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Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof

A technology for chronic pelvic inflammatory disease and detection method, applied in the field of traditional Chinese medicine, can solve the problems of preparation process method and parameter screening, difficulty in preparing a stable traditional Chinese medicine composition for chronic pelvic inflammatory disease products, and lack of a set of strict and reliable quality testing standards, etc.

Active Publication Date: 2014-05-14
GUIZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process and parameters are not refined and screened in the instructions, and it is difficult to prepare a traditional Chinese medicine composition with excellent treatment effect on chronic pelvic inflammatory disease and high product stability according to the disclosed content
[0004] In addition, there is no set of strict and reliable quality testing standards for the preparations for the prevention and treatment of chronic pelvic inflammatory disease at present.

Method used

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  • Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof
  • Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof
  • Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0419] Example 1: Weigh 20g of Pulsatilla Cyperi, 20g of Rhizoma Cyperi, 12g of Achyranthes Radix, 12g of Atractylodes Rhizome, 8g of Phellodendron Phellodendri, and 8g of Cnidium Fructus; 2 Fluid extraction, collecting volatile oil to make small drop pills, the mixed matrix PEG10000:PEG20000=3:1, drug loading 60%, after the matrix is ​​melted in a water bath at 75°C, add volatile oil medicine, the temperature of the liquid medicine is 75°C, and the condensing agent Dimethicone is used Base silicone oil, refrigeration temperature 15°C, nozzle temperature 20°C, dripper diameter 2.0 / 2.5mm mm -1 , drop distance 8cm, drop speed 20d·min -1 , the dripping pills are collected and wiped dry with absorbent paper; the extracted residues of Rhizoma Cyperi and Atractylodes Rhizome are mixed with Phellodendron Phellodendron, Achyranthes bidentata, Pulsatilla and osthole coarse powder, then extracted by ethanol percolation, and the dry paste of extract is mixed with micro-powder of auxiliar...

Embodiment 2

[0420] Embodiment 2: the complete detection method of the biphasic capsule of preventing and treating chronic pelvic inflammatory disease of the present invention is:

[0421] Identification: (1) Thin-layer chromatography identification of Pulsatilla chinensis: Take 0.72g of the content of this preparation, add 20mL of methanol, dissolve it by ultrasonication, filter, evaporate the filtrate to dryness on a water bath, add 30mL of water to the residue to dissolve, and add 20mL of water-saturated n-butyl Extract with alcohol three times, 30mL each time, combine the n-butanol solution, wash the n-butanol extract twice with ammonia test solution, discard the washing solution, evaporate the n-butanol solution to dryness, add methanol 10mL to dissolve the residue, and use it as the test solution ; Take another 1.0 g of Pulsatillae reference medicinal material, and make the reference medicinal material solution in the same way; then take Pulsatilla saponin B 4 For the reference subst...

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Abstract

The invention provides a dual-phase capsule for preventing and treating chronic pelvic inflammation and a preparation method and a detection method thereof. The dual-phase capsule for preventing and treating chronic pelvic inflammation is prepared by extracting 20g of Chinese pulsatilla root, 20g of nutgrass galingale rhizome, 12g of twotooth achyranthes, 12g of Chinese atractylodes, 8g of amur corktree bark and 8g of selinum japenious seed serving as bulk pharmaceuticals, adding a proper amount of superfine silica powder and low-substituted hydroxypropyl cellulose, and adding 80 percent ethanol as a wetting agent. Aiming at the defects in the prior art, a preparation process of the dual-phase capsule for preventing and treating chronic pelvic inflammation is optimized, so that the curative effect of the dual-phase capsule on chronic pelvic inflammation is more remarkable. A systematic, complete and effective component identification and content determination method is established, so that the quality of the dual-phase capsule can be controlled effectively, and the clinical curative effect is ensured.

Description

technical field [0001] The invention relates to a biphasic capsule for preventing and treating chronic pelvic inflammatory disease, a preparation method and a detection method thereof, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Two-phase capsule refers to making small drop pills (or soft capsules) from the volatile components in the traditional Chinese medicine compound, and making granules (or micropills) from the extract, and then combining the small drop pills (or soft capsules) and granules (or micropills) ) etc. into hard capsules. This dosage form gives full play to the advantages of dropping pills, granules, and hard capsules. The advantage of this biphasic capsule is that it uses a method of packaging liquid components and solid components to solidify the liquid components, reduce the volatilization of volatile oils, and reduce the mixing of these components. The resulting chemical and physical changes are a sa...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K9/48A61P15/00G01N30/90G01N30/88
Inventor 江帆杨世林游本刚许琼明丁小艳
Owner GUIZHOU NORMAL UNIVERSITY
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