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Qingkailing suppositorium

A technology of Ling suppositories and suppositories, which is applied in the field of traditional Chinese medicine compound preparations, can solve the problems that the capsule shell of Qingkailing soft capsules is easy to harden, Qingkailing oral liquid is inconvenient to carry, and the storage environment is sensitive, so as to achieve good drug compliance, Fast-acting, highly operable effects

Active Publication Date: 2008-12-24
GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, oral administration has poor compliance for some patients, especially children who are unwilling to take medicine; Qingkailing effervescent tablets are sensitive to storage environment (such as humidity) and have poor stability; Shell is also easy to harden; Qingkailing oral liquid is inconvenient to carry (fragile) etc., this all shows that existing Qingkailing dosage form also exists certain defective in actual clinical application, still be necessary to seek more practical, More ideal, new dosage forms suitable for clinics and patients

Method used

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  • Qingkailing suppositorium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The preparation of embodiment 1 Qingkailing composition I

[0058] Weigh as follows:

[0059] Cholic acid 3.25Kg

[0060] Hyodeoxycholic Acid 3.75Kg

[0061] Buffalo Horn 25Kg

[0062] Baicalin 5Kg

[0063] Mother of pearl powder 50Kg

[0064] Gardenia 25Kg

[0065] Banlangen 200Kg

[0066] Honeysuckle 20Kg

[0067] Prepare as follows:

[0068] 1. Grind the buffalo horn into powder and set aside;

[0069] 2. Add water to decoct Radix Isatidis, Fructus Fructus, and Honeysuckle twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.15-1.20 (50°C), let it cool, add an appropriate amount of ethanol, Stand still, filter, recover ethanol, dry, pulverize, and set aside;

[0070] 3. Take the buffalo horn powder and mother of pearl in the first step and add an appropriate amount of sulfuric acid, hydrolyze, filter, adjust the pH to 4 with 15% calcium hydroxide solution for the filtrate, fil...

Embodiment 2

[0072] The preparation of embodiment 2 Qingkailing composition II

[0073] Weigh as follows:

[0074] Cholic acid 3.25Kg

[0075] Hyodeoxycholic Acid 3.75Kg

[0076] Buffalo horn powder 25Kg

[0077] Baicalin 5Kg

[0078] Mother of pearl powder 50Kg

[0079] Gardenia 25Kg

[0080] Banlangen 200Kg

[0081] Honeysuckle Extract 5Kg

[0082] Prepare as follows:

[0083] 1. Add water to decoct Radix Isatidis and Gardenia twice, the first time for 1.5 hours, the second time for 1 hour, filter in several times, combine the filtrates, concentrate to a clear paste with a relative density of 1.12-1.16 (80°C), add honeysuckle to extract Let it dissolve, let it cool, slowly add ethanol under stirring, make the alcohol content reach 60%, stir fully, let it stand for 24 hours, separate the supernatant, add an appropriate amount of 60% ethanol to the precipitate, stir fully, let stand for 12 hours, separate the supernatant, combine the secondary supernatants, recover ethanol, and co...

Embodiment 3

[0087] The preparation of embodiment 3 Qingkailing composition III

[0088] Weigh as follows:

[0089] Cholic acid 3.25Kg

[0090] Hyodeoxycholic Acid 3.75Kg

[0091] Buffalo horn powder 25Kg

[0092] Baicalin 5Kg

[0093] Mother of pearl powder 50Kg

[0094] Gardenia 25Kg

[0095] Banlangen 200Kg

[0096] Honeysuckle 60Kg

[0097] Prepare as follows:

[0098] 1. Take Banlangen and add water to decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to 200L, add ethanol to make the alcohol content reach 60%, refrigerate, filter, recover ethanol from the filtrate, and refrigerate for later use;

[0099] 2. Add water and decoct twice, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, filter, the filtrate is concentrated to 25L, add ethanol to make the alcohol content reach 60%, refrigerate, filter, and filtrate Recover ethanol and store it in cold storage for later use;

[0100] 3. Decoct honeysuckle with w...

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Abstract

The invention discloses a Qingkailing suppository, relates to a Chinese medicine compound preparation, the raw materials of which mainly come from plants and animals, in particular to a novel formulation of Qingkailing preparation. The Qingkailing suppository provided by the invention for supplying rectum with medicine adopts the following components of cholic acid, hyodeoxycholic acid, baicalin, buffalo horn, the hydrolysate of mother-of-pearl, gardenia, banlangen, the water purified extract of honeysuckle as Qingkailing combination. The suppository which is 1-3g weight is made from the raw materials and supplementary materials with the following weight proportions of 8-13 proportions of Qingkailing combination, 5-50 proportions of suppository base, 0.1-5 proportions of surfactant, 0.05-3 proportions of sorbefacient, and 0-3 proportions of additional agent. The Qingkailing suppository of the invention not only can compensate the defects that the oral taking preparation is slow to take effect and injection preparation has great toxicity, but also can prolong the duration of the medicine, provides a wider selection range for clinics and sufferers, has simple production technology, is suitable for industrialized batch production, and is suitable to be taken by infants.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation mainly derived from plants and animals, in particular to a new dosage form of Qingkailing preparation. Background technique [0002] Qingkailing preparation has the effects of clearing away heat and detoxification, calming the nerves, resolving phlegm and dredging collaterals, removing blood stasis and refreshing the brain, preventing and treating hepatitis, and is widely used in clinical practice. Qingkailing is made from cholic acid, mother-of-pearl, hyodeoxycholic acid, jasmine, buffalo horn, isatidis, baicalin and honeysuckle. At present, the Qingkailing preparations that have been developed include oral preparations such as capsules, granules, effervescent tablets, tablets, oral liquids, dropping pills and soft capsules, as well as Qingkailing injections. Among them, the drug standards of Qingkailing oral liquid and injection are included in the "Chinese Pharmacopoeia" (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/02A61K47/14A61K47/34A61P1/16A61P11/04A61P11/10A61P25/20A61P31/12A61K31/575A61K35/32A61K35/56A61K47/10A61K47/26A61K47/44
Inventor 朱少璇梁超峰周焘司徒少金刘学斌杨威倪庆纯杨鹊黄子健谢志宏陈玲
Owner GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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