogel and very high tensile strength; the inflammations and complications occurring after the corneal transplantation can be relieved by virtue of drugs released by the biodegradable drug-loading microspheres.

Description

technical field [0001] The invention belongs to the field of artificial corneal stent materials, in particular to a fiber-reinforced drug-loaded hydrogel artificial cornea skirt stent and a preparation method thereof. Background technique [0002] Corneal disease is a blinding eye disease with high morbidity and difficult treatment. Corneal transplantation is currently the most effective and common method to treat this kind of disease. Due to the avascular nature of the cornea, corneal transplantation has become the surgery with the highest success rate of systemic tissue and organ transplantation. At present, most corneas used in corneal transplantation come from donated corneal donors. However, the number of donated corneas is very limited, which is far from meeting the needs of many patients with corneal diseases. Therefore, it is of great significance to research and prepare artificial corneas with properties and functions similar to natural corneas for corneal transplan...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/16A61L27/24A61L27/56A61L27/54
Inventor 张利侯毅李玉宝涂英郭志君
Owner SICHUAN UNIV
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