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Compound preparation for expelling in-vivo and in-vitro parasites from dogs and cats and preparation method thereof

A compound preparation and parasite technology, which is applied to the compound preparation and its preparation of internal and external parasites in cats, in the field of expelling dogs, and can solve the problems of ineffective arthropod parasites and other problems

Inactive Publication Date: 2011-01-05
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] First of all, macrolide drugs focus on nematodes in animals and arthropod parasites parasitic in the skin, but are ineffective against trematodes and tapeworms; But it is ineffective against arthropod parasites that live in the skin

Method used

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  • Compound preparation for expelling in-vivo and in-vitro parasites from dogs and cats and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Prescription (1000 tablets)

[0032] Mebemycin oxime 20g, praziquantel 50g, lactose 55g, microcrystalline cellulose 60g, hydroxypropyl cellulose 12g, micropowder silica gel 2.5g, talcum powder 1.5g

[0033] (2) Process

[0034] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. Take by weighing 20g of mebemycin oxime, 50g of praziquantel, 55g of lactose, 60g of microcrystalline cellulose, and 12g of hydroxypropyl cellulose, and adopt the method of increasing in equal amounts to fully mix the raw and auxiliary materials, and pass through a 60-mesh sieve; For soft materials, pass through a 40-mesh sieve, dry below 80°C, and granulate with a 30-mesh sieve; add the prescribed amount of micronized silica gel and talcum powder, and mix thoroughly; measure the intermediates, calculate the weight of the tablet, and pack it into the warehouse after tableting.

Embodiment 2

[0036] (1) Prescription (1000 tablets)

[0037] Mebemycin oxime 20g, praziquantel 50g, lactose 75g, microcrystalline cellulose 90g, hydroxypropyl cellulose 60g, micropowder silica gel 2.5g, talcum powder 1.5g

[0038] (2) Process

[0039] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. Take by weighing 20g of mebemycin oxime, 50g of praziquantel, 75g of lactose, 90g of microcrystalline cellulose, 60g of hydroxypropyl cellulose, adopt the method of increasing in equal amount to fully mix the raw and auxiliary materials, and pass through a 60-mesh sieve; Make soft materials, pass through a 40-mesh sieve, dry below 80°C, and granulate with a 30-mesh sieve; add the prescribed amount of micro-powdered silica gel and talcum powder, and mix well; perform intermediate determination, calculate the weight of the tablet, and pack it into the warehouse after tableting .

Embodiment 3

[0041] (1) Prescription (1000 tablets)

[0042] Mebemycin oxime 20g, praziquantel 50g, lactose 65g, microcrystalline cellulose 80g, hydroxypropyl cellulose 90g, micropowder silica gel 2.5g, talcum powder 1.5g

[0043] (2) Process

[0044] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. Take by weighing 20g of mebemycin oxime, 50g of praziquantel, 65g of lactose, 80g of microcrystalline cellulose, and 90g of hydroxypropyl cellulose, and adopt the method of increasing in equal amounts to fully mix the raw and auxiliary materials, and pass through a 60-mesh sieve; Make soft materials, pass through a 40-mesh sieve, dry below 80°C, and granulate with a 30-mesh sieve; add the prescribed amount of micro-powdered silica gel and talcum powder, and mix well; perform intermediate determination, calculate the weight of the tablet, and pack it into the warehouse after tableting .

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Abstract

The invention relates to a compound preparation for expelling in-vivo and in-vitro parasites from dogs and cats and a preparation method thereof. The compound preparation mainly comprises milbemycin oxime and praziquantel, wherein the milbemycin oxime is a novel and specific 16-membered ring macrolide medicament for preventing and controlling the in-vivo and in-vitro parasites of the dogs and the cats, which can specially prevent and control heartworms and efficiently prevent and control in-vivo parasites such as hookworms, roundworms, whipworms, belly worms and the like and in-vitro parasites such as hair follicle mites, scabies, louses, fleas and the like; and the praziquantel is effective to nematodes, trematodes and tapeworms in animal bodies. The milbemycin oxime and the praziquantel expel the parasites complementarily. The two medicaments are combined, so that a parasite expelling range is expanded and one-step parasite expelling effect is improved. The invention also provides a method for preparing compound tablets. The tablets prepared by the method can be released rapidly and dispersed fully.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a compound preparation for expelling internal and external parasites in dogs and cats and a preparation method thereof. Background technique [0002] With the development of the world economy and the improvement of people's living standards, there has been a pet craze in developed and developing countries. Over the past ten years in my country, the pet industry has developed rapidly across the country, and more and more pet dogs and cats have entered common people's families. The keeping of dogs and cats, the most closely related pets, not only adds fun to people’s lives, but also poses a threat to human health, because dogs and cats can transmit many zoonotic parasitic diseases, pathogens include protozoa, worms And arthropods that can burrow or enter the host's skin or parasitize the body. According to literature search, there are at least 39 kinds of parasitic d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985A61K31/365A61P33/00A61P33/14
Inventor 霍俊凤
Owner TIANJIN RINGPU BIO TECH
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