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Tumor model, preparation method for same and method for screening anti-tumor treatment protocol by virtue of tumor model

A treatment plan and anti-tumor technology, applied in the medical field, can solve the problems that cannot be directly applied to patients, cannot fully reflect the state of the original tumor tissue, and the tumor model needs to be improved, so as to avoid toxic and side effects, reduce blindness, and achieve accurate clinical efficacy Effect

Inactive Publication Date: 2015-07-15
南京普恩瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the obtained animal model cannot completely reflect the state of the original tumor tissue, and the results of drug screening often cannot be directly applied to patients, especially the cancer model obtained in this way cannot satisfy the screening of treatment options. Such as route of administration, administration cycle and dosage, etc.
[0007] Therefore, existing tumor models still need to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Tumor tissue: volume of fresh tumor tissue obtained by surgical resection or biopsy of tumor patients 1×1×1cm 3 , immediately (within 30 minutes) put into the organ preservation solution, and send to the Experimental Animal Center for transplantation within 4 hours.

[0052] Experimental animals:

[0053] Species and quantity: SCID mice,

[0054] Age and gender: 6-7 weeks old, female, weighing 17-19g

[0055] Adaptation period: 7 days

[0056] Laboratory temperature: 22°C-25°C

[0057] Relative humidity: 40%-70%

[0058] Relative air pressure: 10Pa-20Pa

[0059] Air exchange frequency: (10-15) times / hour

[0060] Light cycle: 12 hours light (8:00-20:00), 12 hours dark (20:00-8:00)

[0061] Animal husbandry: 5 animals / cage

[0062] Equipped with central air-conditioning and air filtration mechanical equipment, animal cages, drinking water, litter, drinking water, etc. are all sterilized by high-pressure steam, fed with SPF grade special pellet feed, and free to d...

Embodiment 2

[0075] This example was carried out in the same manner as in Example 1, except that mice with a body weight of 25 grams were used. As a result, it was found difficult to obtain a tumor tissue with a desired size.

Embodiment 3

[0077] This example was carried out in the same manner as in Example 1, except that mice with a body weight of 15 grams were used. As a result, it was found that the death rate of the mice was increased, and it was difficult to form tumor tissues with the desired size.

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Abstract

The invention provides a tumor model for screening an anti-tumor treatment protocol, a method for preparing the tumor model and a method for screening the anti-tumor treatment protocol by virtue of the tumor model. The tumor model is derived from a tumor tissue formed in a first organism, and is obtained by proliferating the tumor tissue formed in the first organism in a second organism, wherein the first organism is different from the second organism. By the tumor model, therapy for the first organism can be effectively screened.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to a tumor model for screening anti-tumor therapeutic regimens, a method for preparing the tumor model, and a method for using the tumor model to screen anti-tumor therapeutic regimens. Background technique [0002] Tumor is a new organism formed by the body under the action of various tumorigenic factors, and the cells of local tissues lose their normal regulation of their growth at the gene level, resulting in abnormal proliferation and differentiation. Once a new organism is formed, it does not stop growing due to the elimination of the cause. Its growth is not regulated by normal body physiology, but destroys normal tissues and organs. This is especially obvious in malignant tumors. Compared with benign tumors, malignant tumors grow faster and show invasive growth, are prone to bleeding, necrosis, ulcers, etc., and often have distant metastasis, res...

Claims

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Application Information

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IPC IPC(8): A61D1/02A61K49/00
CPCA61D1/02A61K49/00
Inventor 朱燕萍郝艳鹏何国峰
Owner 南京普恩瑞生物科技有限公司
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