Praziquantel chewable tablets for dog or cat

A technology of praziquantel and chewable tablets, applied in the field of chewable tablets, can solve problems such as poor palatability, and achieve the effects of reducing waste and improving the cure rate

Active Publication Date: 2008-06-04
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the physiological characteristics of dogs and cats, the inventor broke through the shortcomings of poor palatability of existing tablets, and developed a chewable tablet suitable f

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Praziquantel Chewable Tablets

[0019] Take 2400g of starch and bake at 100°C for 1 hour, cool to room temperature; take another 1800g of praziquantel and 60g of aspartame, dilute and mix with the cooled starch by equal amount incremental dilution method, pass through 60 mesh, and finely sieve Mixture A was obtained three times. Put mixture A, 600 g of oral glucose, 600 g of skimmed milk powder and 540 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. After mixing glycerin and absolute ethanol in a ratio of 1:10, 2.5 L was taken, and 200 g of polyvinylpyrrolidone was added thereto to prepare a polyvinylpyrrolidone glycerol-ethanol mixed solution.

[0020] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with a 16-mesh sieve and ventilate and dry at 50°C. Accur...

Embodiment 2

[0028] Embodiment 2: Praziquantel Chewable Tablets

[0029] Get 2280g of starch, 2100g of praziquantel, and 120g of aspartame to prepare mixture A according to the method described in Example 1.

[0030] Put mixture A, 375g of oral glucose, 1125g of skimmed milk powder and 270g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:5, take 2.5 L, add polyvinylpyrrolidone 200 g to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0031] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containing 0....

Embodiment 3

[0032] Embodiment 3: Praziquantel Chewable Tablets

[0033] Get 3300g of starch, 3000g of praziquantel, and 300g of aspartame, and prepare mixture A according to the method described in Example 1. Put mixture A, 300 g of oral glucose, 900 g of skimmed milk powder and 300 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:10, take 2.5 L, add polyvinylpyrrolidone 200 g to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0034] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containing 0.3g o...

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PUM

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Abstract

The invention discloses a praziquantel chewable tablet used for dogs and cats. The invention overcomes the poor palatability defect of the existing tablet to promote the thorough chewing absorption by dogs and cats, so as to effectively guarantee the medicine-supply dose, to enhance the cure rate of diseases of dogs and cats and to reduce the medicine waste. The tablet of the invention comprises the following components represented by weight-percentage: 1 to 5 percent of aspartame; 20 to 30 percent of a mixture of oral dextrose and degreased milk powder; the ratio of 1:1 to 1:4 between the oral dextrose and degreased milk powder in the mixture; 40 to 60 percent of excipient; 0.5 to 1 percent of glidant and 30 to 50 percent of praziquantel.

Description

technical field [0001] The invention relates to the preparation technology of veterinary medicine, in particular to a chewable tablet with good palatability for dogs and cats. Background technique [0002] Pet breeding has a long history in our country. With the improvement of living standards, the number of expensive dogs and cats is gradually increasing, and pet owners are paying more and more attention to the quality of life of their pets. Dogs and cats are mammals, and they also have their own common diseases. At present, the treatment of dog and cat diseases is mainly based on intravenous drip and intramuscular injection. Interruption of treatment often results in a poor prognosis of the disease. If dogs and cats can be made to actively take therapeutic drugs orally, this series of problems will be solved, but the few veterinary tablets currently on the market are often difficult to popularize because of their poor palatability. Contents of the invention [0003] A...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4985A61P33/12
Inventor 李旭东鲍恩东苏建东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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