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Veterinary insect expelling injection containing closantel sodium and ivermectin

A technology of Closantamide Sodium and Closamide Sodium, which is applied in the field of antiparasitic drug preparations, can solve the problems of failing to get rid of Fasciola hepatica, achieve rapid killing activity, and increase the range of anti-parasites , the effect of prolonging the effective days

Inactive Publication Date: 2021-09-03
巴中市南江黄羊科学研究所南江县南江黄羊产业发展中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug effect duration of the product made by this patent is about 20 days, so the preparations containing closamide or its sodium salt that have been sold on the market are used to prevent and treat Fasciola hepatica, and once the drug is used, it often cannot reach the The purpose of completely eradicating Fasciola hepatica

Method used

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  • Veterinary insect expelling injection containing closantel sodium and ivermectin
  • Veterinary insect expelling injection containing closantel sodium and ivermectin
  • Veterinary insect expelling injection containing closantel sodium and ivermectin

Examples

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Effect test

Embodiment 1

[0039] A kind of veterinary deworming injection containing iodosamide sodium and ivermectin, it is characterized in that, every 100ml injection is made up of following composition:

[0040] Active ingredients: Cloclosamide sodium 6g, ivermectin 3g;

[0041] Aqueous solution of glycerol triacetate 20ml;

[0042] Add N-phenylpyrazole 0g;

[0043] Add other additives 0-50ml;

[0044] Add vitamin A 1g, vitamin D3 2g and vitamin E4 1g;

[0045] The rest is water.

[0046] Its preparation process is:

[0047] Take 6g of quantitative closantamide sodium, mix with 0.02ml of sodium thiosulfate and 20ml of triacetin aqueous solution and heat it, stop heating after it is completely dissolved, cool to 40°C, add alkylphenol polyoxyethylene ether 15ml, stir well to get solution A: dissolve 3g of ivermectin, add 15ml of alkylphenol polyoxyethylene ether and stir well to get solution B: mix "A" and "B" evenly, then add 2ml of aluminum stearate, hydrochloric acid 0.5ml of procaine, 4g of...

Embodiment 2

[0049] A kind of veterinary deworming injection containing iodosamide sodium and ivermectin, it is characterized in that, every 100ml injection is made up of following composition:

[0050] Active ingredients: Cloclosamide sodium 9g, ivermectin 5g;

[0051] Aqueous solution of glycerol triacetate 25ml;

[0052] Add N-phenylpyrazole 4g;

[0053] Add other additives 0-50ml;

[0054] Add vitamin A 2g, vitamin D3 4g and vitamin E4 2g;

[0055] The rest is water.

[0056] The preparation process of above-mentioned a kind of veterinary deworming injection containing iodosamide sodium and ivermectin is:

[0057] Take 9g of quantitative closantamide sodium, mix with 0.1ml of sodium thiosulfate and 30ml of triacetin aqueous solution and heat it, stop heating after it is completely dissolved, cool to 40°C, add alkylphenol polyoxyethylene ether 20ml, stir well to get solution A: dissolve 3g of ivermectin, add 20ml of alkylphenol polyoxyethylene ether and stir well to get solution B: m...

Embodiment 3

[0059] A kind of veterinary deworming injection containing iodosamide sodium and ivermectin, it is characterized in that, every 100ml injection is made up of following composition:

[0060] Active ingredients: Closamide Sodium 12g, Ivermectin 7g;

[0061] Aqueous solution of glycerol triacetate 35ml;

[0062] Add N-phenylpyrazole 15g;

[0063] Add other additives 0-50ml;

[0064] Add vitamin A 2.5g, vitamin D3 5g and vitamin E4 2.5g;

[0065] The rest is water.

[0066] The preparation process of above-mentioned a kind of veterinary deworming injection containing iodosamide sodium and ivermectin is:

[0067] Take 12g of quantitative closantamide sodium, mix with 0.25ml of sodium thiosulfate and 40ml of triacetin aqueous solution and heat it, stop heating after it is completely dissolved, cool to 40°C, add alkylphenol polyoxyethylene ether 25ml, stir well to get solution A: dissolve 7g of ivermectin, add 25ml of alkylphenol polyoxyethylene ether and stir well to get soluti...

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Abstract

The invention discloses a veterinary insect repelling injection containing closantel sodium and ivermectin, and belongs to the technical field of anti-parasitic pharmaceutical preparations. In order to solve the problem of poor insect-repelling effect of an insect-repelling injection in the prior art, each 100 millilitres of the injection of the invention is prepared from the following components: active ingredients: 6-15 grams of closantel sodium and 3-8 grams of ivermectin; 20-45 millilitres of dispersion media; 0-20 grams of N-phenylpyrazole if necessary; 0-50 millilitres of other additives if necessary; and 4-12 grams of vitamin if necessary; with the balance being water. The invention aims to provide the veterinary insect repelling injection with rapid expelling and killing activity on fasciola hepatica, coenurus cerebralis, alimentary canal nematodes, lungworms, ticks, mites and arthropods in the larva stage, and the veterinary insect repelling injection can be applied to the aspects of treating and preventing fasciola hepatica, gastrointestinal nematodes, sheep maggots and other parasites of animals, including cattle, sheep, etc.

Description

technical field [0001] The invention belongs to the technical field of antiparasitic pharmaceutical preparations, and in particular relates to a veterinary insect repelling injection containing iodosan sodium and ivermectin. Background technique [0002] Parasitic diseases are the most widely distributed, most diverse and serious diseases in the world. It not only hinders the healthy development of animal husbandry and causes significant economic losses, but also some zoonotic parasitic diseases threaten human health and affect the safety of public health. [0003] Closantamide or its sodium salt is a salicylanilide antiparasitic drug, mainly used for the prevention and treatment of fasciolasis in cattle and sheep. Abamectin is currently the most excellent and widely used broad-spectrum high-efficiency antiparasitic drug in the world. It is a group of macrolides produced by Streptomyces fermentation. Currently commercialized drugs of this type include avermectin, ivermecti...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K45/06A61K9/08A61K47/10A61P33/00A61P33/10A61P33/14A61K31/045A61K31/07A61K31/167A61K31/245A61K31/277A61K31/355A61K31/415A61K31/593
CPCA61K31/7048A61K31/277A61K31/415A61K45/06A61K9/08A61K9/0019A61K47/10A61P33/10A61P33/14A61P33/00A61K31/045A61K31/07A61K31/593A61K31/355A61K31/245A61K31/167A61K2300/00
Inventor 谭玉祥张国俊陈瑜何林芳苗斌杨明朗
Owner 巴中市南江黄羊科学研究所南江县南江黄羊产业发展中心
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