63 results about "Corneal Transplant" patented technology

A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.

There is disclosed use of certain cyclolignans for prophylaxis or treatment of diabetes mellitus type 2, nephropathy, retinopathy, macular degeneration, retinopathy of prematurity, central retinal vein occlusion, branch retinal vein occlusion, rubeotic glaucoma, thyroid eye disease, corneal graft rejection and corneal chemical burns; and for contraception. Preferred compounds are picropodophyllin, deoxypicropodophyllin and anhydropicropodophyllol. There is also described a method of treatment of an eye disease.

Contour-matching, aspheric lenticules are disclosed for implantation in a subject's cornea to correcting refractive errors. The lenticules include a photoablatable anterior surface and a posterior surface having an aspheric profile that can substantially match the asphericity exhibited by the corneal stromal surface, on which the lenticule is placed. The posterior surface can have a generally concave shape while the anterior surface can have a generally convex shape, though other shapes can also be utilized in some embodiments. In some embodiments, the asphericity of the lenticule's posterior surface can differ from an asphericity exhibited by the corneal stromal surface by less than about 50%, or preferably by less than about 20%.

The invention discloses a ply tissue engineering corneal frame and a manufacturing method and an application thereof, relating to a ply tissue engineering corneal frame of the biomedicine. Compared with the existing materials, the invention provides a ply tissue engineering corneal frame and a manufacturing method and an application thereof, which has abundant resources, high transparency, good biocompatibility, thorough decellularization and strong safety, and the performance approaches to that of a fresh cornea, so that the ply tissue engineering corneal frame can be accepted by majority of patients and applied clinically for a long term. The ply tissue engineering corneal frame is an animal derived decellularized ply corneal stroma sheet and does not contain cellular constituents; collagenous fibers are tidily arranged, and gaps are regular; corneal light transmittance is 80-95%, and tensile strength is 2-5N/mm<2>. The ply tissue engineering corneal frame can be served as the substitute for various donor materials for corneal transplantation and can be used for treating a series of diseases of corneal trauma and chemical burn, corneal tumor and a series of hyperplastic diseases, a series of diseases of corneal neovascularisation and scar, corneal immune diseases, a series of diseases caused by corneal transplantation exclusive reaction and other keratopathy.

A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

The invention discloses a decellularized heterogeneous corneal stromal carrier and its preparation method and application. The carrier is an animal lamellar cornea from which epithelial cells and stromal cells have been removed through hypertonic solution combined with enzyme digestion. The preparation method of the carrier is as follows: firstly, take Fresh animal eyeballs are aseptically operated under an operating microscope, and the lamellar cornea with a thickness of 150 μm to 400 μm is drilled with a graduated trephine drill with a diameter of 5 mm to 12 mm, and then removed under the combined action of hypertonic solution and trypsin/pancreatin substitute The cells are finally dehydrated and dried to obtain the decellularized heterogeneous corneal stroma carrier, which is stored for future use. The decellularized heterogeneous corneal stroma carrier can be used as a corneal transplant donor to directly perform therapeutic corneal transplantation, and can also be used as an artificial biological corneal scaffold to construct a full-layer or lamellar artificial biological cornea. The decellularized heterogeneous corneal stroma carrier prepared by the invention has the following characteristics: the collagen is neatly arranged, similar to normal corneal tissue, and has good transparency after rehydration.

An OCT image of an eye which has been subject to a DSAEK corneal transplant, in which a Descement's membrane in the cornea has been replaced by a graft, is processed to identify the outline of the graft. The process includes the steps of: computationally extracting the boundary of the cornea including the graft; computationally detecting the corners of the graft; computationally extracting points on the boundary between the graft and the original cornea; and computationally fitting the points on the boundary between the graft and the original cornea smoothly into a curve. The outline of the graft is then displayed. A graft profile may be generated, indicating the thickness of the graft at each point along its length.

The invention discloses an operation mechanism for an ophthalmic corneal transplantation surgical robot. The operation mechanism includes two bases arranged beside an operating table, two robotic armsrespectively fixed on vertical lifting platforms of the bases, at least two instrument-holding arms to simulate the hands of a surgeon and a mirror-holding arm to place imaging equipment; each instrument-holding arm includes a preoperative positioning mechanism and an intraoperative instrument-manipulating mechanism; the preoperative positioning mechanism is used for positioning the intraoperative instrument-manipulating mechanism; the intraoperative instrument-manipulating mechanism includes a position adjusting mechanism and a pose adjusting mechanism; the position adjusting mechanism can realize the position adjusting of the pose adjusting mechanism in space; and the motion and force transmission of the pose adjusting mechanism can be achieved through a rope-pulley mechanism so as to control tools to perform operations. Through the operation mechanism, the movement track of operation tools at any position and pose in a working space can be realized, and corneal drilling and suturing during corneal transplantation can be accomplished; and the operation mechanism is good in flexibility, high in precision, high in motion stiffness and large in motion space range.

The present invention relates to a femtosecond laser ophthalmological apparatus and method that creates a flap on the cornea for LASIK refractive surgery or for other applications that require removal of corneal and lens tissue at specific locations, such as in corneal transplants, stromal tunnels, corneal lenticular extraction and cataract surgery. The femtosecond laser is transferred from the main cabinet to a hand piece module via a rotating mirror set module. In the hand piece, the femtosecond laser beam is scanned and guided to the patient's eye. The ablation pattern is based on dividing the area of the ablation area into a matrix grid made up of cells. Predetermined ablation pattern is completed in an individual cell before moving on to the next cell until ablation is complete in the entire matrix grid mapped on the ablation area.

An ophthalmic irrigating solution containing hyaluronidase and an antioxidant is provided. The solution prevents a post-operative intraocular pressure rise when used during an ophthalmic surgical procedure, and also protects corneal endothelial cells. A method for preventing post-operative intraocular pressure increases in an eye during ophthalmic surgery involves irrigating an anterior chamber of the eye with an ophthalmic-solution containing hyaluronidase and an antioxidant. Kits containing hyaluronidase and base medium solutions are also provided. The kits are designed such that the hyaluronidase and base medium solution are combined and administered together to an eye of a patient during or following an ophthalmic surgical procedure, such as cataract surgery, intraocular lens surgery, corneal transplant surgery, or glaucoma surgery. Administration of the components of the kit prevents an increase in post-operative intraocular pressure and also protects corneal endothelial cells.

The invention relates to application of piperlongumine in preparation of a medicine for preventing and treating immunological rejection in corneal transplantation. Researches prove that the natural compound piperlongumine can effectively relieve immunological rejection in corneal transplantation and prolong the survival time of the corneal graft in a transplant rejection animal model, and possible mechanisms comprise inhibition of generation of immune cells and local infiltration and reduction of secretion of related inflammatory cytokines. The invention proves the effectiveness of the natural compound piperlongumine in treating the immunological rejection after the corneal transplantation, and shows that the piperlongumine has great development potential and research value when being used as a new anti-rejection medicine after the corneal transplantation.

A transplant tissue storage, transport, and/or placement apparatus, including at least some of a transplant device extending from a distal portion to a proximal portion; a tissue support element formed in the distal portion, the tissue support element having an upper surface having a tissue support element configured to support a central portion of transplant tissue, and a transplant tissue securing mechanism with opposing first securing pad and the second securing pad configured for clasping opposing peripheral portions of transplant tissue in a draped configuration; and a lockable arrangement formed in the proximal portion, the lockable arrangement configured to release a secured transplant tissue from the mounting surface, upon actuation.

The invention discloses a membrane non-uniformity biological material transparency screening method. The membrane non-uniformity biological material transparency screening method comprises the steps of biological material saccharose dehydration, OCT embedding, layer-by-layer frozen section, transparency measurement by using a spectrophotometer and the like. The invention also provides a high-transparency decellularized dermal matrix obtained by using the method. Through the invention, the decellularized dermal matrix with optimal transparency can be screened effectively, the decellularized dermal matrix can be used for lamellar keratoplasty, the matrix can be used for replacing an existing lamellar cornea matrix in the operation by an operating doctor, and the contradiction of donor corneashortage at present can be further solved effectively while the cornea diseases of patients are cured.

The invention relates to the technical field of medical biomaterials, in particular to a culture medium, a corneal stromal slice prepared by the culture medium and a preparation method. The medium provided by the invention is a Dulbecco's modified eagle medium/F12 (DMEM/F12) medium containing a porcine corneal extract, Y-27632, insulin-transferrin-selenium (ITS), fibroblast growth factors (FGF), ascorbic acid and fetal bovine serum. According to the medium, by selecting suitable active components and proportion, a corneal stromal cell and corneal stromal slice prepared by employing the mediumhave the functions of maintaining the corneal stromal cell phenotype, promoting proliferation, improving vitality, resisting fibrosis and resisting apoptosis, and the like in comparison with a cornealstromal cell and corneal stromal slice prepared by a traditional medium. The corneal stromal slice disclosed by the invention is prepared by taking a corneal lens as a raw material and culturing thecorneal lens by employing the medium; and compared with animal-derived corneal repair material, the corneal lens has good biocompatibility and no antigenicity, can be used as substitutes of various donor materials for corneal transplantation, and can be accepted by the majority of patients and is clinically applied for long.

The invention provides an AR operation navigation system and method for lamellar keratoplasty. The AR operation navigation system for the lamellar keratoplasty includes a camera unit, a processing unit and an AR unit connected in turn; the camera unit is used for obtaining a video image in the process of the lamellar keratoplasty; the processing unit is used for segmenting a corneal contour in each frame of the video image to obtain a multi-frame corneal contour image, the multi-frame corneal contour image is divided into multiple keyframe corneal contour images and multiple occlusion frame corneal contour images, when current frame corneal contour images are the occlusion frame corneal contour images, occluded motion information of the current frame corneal contour images is restored, thekeyframe corneal contour images are deformed to reconstruct the current frame corneal contour images, then the AR unit is controlled to overlay a marker in the current frame corneal contour images tomark the contour of cornea and a plurality of positions of corneal suture, thus a doctor is guided to find the positions of the corneal suture timely and accurately, and the success rate of an operation is increased.