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Medical sodium alginate gel microsphere and preparation method and application thereof

A technology of sodium alginate and gel microspheres is applied in the directions of non-active ingredients medical preparations, pharmaceutical formulations, endocrine system diseases, etc., to achieve the effects of improving chemical stability, controlling sustained release, and improving molecular cross-linking effect.

Inactive Publication Date: 2013-08-14
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Another object of the present invention is to provide a preparation method of the medical sodium alginate gel microspheres, using a new ion cross-linking process to solve the problem of divalent cation cross-linked sodium alginate gel microspheres in production and packaging. and many problems in application

Method used

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  • Medical sodium alginate gel microsphere and preparation method and application thereof
  • Medical sodium alginate gel microsphere and preparation method and application thereof
  • Medical sodium alginate gel microsphere and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0032] 1. Preparation of gel microspheres containing rifabutin-calcium alginate-aminomethylbenzoic acid. The preparation method comprises the following steps:

[0033] (1) After passing the rifabutin powder through a 160-mesh sieve, weigh 4 g for later use.

[0034] (2) 1.5 g of sodium alginate was weighed and dissolved in 100 mL of distilled water to obtain a sodium alginate solution with a concentration of 1.5 wt%.

[0035] (3) Weigh 2 g of 4-aminomethylbenzoic acid, add it into 200 mL of distilled water, and stir at room temperature to obtain a 4-aminomethylbenzoic acid solution with a concentration of 1%.

[0036] (4) Weigh 8 g of anhydrous calcium chloride, add it into 400 mL of distilled water, and stir at room temperature to obtain a calcium chloride solution with a concentration of 2%.

[0037] (5) 200 mL of the 4-aminomethylbenzoic acid solution obtained in step (3) was mixed in equal volumes with 200 mL of the calcium chloride solution obtained in step (4), and stir...

Embodiment 2

[0053] The preparation of paclitaxel-loaded sodium alginate gel microspheres comprises the following steps:

[0054] (1) After passing the paclitaxel powder through a 160-mesh sieve, weigh 2 g.

[0055] (2) Weigh 2 g of sodium alginate and dissolve it in 100 mL of distilled water to obtain a sodium alginate solution with a concentration of 2.0 wt%.

[0056] (3) Weigh 1 g of 4-aminomethylbenzoic acid, add it into 200 mL of distilled water, and stir at room temperature to obtain a 4-aminomethylbenzoic acid solution with a concentration of 0.5%.

[0057] (4) Weigh 6 g of anhydrous calcium chloride, add it into 400 mL of distilled water, and stir at room temperature to obtain a calcium chloride solution with a concentration of 1.5%.

[0058] (5) Mix 200 mL of the 4-aminomethylbenzoic acid solution obtained in step (3) with 200 mL of the calcium chloride solution obtained in step (4) in equal volumes, and stir at room temperature to obtain a composite coagulation solution.

[005...

Embodiment 3

[0062] The preparation of sodium alginate gel microspheres loaded with 17β-estradiol comprises the following steps:

[0063] (1) After passing the 17β-estradiol powder through a 160-mesh sieve, weigh 1 g.

[0064] (2) Weigh 2 g of sodium alginate and dissolve it in 100 mL of distilled water to obtain a sodium alginate solution with a concentration of 2.0 wt%.

[0065] (3) Weigh 1 g of 4-aminomethylbenzoic acid, add it into 200 mL of distilled water, and stir at room temperature to obtain a 4-aminomethylbenzoic acid solution with a concentration of 0.5%.

[0066] (4) Weigh 8 g of anhydrous calcium chloride, add it into 400 mL of distilled water, and stir at room temperature to obtain a calcium chloride solution with a concentration of 2%.

[0067] (5) 200 mL of the 4-aminomethylbenzoic acid solution obtained in step (3) was mixed with 200 mL of the calcium chloride solution obtained in step (4) in equal volumes, and stirred at room temperature to obtain a composite coagulation...

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Abstract

The invention provides a medical sodium alginate gel microsphere and a preparation method and application of the medical sodium alginate gel microsphere. The medical sodium alginate gel microsphere consists of a composite medicine carrier and a water-insoluble medicine; the medicine is coated with the composite medicine carrier; and the composite medicine carrier is an ion crosslinking agent-sodium alginate-divalent metal ion, wherein the ion crosslinking agent is 4-aminomethylbenzoic acid or tranexamic acid. The preparation method comprises the following steps of: (1) mixing ion crosslinking agent aqueous solution with divalent metal ion solution in the same volume to obtain composite solidifying liquid; (2) dispersing medicine powder or an agent into sodium alginate aqueous solution; uniformly mixing; dropwise adding the mixture into the composite solidifying liquid obtained in step (1) through a high-voltage static droplet generating device or a syringe needle, so that the mixture drops are solidified into spheres; and (3) dehydrating gel microspheres which are washed with the distilled water; and drying at normal temperature. The medical sodium alginate gel microsphere can be used for treating tuberculosis, endocrine disease and tumor, and also can be used for treating local acute hemorrhage and chronic errhysis.

Description

technical field [0001] The invention relates to a medical sodium alginate gel microsphere, a preparation method and application thereof. Background technique [0002] Since O'Shea et al. made sodium alginate-polylysine-sodium alginate (APA) microspheres (capsules) in 1986, the microspheres have become the most mature medical treatment due to their good biocompatibility. Microspheres (capsules) (O'Shea GM, Sun AM. Encapsulation of rat islets of Langerhans prolongs xenograft survival in diabetic mice. [J]. J Am Diabetes Assoc, 1986, 35: 943.). In recent years, people have tried to use other methods and materials to develop new medical microspheres (capsules) to improve some of the biological and chemical properties of the microspheres, so that microsphere technology can be used in the treatment of metabolic diseases, drug sustained release control, and in vivo And in vitro cell culture and other fields have been widely used. [0003] Alginate is an anionic polyelectrolyte po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61P7/04A61K9/16A61P5/00A61K47/36A61P31/06
Inventor 黎望黎立张广宇杨楠
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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