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Compound levamisole hydrochloride injection and preparation method thereof

A technology of levamisole hydrochloride and levamisole, which is applied in the field of livestock and poultry medicine, can solve the problems of increasing the labor load of breeders, organophosphorus poisoning, and waste of resources, and achieve the effects of reducing the probability of poisoning, facilitating growth, and being widely used

Inactive Publication Date: 2014-12-03
TIANJIN BIJIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs need to be suitable for use in order to drive and kill internal and external parasites. Repeated use of drugs not only wastes resources, but also increases the labor of the breeders. Moreover, for anti-ectoparasite drugs, organophosphorus or other insecticides are generally used, and the dosage is controlled. It is not good, it is easy to cause poisoning, animals lick their bodies can also cause poisoning, antibody endoparasite insecticides can also cause poisoning, and many sick animals that are treated with antibody endoparasites can also cause organophosphate poisoning

Method used

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  • Compound levamisole hydrochloride injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of compound levamisole hydrochloride injection, every 1000L injection is made of the following raw materials:

[0019] Closantamide Sodium 30kg, Levamisole Hydrochloride 1kg, Glycerol Methylal 800L, Propylene Glycol 200L.

[0020] A preparation method of compound levamisole hydrochloride injection, the steps are as follows:

[0021] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0022] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0023] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, keep for 15-20 minutes, and the compound levamisole hydrochloride injection will be obtained after the liquid is clear .

Embodiment 2

[0025] A kind of compound levamisole hydrochloride injection, every 1000L injection is made of the following raw materials:

[0026] Closantamide Sodium 100kg, Levamisole Hydrochloride 20kg, Glycerol Methylal 950L, Propylene Glycol 50L.

[0027] A preparation method of compound levamisole hydrochloride injection, the steps are as follows:

[0028] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0029] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0030] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, keep for 15-20 minutes, and the compound levamisole hydrochloride injection will be obtained after the liquid is clear .

Embodiment 3

[0032] A kind of compound levamisole hydrochloride injection, every 1000L injection is made of the following raw materials:

[0033] Closantamide Sodium 80kg, Levamisole Hydrochloride 15kg, Glycerol Methylal 900L, Propylene Glycol 100L.

[0034] A preparation method of compound levamisole hydrochloride injection, the steps are as follows:

[0035] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0036] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0037] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, keep for 15-20 minutes, and the compound levamisole hydrochloride injection will be obtained after the liquid is clear .

[0038] Clinical Trials:

[0039] 1. Experimental animals:

[0040] Randomly select 100 diseased adult cattle with a body weight of 250-500kg.

[0041] 2. Experimental drug:

[0042] Compound levamisole hyd...

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Abstract

The invention relates to a compound levamisole hydrochloride injection and a preparation method thereof. The preparation method comprises the following steps of 1, putting closantel sodium salt into propylene glycol, heating the mixture to a temperature of 50-60 DEG C, and carrying out stirring for 10-20min for clarification, 2, taking a part of glycerolformal, adding the glycerolformal into levamisole hydrochloride and carrying out stirring for dissolution, and 3, merging the solutions obtained by the steps 1 and 2, adding the rest of the glycerolformal into the mixed solution until the mixed solution has a volume of 1000L, carrying out stirring to obtain a uniform mixture, and carrying out maintenance for 15-20min until the preparation is clear so that a finished product is obtained. Through compounding of closantel sodium salt and levamisole hydrochloride, the problem of an insufficient pest-resistant scope is solved. The compound levamisole hydrochloride injection has high effects of killing cattle and sheep parasites, increases a parasite-resistant range, reduces cattle and sheep infection probability and is conducive to growth.

Description

technical field [0001] The invention relates to the field of livestock and poultry medicine, in particular to a compound levamisole hydrochloride injection and a preparation method thereof. Background technique [0002] Cattle and sheep parasitic infection is an extremely susceptible disease to cattle and sheep, which can cause problems such as poor growth, increased feed consumption, and decreased resistance of cattle and sheep. Cattle and sheep parasites are composed of trematodes, roundworms, hookworms, tapeworms and other internal parasites and some external parasites such as: lice, maggots, mites, etc. The traditional anti-parasite drugs such as closantamide sodium injection and levamisole hydrochloride injection have certain limitations in driving and killing parasites, such as closantamide sodium anthelmintic drug, which is effective for fasciola hepatica, gastrointestinal nematodes and sheep typhoid, but not effective for mites ; Levamisole hydrochloride has a killi...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61K9/08A61P33/00A61K31/277
Inventor 张伟
Owner TIANJIN BIJIA BIOTECH
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