Praziquantel crystal B substance, its preparation method and its applications in medicines and healthcare products

A technology of praziquantel and substances, which is applied in the field of medicine and can solve the problems of not finding other crystal forms of praziquantel, such as patents or literature reports.

Active Publication Date: 2012-11-21
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] After searching domestic and foreign patents and literature, no other crystal form patents or literature reports related to praziquantel were found

Method used

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  • Praziquantel crystal B substance, its preparation method and its applications in medicines and healthcare products
  • Praziquantel crystal B substance, its preparation method and its applications in medicines and healthcare products
  • Praziquantel crystal B substance, its preparation method and its applications in medicines and healthcare products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation method of praziquantel crystal type B sample:

[0052] The preparation method of praziquantel crystal type B sample, the steps are to use 40ml of methanol as a solvent to completely dissolve 200mg of praziquantel sample at 20°C, remove the solvent at 40°C under vacuum pressure, and prepare the praziquantel crystal form sample.

[0053] The powder X-ray diffraction pattern of gained praziquantel crystal form sample is as attached figure 1 shown

[0054] The infrared absorption spectrum figure of gained praziquantel crystal form sample is as attached figure 2 shown

[0055] The DSC collection of illustrative plates of gained praziquantel crystal form sample is as attached image 3 shown

[0056] The results of the above spectrum data show that the crystal form of the crystal obtained in this example is praziquantel crystal type B.

Embodiment 2

[0058] The preparation method of praziquantel crystal type B sample:

[0059] The preparation method of praziquantel crystal type B sample, the steps are to use a mixed solvent of 15ml of methanol and 10ml of water to completely dissolve 230mg of praziquantel sample at a temperature of 20°C, remove the solvent at a vacuum pressure of 60°C, and prepare praziquantel A sample of quinone crystal form.

[0060] The powder X-ray diffraction pattern of gained praziquantel crystal form sample is as attached figure 1 shown

[0061] The infrared absorption spectrum figure of gained praziquantel crystal form sample is as attached figure 2 shown

[0062] The DSC collection of illustrative plates of gained praziquantel crystal form sample is as attached image 3 shown

[0063] The results of the above spectrum data show that the crystal form of the crystal obtained in this example is praziquantel crystal type B.

Embodiment 3

[0065] The preparation method of praziquantel crystal type B sample:

[0066] The preparation method of the praziquantel crystal type B sample is characterized in that the praziquantel sample is melted by a melting method and placed at a temperature of 20° C. to prepare the praziquantel crystal type sample.

[0067] The powder X-ray diffraction pattern of gained praziquantel crystal form sample is as attached figure 1 shown

[0068] The infrared absorption spectrum figure of gained praziquantel crystal form sample is as attached figure 2 shown

[0069] The DSC collection of illustrative plates of gained praziquantel crystal form sample is as attached image 3 shown

[0070] The results of the above spectrum data show that the crystal form of the crystal obtained in this example is praziquantel crystal type B.

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PUM

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Abstract

The invention discloses a praziquantel crystal B substance with the structure represented by formula (I), a preparation method of a praziquantel crystal B sample, products prepared through treating the praziquantel crystal B substance as an active component, and applications of the praziquantel crystal B in the disease control and the healthcare, wherein the products comprise medicines and healthcare products.

Description

technical field [0001] The present invention relates to a new type B crystal state of praziquantel, a method for preparing a sample of type B praziquantel crystal, a product using type B praziquantel crystal as an active ingredient, and the use of type B praziquantel crystal. It belongs to the field of medical technology. Background technique [0002] Praziquantel, English name is Praziquantel, and molecular structure is as shown in formula (I) [0003] [0004] In Chinese patent CN1414847 (publication number), it is recorded that Hong Xingtai, Li Chengjin, Gao Yuangui, and Zhu Tingzhe invented "slow-release anti-helminth composition containing praziquantel" [1] , which relates to a slow-release anti-helminth composition containing praziquantel and a preparation method. [0005] In the Chinese patent CN1452489 (publication number), it is recorded that "praziquantel compound for treating diseases caused by Sarcocystis, Neospora, Toxoplasma and Isospora" invented by T.J.K...

Claims

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Application Information

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IPC IPC(8): C07D471/04A61K31/4985A61P33/00A23L1/30
Inventor 杜冠华吕扬田硕陈芊茜
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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