Application of piperlongumine in preparation of medicine for preventing and treating immunological rejection in corneal transplantation

A technology of longinamide and transplantation immunity, applied in the field of medicine, can solve problems such as immune rejection of corneal transplantation that have not yet been found, and achieve the effects of relieving immune rejection, prolonging survival time, and inhibiting local infiltration.

Inactive Publication Date: 2021-08-13
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there are no relevant reports on the use of perylene amide in the treatment of corneal transplantation immune rejection.

Method used

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  • Application of piperlongumine in preparation of medicine for preventing and treating immunological rejection in corneal transplantation
  • Application of piperlongumine in preparation of medicine for preventing and treating immunological rejection in corneal transplantation
  • Application of piperlongumine in preparation of medicine for preventing and treating immunological rejection in corneal transplantation

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Experimental program
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Embodiment 1

[0030] 1. Analysis of the effect of perylene amide on allogeneic immune rejection of corneal transplantation

[0031] 1) Establishment of mouse corneal transplantation model:

[0032] Male C57BL / 6 mice aged 6-8 weeks were used as corneal donors, and male BALB / c mice aged 4-6 weeks were randomly selected as recipients for penetrating keratoplasty (PKP). The specific method is as follows: intraperitoneal injection of 4% chloral hydrate anesthesia (10mL / kg), obucaine hydrochloride eye drops for ocular surface anesthesia 10 minutes before the operation, compound tropicamide eye drops fully dilated mydriasis, and Central full-thickness cornea of ​​C57BL / 6 mice was harvested by trephine drilling in ophthalmology, with a diameter of 2 mm and placed on the recipient corneal bed with a diameter of 1.5 mm. Eight stitches were sutured intermittently with 11-0 sutures, and viscoelastic was injected after the operation. agent to restore the anterior chamber. After the operation, tobramyc...

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Abstract

The invention relates to application of piperlongumine in preparation of a medicine for preventing and treating immunological rejection in corneal transplantation. Researches prove that the natural compound piperlongumine can effectively relieve immunological rejection in corneal transplantation and prolong the survival time of the corneal graft in a transplant rejection animal model, and possible mechanisms comprise inhibition of generation of immune cells and local infiltration and reduction of secretion of related inflammatory cytokines. The invention proves the effectiveness of the natural compound piperlongumine in treating the immunological rejection after the corneal transplantation, and shows that the piperlongumine has great development potential and research value when being used as a new anti-rejection medicine after the corneal transplantation.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of perylene amide in the preparation of medicines for preventing and treating immune rejection of corneal transplantation. Background technique [0002] Corneal transplantation is a common way to treat end-stage corneal diseases. Although the success rate is higher than that of other organ transplants, postoperative rejection is still the main reason for surgical failure. At present, the drugs used clinically to treat immune rejection after keratoplasty mainly include conventional immune preparations such as glucocorticoids, cyclosporine, and tacrolimus. [0003] Glucocorticoids: Glucocorticoids are currently the most widely used anti-rejection drugs, but they have poor curative effect on high-risk corneal transplant patients, and their long-term use has obvious side effects. [0004] Cyclosporine: Systemic administration of cyclosporine can effectively prevent postoperat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4412A61K31/436A61K38/13A61K45/06A61K36/67A61P37/06A61P27/02
CPCA61K31/4412A61K31/436A61K38/13A61K45/06A61K36/67A61P37/06A61P27/02
Inventor 范祥雨张婧徐建江
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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