Veterinary compound suspension injection containing ivermectin and praziquantel and preparation method thereof

Abstract

The present invention discloses a veterinary compound suspension injection containing ivermectin and praziquantel and a preparation method thereof, wherein effectively components of the veterinary compound suspension injection are ivermectin and praziquantel. The preparation method comprises the following steps: a) taking an auxiliary suspending agent, an antioxidant and a preservative, and dissolving or dispersing into 3-20% of a hot dispersion medium to obtain a solution A; 2) taking the dispersion medium and pouring into a colloid mill, opening the colloid mill, slowly adding the solution A, and adding a wetting agent while stirring after the solution A is completely added, wherein the amount of the dispersion is 30-90% of the formula amount; 3) after all the auxiliary materials are completely added, sequentially adding ivermectin and praziquantel, and adopting a cyclic grinding and acyclic grinding alternating manner to grind; and 4) checking a particle fineness, stopping grinding after meeting requirements, adding the dispersion medium until the amount achieves the formula amount, mixing, filling, sealing, and sterilizing to obtain the veterinary compound suspension injection containing ivermectin and praziquantel. The veterinary compound suspension injection containing ivermectin and praziquantel is mainly used for prevention and treatment of mixing infections caused by livestock flukes, tapeworms, threadworms and ectoparasites.

Description

technical field [0001] The invention belongs to the field of veterinary pharmaceutical preparations, in particular to a veterinary compound suspension injection containing ivermectin and praziquantel and a preparation method thereof. Background technique [0002] Parasitic diseases in pigs, cattle, and sheep in my country are quite common, showing the characteristics of high infection rate, high infection intensity, and mixed infection with trematodes, tapeworms, nematodes, and ectoparasites. At present, the main method of prevention and control of parasitic diseases is chemical control, but the research and development of new APIs with unique action mechanisms requires huge funds, and the probability of success is very small. Therefore, based on the existing old drugs, it is of great significance to make the effects of the old drugs better by changing the preparation factors or applying new drug-loading systems. At present, the widely used animal antiparasitic drugs mainly...

AI Technical Summary

Problems solved by technology

[0004] However, the above several compound preparations are mainly used to treat nematodes, ectoparasites and tapeworms, and are ineffective against flukes

The reason is that these compound prescriptions are all oral preparations, and the two medicines are used according to clinically recommended doses. After oral administration, ivermectin has a long half-life in animals and a long duration of action. One administration can treat nematodes and ectoparasitic diseases, while pyrimectin Quinone has serious first-pass effect after oral administration, short half-life, and short duration of effect in the body. The curative effect is not satisfactory when only one drug is used to treat trematodes and tapeworms

At present, the praziquantel preparations available in my country's veterinary drug market, whether they are single preparations or compound preparations, all have the defect of short half-life

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