Veterinary compound suspension injection containing ivermectin and praziquantel and preparation method thereof

A technology for suspending injection and ivermectin, which can be used in medical preparations containing active ingredients, liquid delivery, pharmaceutical formulations, etc., and can solve the problems of serious first-pass effect, long lasting effect, and short lasting effect. , to achieve the effect of expanding the range of insect resistance, high drug loading and convenient administration

Inactive Publication Date: 2013-12-04
北京中农大动物保健品技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above several compound preparations are mainly used to treat nematodes, ectoparasites and tapeworms, and are ineffective against flukes
The reason is that these compound prescriptions are all oral preparations, and the two medicines are used according to clinically recommended doses. After oral administration, ivermectin has a long half-life in animals and a long duration of action. One administration can treat nematodes and ectop

Method used

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  • Veterinary compound suspension injection containing ivermectin and praziquantel and preparation method thereof
  • Veterinary compound suspension injection containing ivermectin and praziquantel and preparation method thereof
  • Veterinary compound suspension injection containing ivermectin and praziquantel and preparation method thereof

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Embodiment 1

[0058] Embodiment 1, preparation contains the veterinary compound suspension injection containing ivermectin and praziquantel

[0059] The formula of the veterinary compound suspension injection containing ivermectin and praziquantel of the present invention is as follows:

[0060] Ivermectin 0.2kg, Praziquantel 15kg, Aluminum stearate 1kg, Span-80 0.5L， Vitamin E 0.02kg, Benzyl alcohol 0.5kg, Soybean Oil for Injection Add to 100L.

[0061] The veterinary compound suspension injection containing ivermectin and praziquantel is prepared with the present invention, and the specific method comprises the following steps:

[0062] 1) Add the formulated amount of aluminum stearate, vitamin E and benzyl alcohol into 3L of soybean oil for injection, heat and stir to dissolve completely, and obtain liquid A;

[0063] 2) Pour 60L of soybean oil for injection into the colloid mill, start the colloid mill, then slowly add the abov...

Embodiment 2

[0066] Embodiment 2, prepare the veterinary compound suspension injection containing ivermectin and praziquantel

[0067] The formula of the veterinary compound suspension injection containing ivermectin and praziquantel of the present invention is as follows:

[0068] Ivermectin 0.2kg, Praziquantel 30kg, hydrogenated castor oil 1kg, Span-80 0.5L， ascorbic acid 0.02kg, Methylparaben 0.05kg, Triacetin Add to 100L.

[0069] Prepare the veterinary compound suspension injection containing ivermectin and praziquantel with the method of the present invention, the specific method comprises the following steps:

[0070] 1) Take the formula amount of hydrogenated castor oil, ascorbic acid and methylparaben and add it to 3L triacetin glyceride, heat and stir to dissolve completely to obtain liquid A;

[0071] 2) Take 40L triacetin and pour it into the colloid mill, start the colloid mill, then slowly add the above liquid A, wait ...

Embodiment 3

[0074] Embodiment 3, preparation contains the veterinary compound suspension injection containing ivermectin and praziquantel

[0075] The formula of the veterinary compound suspension injection containing ivermectin and praziquantel of the present invention is as follows:

[0076] Ivermectin 0.2kg, Praziquantel 40kg, hydrogenated castor oil 0.3kg,

[0077] Lecithin 0.2kg, Span-80 0.6L， Butylated hydroxytoluene 0.05kg, Methylparaben 0.05kg, medium chain triglycerides 20L， ethyl oleate Add to 100L.

[0078] Prepare the veterinary compound suspension injection containing ivermectin and praziquantel with the method of the present invention, the specific method comprises the following steps:

[0079] 1) Dissolve the hydrogenated castor oil, lecithin, dibutyl hydroxytoluene and methylparaben in 3L of hot ethyl oleate to form A solution;

[0080] 2) Pour 20L of medium-chain triglycerides and 60L of ...

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Abstract

The present invention discloses a veterinary compound suspension injection containing ivermectin and praziquantel and a preparation method thereof, wherein effectively components of the veterinary compound suspension injection are ivermectin and praziquantel. The preparation method comprises the following steps: a) taking an auxiliary suspending agent, an antioxidant and a preservative, and dissolving or dispersing into 3-20% of a hot dispersion medium to obtain a solution A; 2) taking the dispersion medium and pouring into a colloid mill, opening the colloid mill, slowly adding the solution A, and adding a wetting agent while stirring after the solution A is completely added, wherein the amount of the dispersion is 30-90% of the formula amount; 3) after all the auxiliary materials are completely added, sequentially adding ivermectin and praziquantel, and adopting a cyclic grinding and acyclic grinding alternating manner to grind; and 4) checking a particle fineness, stopping grinding after meeting requirements, adding the dispersion medium until the amount achieves the formula amount, mixing, filling, sealing, and sterilizing to obtain the veterinary compound suspension injection containing ivermectin and praziquantel. The veterinary compound suspension injection containing ivermectin and praziquantel is mainly used for prevention and treatment of mixing infections caused by livestock flukes, tapeworms, threadworms and ectoparasites.

Description

technical field [0001] The invention belongs to the field of veterinary pharmaceutical preparations, in particular to a veterinary compound suspension injection containing ivermectin and praziquantel and a preparation method thereof. Background technique [0002] Parasitic diseases in pigs, cattle, and sheep in my country are quite common, showing the characteristics of high infection rate, high infection intensity, and mixed infection with trematodes, tapeworms, nematodes, and ectoparasites. At present, the main method of prevention and control of parasitic diseases is chemical control, but the research and development of new APIs with unique action mechanisms requires huge funds, and the probability of success is very small. Therefore, based on the existing old drugs, it is of great significance to make the effects of the old drugs better by changing the preparation factors or applying new drug-loading systems. At present, the widely used animal antiparasitic drugs mainly...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/10A61P33/10A61P33/12A61P33/14A61K31/4985
Inventor 肖希龙汤树生陈琳琳郭召绪
Owner 北京中农大动物保健品技术研究院
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