A method comprising: applying pre-determined
DC voltage values to analog inputs of an analog or mixed
signal circuit design (710); applying a plurality of sets of bit values generated for scan-based
structural testing of circuits manufactured based on the
circuit design, one set during each of a plurality of consecutive time intervals, to inputs of one or more node-connecting devices coupled to or to be coupled to one or more selected internal nodes of the
circuit design, to one or more selected digital inputs of the circuit design, or both (720); and performing a
simulation of the circuit design to determine, for each set of bit values, expected
test response bit values at outputs of one or more threshold-comparing convertors and at selected
digital signal nodes if the circuit design has the selected
digital signal nodes (730). These operations may be repeated on the circuit design with defects being injected.