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Application of dragon blood and dragon-blood extract

A technology of dragon's blood and its extract, which is applied in the field of pharmaceutical use of dragon's blood and its extract, can solve the problem that the tolerable dose is not enough to eradicate tumors, achieve good radiation protection, relieve fatigue, reduce Mortality Effect

Active Publication Date: 2009-10-21
北京理工亘舒科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But often the maximum tolerated dose is not enough to eradicate the tumor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of the total phenols of embodiment 1 dragon's blood

[0031] Get dragon's blood raw material drug (Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd. production, approval number: Z53021662) 1Kg, add 95% (v / v) ethanol to all dissolving, add distilled water until the alcohol content is 40% ( v / v), filter, get the supernatant, the precipitation part repeats the above-mentioned operation 3 times, and the supernatant merges; ) ethanol for elution, discard the eluent, elute with 80% (v / v) ethanol of 8 times the column volume, and recycle the solvent from the eluent to dryness to obtain 0.58Kg of total phenols of dragon's blood.

Embodiment 2

[0032] The preparation of embodiment 2 dragon's blood jerky total flavonoids

[0033] Take dracaena raw material drug (produced by Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd., approval number: Z53021662) 1Kg, add 8 times the amount of ethyl acetate to reflux and extract twice, each time for 1 hour, filter, and combine twice Filtrate, reclaim ethyl acetate and concentrate to dryness; The ethyl acetate extract is pulverized into coarse powder, stirs 30 minutes with the 0.35% (v / v) NaOH solution of 30 times of extract amount to dissolve, filter; Filtrate with 10% ( v / v) Adjust the pH to 1-2 with HCl, let it stand for 12 hours, pour out the supernatant, and discard; the precipitate is centrifuged and filtered, and the precipitate is collected, washed with deionized water until the pH test paper detects it as neutral, below 60°C Vacuum-dried, pulverized, and passed through an 80-mesh sieve to obtain 0.50 kg of total flavonoids of dragon's blood.

Embodiment 3

[0034] Embodiment 3 Anti-radiation effect of dragon's blood drug prophylaxis

[0035] experimental method

[0036] Thirty-six Wistar rats (half male and half female) were randomly divided into two groups, namely the model control group (no radiation administration) and the administration group (radiation+administration). Before radiation, the administration group was given dracaena raw material drug (produced by Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd., approval number: Z53021662) once a day by intragastric administration at a dose of 2 g / kg, and the model control group was given etc. The volume of the solvent control was administered continuously for 5 days. Carry out heavy ion radiation 2 hours after administration on the 6th day: the energy is 80MeV / u 12 C 6+ The ions were generated at the Lanzhou Heavy Ion Accelerator (HIRFL) at the Institute of Modern Physics, Chinese Academy of Sciences. After anesthetizing the rats, 12 C 6+ Ions were given a one-time lo...

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Abstract

The invention relates to application of dragon blood and dragon blood extract, which belongs to the field of Chinese medicaments. In particular, the invention relates to the application of dragon blood raw medicinal materials, dragon blood total phenols and dragon blood total flavonoids in preparing medicaments for preventing or treating radiation damage. In order to achieve the application of the invention, the application of the dragon blood or the dragon blood extract via or not via gastrointestinal tract includes but is not limited to oral, subcutaneous, intramuscular, intravenous, transdermal, nasal and rectal administration. Pharmaceutical compositions prepared from the dragon blood or the dragon blood extract and medically acceptable pharmaceutical excipient include but are not limited to various types of tablets, capsules, dropping pills, soft capsules, oral solution, pills, powder, granules, lozenges, decoction paste, syrup, liquid extract agent, extract agents, injections, as well as other clinically appropriate dosage forms. A preparation contains necessary additives, and the additives include but are not limited to fillers, wetting agents, adhesives, disintegrants, lubricants or pH regulators.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and mainly relates to a medicinal use of dragon's blood and its extract. Specifically, the present invention relates to an application of dragon's blood and its extract in the preparation of medicines for preventing or treating radiation damage. Background technique [0002] Dracaena cochinchinensis S.C.Chen is the red resin of Dracaena cochinchinensis S.C. Chen. It is a rare and precious medicinal material shared by traditional Chinese medicine and Dai medicine. It has a medicinal history of more than 1,500 years. A large number of research results by domestic scholars show that the main chemical components of dragon's blood are volatile oil, flavonoids, phenols, cardiac glycosides, polysaccharides, etc. At present, the functions and indications of dragon's blood mainly include anti-inflammatory and analgesic, hemostasis, promoting blood circulation and removing blood stasis, promot...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P17/16
Inventor 邓玉林金晓云孟薇薇辛念陈艳戴荣继李玉娟张信生周蜜
Owner 北京理工亘舒科技有限公司
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