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Preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation

A technology of Jinmagantai and Jinmagan, which is applied in the field of preparation of medicines and Jinmagantai preparations, can solve the problems of unsatisfactory clinical efficacy of Jinmagantai granule preparations, etc.

Active Publication Date: 2012-12-12
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing methods for producing Jinmagantai granules generally adopt the method recorded in the drug standard (WS-10313(ZD-0313)-2002). The method recorded in the above standard is relatively simple, resulting in a large amount of ineffective ingredients and impurities in the product. The clinical curative effect of Jinma Gantai Granules is not ideal

Method used

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  • Preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation
  • Preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation
  • Preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Prescription: 288.2g of horseshoe gold, 153.3g of iron-coated gold, 115g of verbena, 191.6g of Fangji, 115g of Patrinia, 153.3g of Epimedium, 153.3g of Astragalus, 153.3g of Radix Paeoniae Rubra, and 230g of Salvia miltiorrhiza.

[0080] Process: The granules are prepared in the following way: crush Epimedium into coarse powder, add 30 times the amount of 70% ethanol to reflux and extract twice, each time for 1.75h, filter, recover ethanol, and concentrate the filtrate to a relative density of 50-60°C It is a thick paste of 1.34 to 1.40; the horseshoe gold is crushed into a coarse powder, refluxed and extracted with 6 times the amount of 90% ethanol for 3 times, each time for 1 hour, filtered, combined with the filtrate, recovered ethanol and concentrated to 50 to 60 °C when the relative density is 1.34 ~1.40 thick paste; Fangji dried and crushed into coarse powder, refluxed with 85% ethanol for 3 times, 1 hour each time, combined the extracts, recovered the ethanol unti...

Embodiment 2

[0084] Prescription: 300g of horseshoe gold, 200g of iron-coated gold, 150g of verbena, 250g of Fangji, 150g of Patrinia, 200g of Epimedium, 200g of Astragalus, 200g of Radix Paeoniae Rubra, 300g of Salvia miltiorrhiza.

[0085] Process: The capsules are prepared in this way: crush Epimedium into coarse powder, add 30 times the amount of 70% ethanol to reflux and extract twice, each time for 1.75h, filter, recover ethanol, and concentrate the filtrate to a relative density of 50-60°C It is a thick paste of 1.34 to 1.40; the horseshoe gold is crushed into a coarse powder, refluxed and extracted with 6 times the amount of 90% ethanol for 3 times, each time for 1 hour, filtered, combined with the filtrate, recovered ethanol and concentrated to 50 to 60 °C when the relative density is 1.34 ~1.40 thick paste; Fangji dried and crushed into coarse powder, refluxed with 85% ethanol for 3 times, 1 hour each time, combined the extracts, recovered the ethanol until it had no alcohol smell...

Embodiment 3

[0089] Prescription: 250g of horseshoe gold, 100g of iron-coated gold, 100g of verbena, 150g of Fangji, 100g of Patrinia, 100g of Epimedium, 100g of Astragalus, 100g of Radix Paeoniae Rubra, 200g of Salvia miltiorrhiza.

[0090] Process: crush Epimedium into coarse powder, add 30 times the amount of 70% ethanol to reflux and extract twice, each time for 1.75h, filter, recover ethanol, and concentrate the filtrate to a thick paste with a relative density of 1.34-1.40 at 50-60°C ; Chrysanthemum chinensis is crushed into a coarse powder, extracted 3 times with 6 times the amount of 90% ethanol under reflux, each time for 1h, filtered, combined filtrate, recovered ethanol and concentrated to a thick paste with a relative density of 1.34-1.40 at 50-60°C; Fangji After drying, crush it into a coarse powder, use 85% ethanol to reflux extract 3 times, each time for 1 hour, combine the extracts, recover the ethanol until there is no alcohol smell, add 1% hydrochloric acid drop by drop un...

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Abstract

The invention discloses a preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation, prepared from creeping dichondra, berchemia lineate, verbena, stephania root, herba patriniae, herba epimedii, milk vetch, red peony root, salviae miltiorrhizae and auxiliary materials. According to the preparation method disclosed by the invention, a preparation process is optimized according to properties of each medicine in a formula of creeping dichondra-berchemia lineata-verbena Gantai granules and the effect of the medicine in the formula; and compared with the prior art, the preparation method disclosed by the invention has the advantages that content of active ingredients of a product prepared by the preparation method disclosed by the invention is high and clinical effect is good.

Description

technical field [0001] The invention relates to a preparation method of Jinmagantai preparation, which belongs to the field of pharmaceutical technology. technical background [0002] Pain and burning in the flanks, abdominal distension and anorexia, bitter mouth and nausea, short red or yellow urine, irregular stool, or yellow body and eyes, red tongue with yellow greasy coating, and rapid pulse are common clinical symptoms. Traditional Chinese medicine often treats it by soothing the liver and nourishing blood, regulating qi and removing blood stasis. Traditional Chinese medicine believes that the lack of righteousness makes it very easy to be infected with epidemic toxins. Bad eating habits damage the spleen and stomach and cannot eliminate dampness. Or acute and chronic hepatitis caused by stagnation of qi and blood stasis due to stagnation of damp evil and long-term heat accumulated in the liver and gallbladder, damp and heat in the liver and gallbladder. The preparat...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/16A61K9/28A61K9/48A61P1/16
Inventor 黄文荣马静周菲娅
Owner GUIZHOU BAIHUA PHARMA
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