Compound praziquantel parasite repellent tablet for pets and preparation method thereof

Abstract

The invention relates to a compound praziquantel parasite repellent tablet for pets. The tablet is characterized by comprising the following components by mass percent: 68-80 of praziquantel, 3-5 of ivermectin, 13-20 of starch, 1-10 of 10% starch slurry for soft material preparation, 3-6 of sodium carboxymethyl starch, and 0.5-1 of magnesium stearate. The preparation method consists of: weighing the praziquantel and the ivermectin, adding the starch, mixing them, conducting crushing and sieving to obtain a mixture; and adding the starch slurry to make a soft material, carrying out granulation with a sieve, performing drying at 50DEG C-70DEG C, subjecting the obtained dry granules to grain straightening through the sieve, adding the magnesium stearate and the sodium carboxymethyl starch, mixing them uniformly, and conducting tabletting, thus obtaining the product. With a smooth and clean appearance, the tablet provided in the invention can disintegrate rapidly, has all indicators optimized, and can achieve a good parasite repellent effect after oral administration. And the preparation method has a simple and feasible process and a low cost, thus being suitable for industrial production.

Description

technical field [0001] The invention relates to a compound praziquantel anthelmintic tablet for pets and a preparation method thereof. Background technique [0002] The first need in veterinary parasitology is the development of new antiparasitic drugs. However, the development of new drugs requires a huge amount of money, and it takes a long time for each new drug to go from research to final registration and listing. On the basis of the original drugs, developing various formulations and using existing drugs and new technologies to prepare compound preparations is a research direction in the development of new drugs. Clinical research results have proved that compound preparations have the same advantages as single-dose drugs, such as high efficacy, fewer adverse drug reactions, and convenient taking. Due to its own characteristics, pets will not use their own reason to take medicines like humans, so the appropriate dosage form is particularly important. Tablets are gen...

AI Technical Summary

Problems solved by technology

In my country, both ivermectin and praziquantel are varieties recorded in the 2005 edition of the Chinese Veterinary Pharmacopoeia, and their single preparations have been produced in large quantities, and their compound preparations have not been reported and sold yet.