Preparation method for fructus lycii extract

A wolfberry extract and wolfberry technology are applied in the field of natural medicine extract preparation, can solve the problems of incomplete extraction of effective components, low oral bioavailability, waste of resources and the like, and achieve high oral bioavailability and pharmacodynamics. Obvious effect without wasting resources

Active Publication Date: 2014-02-05
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of incomplete extraction of active ingredients, low extraction rate, low oral bioavailability and waste of resources in the existing preparation method of Lycium barbarum extract, and to provide a preparation method of Lycium barbarum extract

Method used

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specific Embodiment approach 1

[0022] Specific embodiment one: the preparation method of a kind of Lycium barbarum extract of present embodiment, carry out according to the following steps:

[0023] 1. Remove impurities from Lycium barbarum and carry out purification;

[0024] 2. Pulverize the purified medlar in a frozen pulverizer and pass through a 20-mesh sieve;

[0025] 3. Put the crushed wolfberry in step 2 into supercritical CO 2 In the extraction device, extract for 1 to 3 hours, and collect the extract;

[0026] 4. Add ethanol with a mass of 4 to 6 times the volume of the dregs and a volume percentage of 60% to 80% to the dregs, reflux at 60°C to 80°C for 3 to 6 hours, filter with 200 mesh silk cloth, and collect the reflux liquid and residue;

[0027] 5. Concentrate the reflux liquid obtained in step 4 to a relative density of 1.20-1.25g / cm 3 , to obtain a concentrated solution;

[0028] 6. Add water with 4 to 6 times the quality of the residue to the residue obtained in step 4 and decoct for ...

specific Embodiment approach 2

[0038] Specific embodiment 2: This embodiment differs from specific embodiment 1 in that: in step 2, the purified Lycium barbarum is pulverized in a freeze grinder, and the freeze grind temperature is -80°C to -100°C. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0039] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the supercritical CO described in step three 2 Extraction adjustment parameters The extraction temperature is 40℃~50℃, the extraction pressure is 25~35Mpa, the extraction time is 1.5~2.5 hours, CO 2 The flow rate is 10~30L / h. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method for a fructus lycii extract, relates to a preparation method for an extract of a traditional Chinese medicinal material fructus lycii and aims to solve the problems of incomplete extraction of effective components, low extraction rate, low oral bioavailability and waste of resources in a conventional fructus lycii extract preparation method. The preparation method disclosed by the invention comprises the following steps of 1, purifying fructus lycii medicinal materials; 2, pulverizing the medicinal materials through a freezing pulverizer; 3, performing supercritical CO2 extraction; 4, performing alcohol extraction on herb residues; 5, recycling an alcohol extraction solution; 6, performing water extraction on residues; 7, concentrating a water extraction solution, and combining medicine liquids; 8, performing low-temperature depression drying on the combined medicine liquid; 9, pulverizing a dry extract through gas flow; 10, uniformly mixing the dry extract powder. The preparation method disclosed by the invention can be used for fully extracting the effective components, which can be absorbed by a human body, in the fructus lycii medicinal materials; the oral bioavailability is high; the clinical application treating effect is good; the resources cannot be wasted; the extraction rate is increased by about 30 percent than that in the conventional normal extraction method. The preparation method is mainly applied to the field of natural medicine extract preparation.

Description

technical field [0001] The invention relates to a preparation method of a Chinese medicinal material wolfberry extract, which is applied to the field of preparation of natural medicine extracts. Background technique [0002] Lycium barbarum is a plant of the genus Lycium (Lycium) in the family Solanaceae. The fruit is called Lycium barbarum, and the young leaves are called Lycium barbarum head. The common species is Lycium chinense Miller, and the main medicinal species is Lycium barbarum L.. Functions and Indications Nourishing liver and kidney, benefiting essence and improving eyesight, used for asthenia and essence deficiency, sore waist and knees, dizziness and tinnitus, internal heat and quenching thirst, blood deficiency and chlorosis, and blurred vision. Lycium barbarum contains 14 kinds of amino acids, and contains special nutrients such as betaine, maize flavin, physalis erythromycin, etc., which make it have extraordinary health care effects. Lycium barbarum is ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P39/00A61P39/06A61P3/06A61P3/10A61K131/00
Inventor 郑玥刘景国裴福成李文军肇静静尹涛
Owner 哈药集团中药有限公司
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