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Membrane non-uniformity biological material transparency screening method and decellularized dermal matrix

A technology of acellular dermis and biomaterials, which is applied in the field of membrane-like heterogeneous biomaterial transparency screening methods and high-transparency acellular dermal matrix, can solve the problems of no screening method, inhomogeneous transparency, and homogeneous acellular dermal matrix. The problem of poor quality and other problems, to achieve the effect of fewer instruments and experimental materials, and easy operation

Active Publication Date: 2019-02-12
PEKING UNIV THIRD HOSPITAL
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Problems solved by technology

According to the technical solution of the present invention, the current problems of poor homogeneity between different layers of acellular dermal matrix, uneven transparency and no effective screening method can be solved.

Method used

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  • Membrane non-uniformity biological material transparency screening method and decellularized dermal matrix
  • Membrane non-uniformity biological material transparency screening method and decellularized dermal matrix
  • Membrane non-uniformity biological material transparency screening method and decellularized dermal matrix

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Embodiment Construction

[0037] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention. The present invention will be further described in detail below through specific implementation examples in conjunction with the accompanying drawings.

[0038] Such as figure 1 As shown, a method for screening the transparency of membrane-like heterogeneous biological materials includes the following steps:

[0039] 1) Extracting sucrose dehydration: use trephine to drill a circular membrane-like non-uniform biological material with a diameter of 6mm, and apply 20% sucrose at 4°C for 24 hours for dehydration. The suc...

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Abstract

The invention discloses a membrane non-uniformity biological material transparency screening method. The membrane non-uniformity biological material transparency screening method comprises the steps of biological material saccharose dehydration, OCT embedding, layer-by-layer frozen section, transparency measurement by using a spectrophotometer and the like. The invention also provides a high-transparency decellularized dermal matrix obtained by using the method. Through the invention, the decellularized dermal matrix with optimal transparency can be screened effectively, the decellularized dermal matrix can be used for lamellar keratoplasty, the matrix can be used for replacing an existing lamellar cornea matrix in the operation by an operating doctor, and the contradiction of donor corneashortage at present can be further solved effectively while the cornea diseases of patients are cured.

Description

Technical field [0001] The invention relates to the field of medical biomaterials, in particular to a method for screening the transparency of membrane-like non-uniform biomaterials and a highly transparent acellular dermal matrix. Background technique [0002] The human cornea is a transparent membrane-like structure on the front of the human eye, which is an important component of the refractive system of the eye, and its function mainly depends on its optical characteristics. At present, changes in the optical properties of the cornea caused by various corneal diseases and injuries have become one of the main causes of human blindness, ranking second only after cataracts. For irreversible corneal blindness, the most effective and recognized treatment method is allogeneic corneal transplantation. However, there is a serious shortage of corneal donors every year in my country. The lack of corneal materials has become the most important factor restricting the promotion of cornea...

Claims

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Application Information

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IPC IPC(8): G01N21/31A61L27/36A61L27/50
CPCA61L27/3633A61L27/50A61L2430/16G01N21/31
Inventor 李学民王岳鑫邱伟强刘子源
Owner PEKING UNIV THIRD HOSPITAL
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