60 results about "Matrix cell" patented technology

Bacteria which co-express protease inhibitors and protease sensitive therapeutic agents, which are surface displayed, secreted and / or released and result in their localized production and maintenance within a target tissue and inactivation outside of the target tissue, thereby increasing therapeutic activity and reducing the systemic toxicity. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. Protease sensitivity may be further accomplished by engineering protease degradation sites within the therapeutic agents, further enhancing the inactivation outside of the target tissue while retaining activity within the target tissue through co-expression of a protease inhibitor. Novel chimeric proteins secreted by bacteria, including chimeric toxins targeted to neoplastic cells, tumor matrix cells and cells of the immune system, and combination therapies of these protease inhibitor:chimeric toxin-expressing bacteria together with small-molecule and biologic agents are also described. Non-conjugative bacteria limiting exchange of genetic material, and antibody resistant bacteria are also provided.

Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body. The cell delivery matrix may be biocompatible and semi-permeable. The cell delivery matrix used in the methods of the invention may be comprised of any degradable, bioabsorbable or non-degradable, biocompatible polymer. Regenerative therapies comprising implanting in the subject cell delivery matrices localizing adipose derived endothelial cells are described. The cell delivery matrices maintain the adipose derived endothelial cells at the target for a therapeutically effective amount of time. The adipose derived endothelial cells can be allogenic or syngenic to the subject. The endothelial cells may be delivered alone or in combination with other therapeutic agents.

The invention aims at providing a novel full-thickness biological cornea used for transplantation. The full-thickness biological cornea takes an animal cornea acellular matrix as a carrier, and the acellular matrix comprises animal cornea matrix cells, epithelial cells and endothelial cells which are cultured and augmented in vitro. The cornea is characterized in that the xenogenic corneal acellular matrix prepared by a biochemical method can be used as a good carrier for in vitro constructing the biological cornea in the aspects of shape, structure and biological compatibility, the matrix cells, epithelial cells and endothelial cells of the cornea are planted respectively, and dynamically cultured in the simulated in vivo environment of a biological reactor, so that the full-thickness biological cornea with nearly normal tissue structure and characteristics can be constructed in vitro, and the biological cornea can be used to simulate the physiological cornea for fundamental research on physiology, pathology and pharmacology; moreover, the biological cornea can also be directly used as the donator for corneal transplantation.

The invention provides a method for reshaping and beautifying by using tissue engineering fat regeneration technology, which is applicable to plastic surgery and reshaping and beautifying and belongs to the field of tissue engineering. The method comprises the following technical routes: directly extracting mesenchyme matrix cells with multiple differentiation capabilities from fatty tissues of a patient, culturing and propagating the mesenchyme matrix cells in vitro, wrapping a specific amount of cells and other necessary components in a hydrogel stent material, and implanting the hydrogel stent material into the corresponding part in the body of the patient. The cells are grown into fatty tissues along with degradation and absorption of the stent material so as to perform regenerative repair on the soft tissue defect of the patient. The method has the advantages that the cells of the patient do not bring immunological rejection to the patient, and the regenerative repair effect is safe, natural and durable because the used hydrogel stent material is finally degraded and absorbed in the body of the patient.

Methods and systems for coding SAW OFC devices to mitigate code collisions in a wireless multi-tag system. Each device producing plural stepped frequencies as an OFC signal with a chip offset delay to increase code diversity. A method for assigning a different OCF to each device includes using a matrix based on the number of OFCs needed and the number chips per code, populating each matrix cell with OFC chip, and assigning the codes from the matrix to the devices. The asynchronous passive multi-tag system includes plural surface acoustic wave devices each producing a different OFC signal having the same number of chips and including a chip offset time delay, an algorithm for assigning OFCs to each device, and a transceiver to transmit an interrogation signal and receive OFC signals in response with minimal code collisions during transmission.

The invention relates to methods for differentiating umbilical cord matrix cells into hepatocyte-like cells and compositions and methods for using such hepatocyte-like cells.

The invention relates to the isolation and use of stem cells from amniote species (potentially any animal with an umbilical cord, including humans). More particularly the invention relates to obtaining stem cells that are at least multipotent and may be totipotent or nearly totipotent and are envisaged to have a variety of end uses. The cells of the present invention are immunosuppressive and may be used to inhibit the immune response in a subject.

Methods and systems for coding SAW OFC devices to mitigate code collisions in a wireless multi-tag system. Each device producing plural stepped frequencies as an OFC signal with a chip offset delay to increase code diversity. A method for assigning a different OCF to each device includes using a matrix based on the number of OFCs needed and the number chips per code, populating each matrix cell with OFC chip, and assigning the codes from the matrix to the devices. The asynchronous passive multi-tag system includes plural surface acoustic wave devices each producing a different OFC signal having the same number of chips and including a chip offset time delay, an algorithm for assigning OFCs to each device, and a transceiver to transmit an interrogation signal and receive OFC signals in response with minimal code collisions during transmission.

The present invention relates to in vitro three-dimensional organotypic cell co-culture. Cultures of the invention comprise tumour cells three-dimensionally disposed within a matrix of matrix cells which are distinct from the tumour cells, wherein the co-culture does not comprise a basement membrane. The cultures are useful for the study of cancers, for testing anti-tumour agent efficacy, and for high-throughput screening of candidate drugs.

Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix cell cultures of the invention have a variety of totipotent, pluripotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any amniotic animal, including agricultural and laboratory animals and humans. The invention relates to isolating the stem cells, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment.

The invention relates to the technical field of recognition of objects in audiovisual documents. The method uses multimodal data that is collected and stored in a similarity matrix. A level of similarity is determined for each matrix cell. Then a clustering algorithm is applied to cluster the information comprised in the similarity matrix. Clusters are identified, each identified cell cluster identifying an object in the audiovisual document.

This invention relates to a method for analysing pressure-signals derivable from pressure measurements on or in a body of a human being or animal, comprising the steps of identifying during given time sequences in a series of time sequences the single pressure waves, including related parameters [pressure amplitude ΔP, latency (ΔT), rise time coefficient (ΔP / ΔT)], determining numbers of single pressure waves with pre-selected combinations of two or more of said single pressure wave parameters during said time sequence. For the time sequences is further determined the balanced positions of single wave parameters. Two-dimensional values of balanced position may be presented as a one dimensional value after weighting of the matrix cells. The signal processing method may be used for more optimal detection of single pressure waves by means of non-invasive sensor devices.

The invention relates to a method for differentiating an induced pluripotent stem cell into a hepatocyte through directed induction, and the hepatocyte thereof. The method is characterized in that different media are added in different stages of directed induction differentiation to carry out directed induction differentiation of the induced pluripotent stem cell. The change of the form of the cell can be momentarily observed in the operating process to ensure normal implementation of induction, so a required liver precursor cell can be fast and efficiently obtained through induction. The method for differentiating the induced pluripotent stem cell into the hepatocyte through directed induction adopts a culture system of feeder-free cells, the hepatocyte can be obtained only through adding an induction medium in a corresponding stage, and a detection result shows that the purity is high. The method for differentiating the induced pluripotent stem cell into the hepatocyte through directed induction has the advantages of short induction period, high efficiency, stable performances and mature functions of the obtained hepatocyte, and no matrix cell pollution.

The invention discloses a chronic glaucoma animal model establishing method. The method comprises the following steps: (1) collecting conjunctiva tissues of GFP-SD rats, sterilizing, digesting, separating a conjunctiva epithelial layer, and obtaining a conjunctiva matrix tissue block; (2) digesting the conjunctiva matrix tissue block in pancreatin, terminating the digestion by using a cell culturesolution, blowing and beating to form a single-cell suspension, filtering by virtue of a cell sieve, centrifuging, and removing supernatant, thus obtaining conjunctiva matrix cell precipitates; (3) adding an appropriate amount of cell culture solution, blowing and beating to form single cells, counting, performing the in-vitro culture, and obtaining a remarkable amount of conjunctiva matrix cells; (4) digesting the conjunctiva matrix cells by using pancreatin, processing by utilizing the method of the step (2), obtaining the conjunctiva matrix cell precipitate, adding an appropriate amount ofcell culture solution, and obtaining cell suspension; and (5) injecting 10 micro liter of cell suspension by utilizing a micro injector into the anterior chamber of the right eye of a rat, and sufficiently and uniformly mixing. A glaucoma animal model obtained by using the method has the advantages of long-term stability, simplicity, ease, good repetition, and low cost.

The invention discloses a high-temperature bionic self-lubricating hot work die material which comprises a matrix skeleton and a sold lubricating material; the matrix skeleton is a metal skeleton which is prepared by alloy powder through a rapid formation technology and has a microporous structure with regular distribution; micropores in the metal skeleton are connected with and penetrated through one another; and the sold lubricating material is stored in the micropores in the metal skeleton to precipitate out during die work to achieve the lubrication antifriction effect. By adopting the high-temperature bionic self-lubricating hot work die material provided by the invention, the problems that the infiltration performance between a lubricant and a matrix is poor, the interface bonding strength between the lubricant and the matrix is low, a solid lubricant is insufficient in burning loss in the sintering process, and shapes and distribution of matrix cell holes are difficultly controlled to cause defects of connection performance of the micropores and randomness of material strength are solved.

An electronic memory circuit comprises a matrix of EEPROM memory cells. Each memory cell includes a MOS floating gate transistor and a selection transistor. The matrix includes a plurality of rows and columns, with each row being provided with a word line and each column comprising a bit line organized in line groups so as to group the matrix cells in bytes, each of which has an associated control gate line. A pair of cells have a common source region, and each cell symmetrically provided with respect to this common source region has a common control gate region.

An electronic memory circuit comprises a matrix of EEPROM memory cells. Each memory cell includes a MOS floating gate transistor and a selection transistor. The matrix includes a plurality of rows and columns, with each row being provided with a word line and each column comprising a bit line organized in line groups so as to group the matrix cells in bytes, each of which has an associated control gate line. A pair of cells have a common source region, and each cell symmetrically provided with respect to this common source region has a common control gate region.

The invention discloses a micro-fluidic chip for cell migration and a preparation method of the micro-fluidic chip. The micro-fluidic chip is provided with a flow layer, a control layer, a film layerand a glass layer from top to bottom; the flow layer consists of a pyramid-shaped network structure, a cell culture zone, a cell migration zone, a main pipeline and a liquid inlet micro pipeline; andthe control layer consists of a plurality of micro valves. The invention also provides a preparation method of the micro-fluidic chip. A biochemical factor / medicine concentration gradient is formed inthe main pipeline and the cell migration area, the effect of the biochemical factors / medicine of different concentrations for the cell migration can be researched in a same chip, and the conventionalmode for researching the effect of the single-concentration biochemical factor / medicine for the cell migration is broken through. The invention can also realize the environment construction of an extracellular matrix and co-culture of target cells and matrix cells, and the micro-fluidic chip is used for researching the haptotaxis of the extracellular matrix and the matrix cell for the target cell. Therefore, the cell migration can be researched by combining the biochemical factor / medicine concentration gradient and cell micro environment simulation.

The invention relates to the technical field of biological medicine, in particular to a preparation for promoting skin wound heeling, a preparation method of the preparation and application of the preparation. The preparation for promoting the wound heeling comprises the following raw materials including hyaluronic acid, autologous fibroblasts and matrix cell derived factors; when the preparation is used as wound heeling medicine, the fast wound heeling effect can be achieved; an obvious curative effect is particularly achieved on the wound surface of a patient with large-area burns and scalds; the pain of the patient can be greatly reduced; the living quality of the patient is obviously improved; the concentration of each raw material ingredient in the preparation is lower, so that the cost is lower.

The invention aims at providing a medicine for treating keratoconus, which takes an Nrf2-ARE signal path as a target. The medicine can activate the signal path or improve the expression of downstream antioxidant genes NQO-1 and SOD2, so as to reduce the expression of matrix degrading enzymes; therefore, the medicine is suitable for the treatment of keratoconus. The medicine disclosed by the invention, which is used for treating the keratoconus by virtue of a methylation inhibitor 5-aza, can improve the expression of antioxidant genes of keratoconus matrix cells and can reduce the content of the matrix degrading enzymes as well.

A method for analyzing a multidimensional data set includes generating a multidimensional mass spectrometry data set from a sample; and generating an matrix representing the multidimensional mass spectrometry data set such that a first dimension and a second dimension of the multidimensional mass spectrometry data set correspond to a matrix cell location, and an ion intensity corresponds to a matrix cell value; and determining a class of the matrix from a plurality of matrix classes using a trained neural network matrix classifier.

The invention relates to the technical field of power batteries, and discloses an intelligent scheduling and tracing system and method for a power battery formation process, so as to realize scheduling intelligence and product tracing convenience in a production process. The system comprises a code printing and tray filling machine for printing battery codes; a battery container tray which is provided with a readable and writable RFID chip and matrix cells; a central server; a reader-writer for reading RFID chip information of the battery container tray which is arranged in each clamping groove structure of the formation cabinet; after the battery container tray is placed in the formation cabinet, the edge computing server controls the formation cabinet to perform a normal charging and discharging process according to the initialized production process, and records the charging and discharging data of each battery in system traceability associated information; the associated information further comprises RFID information of each battery code and the corresponding tray, coding information of corresponding cells in the tray and point location information of the formation cabinet; the system further comprises a sorting device for sorting the batteries according to the capacity sections based on the RFID chip information.

The invention relates to an LED display microarray and a preparation method thereof and belongs to the technical field of semiconductor illumination. The LED display microarray comprises a substrate epitaxial wafer, a semiconductor matrix isolation region, an insertion layer, an electronic conducting layer, a light-emitting layer, a hole conducting layer, an electronic conducting electrode, a hole conducting electrode, an isolation protecting layer, anode lines and cathode lines. An epitaxial layer is subjected to dry etching so that the electronic conducting layer and a semiconductor matrix cell array are obtained; the electronic conducting layer to the insertion layer is subjected to dry etching so that isolation of each two adjacent cells is achieved, and the semiconductor matrix isolation region is obtained; the electronic conducting electrode is formed to lead the cathode lines out; the isolation protecting layer is deposited; the hole conducting electrode is formed to lead the anode lines out; and the spatially intersectional regions of the anode lines and the cathode lines are display pixels. By the LED display microarray and the preparation method, the insertion layer is grown epitaxially to achieve isolation, the problem of electricity leakage caused by process difficulty in achievement of deep isolation trenches by a dry etching method is reduced, the depth of isolation trenches is decreased, and cost is lowered.

A cross-bar matrix includes a plurality of matrix cells arranged in rows and columns wherein each row of cells is associated with a signal input and each column of cells is associated with a common signal output. An enable input controls whether at least a portion of the cells couple a signal on the associated common signal input to a signal output associated with a cell or couple an LCD signal to a signal output and exclude control of the at least portion of said plurality of cells by the control input.

A method and control device is used for testing electronic memory devices. The method comprises loading test data and / or instructions into a control logic circuit portion associated with a matrix array of memory cells and integrated storage circuitry. According to the invention, a test operation control device is used temporarily instead of the control logic, the test operation control device being external of and connected detachably to the memory device. Advantageously, the test operation control device is a matrix cell array external of the memory.

This invention relates to a method for analysing pressure-signals derivable from pressure measurements on or in a body of a human being or animal, comprising the steps of identifying during given time sequences in a series of time sequences the single pressure waves, including related parameters [pressure amplitude ΔP latency (ΔT), rise time coefficient (ΔP / ΔT)], determining numbers of single pressure waves with pre-selected combinations of two or more of said single pressure wave parameters during said time sequence. For the time sequences is further determined the balanced positions of single wave parameters. Two-dimensional values of balanced position may be presented as a one dimensional value after weighting of the matrix cells. The signal processing method may be used for more optimal detection of single pressure waves by means of non-invasive sensor devices.