Compound closantel sodium injection and preparation method thereof

The technology of compound iolosamide sodium cyanide and iolosamide sodium cyanide is applied in the field of livestock and poultry medicine, which can solve the problems of increasing the labor of breeders, organophosphorus poisoning, waste of resources and the like, so as to reduce the probability of poisoning, Good for growth and wide application

Inactive Publication Date: 2011-04-27
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs need to be suitable for use in order to drive and kill internal and external parasites. Repeated use of drugs not only wastes resources, but also increases the labor of the breeders. Moreover, for anti-ectoparasite drugs, organophosphorus or other insecticides are generally used, and the dosage is controlled. It is not good, it is easy to cause poisoning, animals lick their bodies can also cause poisoning, antibody endoparasite insecticides can also cause poisoning, and many sick animals that are treated with antibody endoparasites can also cause organophosphate poisoning

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  • Compound closantel sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of compound iodosamide sodium injection, every 1000L injection is made of the following raw materials:

[0019] Closantamide Sodium 30kg, Levamisole Hydrochloride 1kg, Glycerol Methylal 800L, Propylene Glycol 200L.

[0020] A kind of preparation method of compound iodosan sodium injection, the steps are as follows:

[0021] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0022] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0023] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, and keep for 15-20 minutes. After the liquid is clear, the compound clocyansamide is obtained Sodium Injection.

Embodiment 2

[0025] A kind of compound iodosamide sodium injection, every 1000L injection is made of the following raw materials:

[0026] Closantamide Sodium 100kg, Levamisole Hydrochloride 20kg, Glycerol Methylal 950L, Propylene Glycol 50L.

[0027] A kind of preparation method of compound iodosan sodium injection, the steps are as follows:

[0028] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0029] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0030] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, and keep for 15-20 minutes. After the liquid is clear, the compound clocyansamide is obtained Sodium Injection.

Embodiment 3

[0032] A kind of compound iodosamide sodium injection, every 1000L injection is made of the following raw materials:

[0033] Closantamide Sodium 80kg, Levamisole Hydrochloride 15kg, Glycerol Methylal 900L, Propylene Glycol 100L.

[0034] A kind of preparation method of compound iodosan sodium injection, the steps are as follows:

[0035] (1) Put Closamide Sodium into propylene glycol, heat to 50-60°C and stir for 10-20 minutes until clear;

[0036] (2) Get 200L of glycerin formal, add levamisole hydrochloride and stir to dissolve;

[0037] (3) Combine the solutions prepared by "(1)" and "(2)", add glycerin methylal to 1000L, stir evenly, and keep for 15-20 minutes. After the liquid is clear, the compound clocyansamide is obtained Sodium Injection.

[0038] Clinical Trials:

[0039] 1. Experimental animals:

[0040] Randomly select 100 diseased adult cattle with a body weight of 250-500kg.

[0041] 2. Experimental drug:

[0042] Compound Closantamide Sodium Injection de...

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Abstract

The invention relates to a compound closantel sodium injection and a preparation method thereof. The compound closantel sodium injection is prepared from components in the following steps: (1) putting closantel sodium into propanediol, heating to 50-60 DEG C, and stirring for 10-20 min until solution is clarified; (2) taking partial glycerol acetal and adding levamisole hydrochloride to stir and dissolve; and (3) mixing the solutions prepared in the step (1) and the step (2), adding the rest glycerol acetal until the solution reaches 1,000 L, uniformly stirring, keeping for 15-20 min and clarifying the liquid medicine to obtain a finished product. The invention complements the defects of narrow anti-parasite range by adopting the compound preparation of the closantel sodium and the levamisole hydrochloride, is effective and efficient on killing cow and sheep parasites, expands the anti-parasite range, reduces the cow and sheep illness and is favorable to the cow and sheep growth.

Description

technical field [0001] The invention relates to the field of livestock and poultry medicines, in particular to a compound iodosalamide sodium injection and a preparation method thereof. Background technique [0002] Cattle and sheep parasitic infection is an extremely susceptible disease to cattle and sheep, which can cause problems such as poor growth, increased feed consumption, and decreased resistance of cattle and sheep. Cattle and sheep parasites are composed of trematodes, roundworms, hookworms, tapeworms and other internal parasites and some external parasites such as: lice, maggots, mites, etc. The traditional anti-parasite drugs such as closantamide sodium injection and levamisole hydrochloride injection have certain limitations in driving and killing parasites, such as closantamide sodium anthelmintic drug, which is effective for fasciola hepatica, gastrointestinal nematodes and sheep typhoid, but not effective for mites ; Levamisole hydrochloride has a killing e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/429A61K31/277A61K9/08A61P33/00
Inventor 裴毅聂江力李华声马明娟
Owner TIANJIN BIJIA PHARMA CO LTD
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