52 results about "Intestinal mucous membrane" patented technology

The invention provides oral liquid for alleviating a hangover and protecting a liver, and a preparation method thereof. The oral liquid is prepared from the following components in parts by weight: 5-15 parts of root of kudzu vine, 5-15 parts of semen hoveniae, 0.5-5 parts of ginseng, 2-10 parts of lalang grass rhizome, 0-5 parts of hawthorn, 0-3 parts of sealwort, 0-15 parts of pueraria flower, 3-20 parts of glucose, 1-10 parts of xylitol, 1-5 parts of L-arabinose, 0.2-1.0 part of taurine, 0-0.5 parts of glutamine, 0-5 parts of resistant dextrin, 0-1 part of decavitamin, and 0-2 parts of compound amino acid. The oral liquid has the beneficial effects of good hangover alleviating efficacy and good flavor and mouthfeel; the problems of dizzy giddy and scattered attention after excessive drinking are solved; damages to the liver and kidney caused by alcohol are reduced; and gastrointestinal mucosa is protected.

The invention discloses use of supported nano zinc oxide as an anti-diarrhea agent for weaned pigs and a using method. According to the use of the supported nano zinc oxide as the anti-diarrhea agent for the weaned pigs, the supported nano zinc oxide is a composite material for supporting nano zinc oxide by using kaolin or montmorillonite or attapulgite or sepiolite or zeolite as a supporter. The zinc oxide accounts for 10 to 50 weight percent of the composite material for supporting the nano zinc oxide. The using method of the supported nano zinc oxide serving as the anti-diarrhea agent for the weaned pigs comprises that 160 to 800 mg/kg of supported nano zinc oxide based on zinc is added into a weaned pig feed. The supported nano zinc oxide can remarkably reduce the diarrhea rate of the weaned pigs, improve the daily gain, improve the form of the intestinal mucous membrane and protect the intestinal mucous membrane barrier; the fur of the pigs is red and bright; the toxic or side effect of high-zinc daily ration on the pigs is avoided; and the effect of the supported nano zinc oxide exceeds that of high-dose common zinc oxide, the consumption of the zinc oxide is greatly reduced, and zinc excretion and environmental pollution are reduced.

The invention discloses a process for preparing heparin sodium through membrane separation. The process comprises the steps: intestinal mucosa enzymolysis, ceramic membrane filtration, ion exchange column chromatography, nanofiltraiton membrane concentration, alcohol precipitation and drying, wherein the optimal condition for the intestinal mucosa enzymolysis is formed by the proper proportion of intestinal mucosa to water, enzymolysis temperature and pH value of a system. A protease can take the optimal enzymolysis effect, the structure and activity of heparin are not damaged when the glucosidic bond linked between protein and the heparin is hydrolyzed, meanwhile, fewer low-molecular heparins are generated, the activity of the heparin can be improved by 20%, and the generated low-molecular heparins can be reduced by 10%. Due to the adoption of the ceramic membrane filtration, protein impurities and the heparin in an enzymatic hydrolysate can be effectively separated, so that the heparin loss is greatly reduced and can be reduced by 5-8% as comparison with that of the traditional process, the production cost is reduced, the discharged wastewater can be reduced by 50-60%, the resin utilization ratio can be increased by 40-50%, the consumption of auxiliary materials is low, the quality of the heparin sodium is stable, the process is convenient to operate, and the defects such as high impurity content in the enzymatic hydrolysate, serious waste liquid discharge pollution, high personnel utilization rate and the like are overcome.

The invention relates to the technical field of medical apparatuses and in particular to a double-balloon porous spherical-head anal tube which comprises an anal tube (1), two balloons (2) and an air-pressure indicating balloon (3), wherein the anal tube is divided into a head part (1.1) and a body part (1.2), the head part of the anal tube is in the shape of a porous spherical surface, a drainage hole (1.3) is respectively arranged at the top and the periphery of the spherical surface, and the body part (1.2) of the anal tube is tubular; and the two balloons (2) are sequentially wrapped on the outer wall of the body part on the rear edge of the head part of the anal tube, the charging tubes (2.1) of the two balloons are respectively buried in the tube wall of the body part of the anal tube, and the other ends are respectively dissociated outside the tube wall of the body part of the anal tube to be connected with the air-pressure indicating balloon (3). The head part of the anal tube is in the shape of the porous spherical surface, the periphery of the anal tube is round and smooth, and the anal tube has less damage to a rectal mucous membrane when inserted; the drainage hole (1.3) is convenient for loose stools to flow into the anal tube and beneficial to the air discharge of abdominal distension patients; the alternate charging and discharging of the two balloons can prevent an intestinal mucous membrane from being damaged; a pressure tester can be used for monitoring the pressure in the balloons at any time and can be used for controlling the charging quantity of the balloons; and a numerically-controlled balloon pressure monitoring instrument also can be adopted, so that the operation can be more scientific and convenient.

The present invention relates to CpG DNA, and is especially specific chicken CpG ODN and its use as the H5-subtype bird flu DNA vaccine adjuvant. The CpG ODN sequence is 5í»-TTGGAACGTTCCTTTCCAACGTTGGTTTGGAACGTTCCTT-3í». The H5-subtype bird flu DNA vaccine with the CpG ODN adjuvant is taken by chicken through oral taking or nose dropping to immunize, and can raise the protection rate against the challenge virus and the intestinal mucous membrane IgA antibody level of chicken obviously. The DNA vaccine of the present invention has the advantages of safety, no interference on the monitoring of bird flu epidemic situation, capacity of overcoming the interference of maternal antibody, use convenience, etc.

The invention discloses a lactic acid bacterium composition for protecting the gastrointestinal mucosa. The lactic acid bacterium composition comprises the following components in parts by weight: 5-20 parts of bifidobacterium lactis, 0.5-2 parts of bifidobacterium infantis, 8-25 parts of lactobacillus rhamnosus, 3-20 parts of lactobacillus acidophilus, 3-20 parts of lactobacillus plantarum and 8-25 parts of lactobacillus salivarius. The invention further discloses a processing method for the lactic acid bacterium composition. The processing method comprises the following steps: (1), preparing sclerotia; (2), embedding non-reducing sugar; (3), embedding skimmed milk; and (4), freeze-drying. The lactic acid bacterium composition provided by the invention has the advantages of adjusting gastrointestinal microorganisms to be balanced and protecting the gastrointestinal mucosa.

The invention relates to a medicine for treating chronic nonspecific ulcerative colitis and a preparation method thereof, which pertain to the field of traditional Chinese medicines; the medicine is prepared from crude drugs with the following parts by weight: 840 to 870 parts of Chinese pulsatilla root, 410 to 440 parts of parslane herb, 410 to 440 parts of amur corktree bark, 100 to 130 parts of costustoot, 270 to 300 parts of radix salviae miltiorrhizae and 70 to 100 parts of cutch. The medicine can significantly improve the symptoms of rats with ulcerative colitis repair mucous membrane of colon, with fast and strong effect.

The invention discloses a method for removing impurities in a coarse heparin product by using a ceramic membrane. The method comprises the following steps: mixing intestinal mucosa with water and then adding NaCl and protease to carry out enzymolysis; filtering by a ceramic membrane after filtering enzymatic hydrolysate; eluting exchange resin after carrying out ion exchange on the clear liquor; and adding ethanol to eluent and then standing, participating, dewatering and drying, so as to obtain the coarse heparin product. By adopting a dynamic cross flow filtration mode, the enzymatic hydrolysate flows at a high speed on the surface of an inside membrane of a ceramic membrane tube at a certain flow rate; and enabling the enzymatic hydrolysate to penetrate a microporous membrane along the direction vertical to the ceramic membrane, intercepting macromolecular proteins by the membrane, so that the enzymatic hydrolysate and the impurities are separated and purified. The method is high in separation accuracy, and high in filtering efficiency, the yield of the product can be up to 99.5%, and the enzymatic hydrolysate has the advantages of being clear, lower in impurity content, free of heparin loss, convenient and fast for later adsorption and the like. The impurities in the extraction process of the coarse heparin product can be furthest removed under the condition that the heparin is not lost, the quality and the yield of the product are ensured, and the method is reasonable in production cost and applicable to large-scale industrial production.

The invention relates to a production method and application of a nutgall effective part used for preventing and treating periodontal disease and inflammatory bowel disease. The production method is characterized by carrying out the following steps: taking a nutgall medicinal material; smashing the nutgall medicinal material; refluxing and extracting the smashed nutgall for 1-5 times in the presence of solvents (ethanol water and ethyl acetate), wherein extraction is carried out for 1-5 hours every time; mixing extract; carrying out column chromatography on the obtained mixed extract with polyamide resin or macroporous adsorption resin on exchange equipment; carrying out liquid chromatography-mass spectrometry determination and collecting fraction with the mass-to-charge ratio of 321 +/- 1and 635 +/- 1, and drying to thus obtain the nutgall effective part. The obtained nutgall effective part can strengthen teeth and gingival and is used for alleviating sore and weak teeth, chewing disability, looseness and displacement, gingival bleeding, mouth and tongue sores as well as swelling and pain in throat which are caused by the periodontal disease; and the nutgall effective part also can alleviate diarrhea and abdominal pain, mucus and bloody purulent stool as well as intestinal mucosal injury which are caused by the inflammatory bowel disease.

Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.

The invention discloses a combined technology for extracting heparin sodium and intestinal membrane protein from small intestines of pigs and obtaining finished product casing. According to the technology, in an extraction process, extraction raw materials resin and ethanol are recycled; by scraping intestinal mucosa on small intestines of pigs, heparin sodium is adsorbed by a resin after enzymolysis of porcine pancreas, and a purified heparin sodium product is obtained after salt solutions with different concentrations and ethanol precipitation; continuous enzymolysis is performed on the supernatant, and then membrane concentration and drying are performed to obtain high-purity intestinal membrane protein; and leakage detection and pickling are performed on casings to obtain finished product casings. Raw materials of small intestines of pigs in the Chinese slaughter industry are easy to obtain, the operation mechanization degree is high, the raw materials can be recycled, the sausagecasing utilization rate is high, the method is suitable for large-scale industrial production, and the obtained heparin sodium and intestinal membrane protein are high in purity, good in economic benefit and wide in prospect.

The invention discloses a compound preparation capable of effectively improving the disease resistance of aquatic animals and a preparation method thereof. The compound preparation comprises the following components in parts by mass: 55-65 parts of microbial powder, 10-15 parts of astragalus polysaccharide, 10-15 parts of yeast cell walls, 5-10 parts of plant essential oil and 1-5 parts of vitaminB6. The coordination of the components is capable of reforming the intestinal flora structure, changing the proportion of unsaturated fatty acids in metabolic products of intestinal acid-producing bacteria, inhibiting enteric pathogenic bacteria and other harmful substances, restoring intestinal mucous membranes, promoting digestion and absorption of nutrients, simultaneously enabling animal bodies to have enhanced nonspecific immunity, enhanced stress resistance and stronger resistivity to viruses, pathogenic bacteria, parasites and polluted environments, comprehensively improving the utilization ratio of feed and survival rate of the animal bodies, reducing residual feed, purifying excrement and optimizing and normalizing an intensive culture mode.

The invention discloses an application to preparation of a gastrointestinal mucosa repair protective agent by using ANKRD22 as a target. The ANKRD22 is used as the target, namely gene knock-out, geneknock-out and reduction or chemicals can reduce expression of an ANKRD22 gene. The invention provides a new target for repair of gastrointestinal mucosa light and moderate injury, namely ANKRD22 geneexpression is restrained, so that stomach tissue LGR5+ stem cells can be amplified, a stomach tissue inflammatory reaction can be alleviated, and the stomach mucosa secretion can be increased.

The invention relates to a method for constructing an intestinal mucositis animal model. The method comprises the following steps of carrying out flora inoculation on the intestinal tract of an animal sample to induce the intestinal tract of the animal sample to generate inflammation, carrying out character observation, physiological and biochemical index detection and rectal middle section mucosa tissue structure microscopic observation on an inoculated mouse, when bloody stool or mucus stool appears in the mouse, and physiological and biochemical indexes related to inflammatory factors rise, or the middle section of rectum mucosa tissue skin lesion or inflammation infiltration symptoms appear, successfully constructing the intestinal mucositis animal model. Through a controlled-release or slow-release intestinal suppository application mode, uncontrollable factors generated in the application process are solved, the operation of bacterial liquid inoculation is unified and simplified, and the construction of the intestinal mucositis animal model can be repeated.

The present invention relates to a method of extracting proteins and amino acids from enzymolysis waste liquid of a porcine small intestinal mucous membrane. The method belongs to a sewage treatment industry engineering technology in chemical and biological fields. The purpose of the invention is to seek a method which not only can process biochemical waste liquid and recycle feed-grade proteins and amino acids to turn waste into wealth, but also can recycle reuse water and make sewage meet the environmental protection requirements, i.e., up-to-standard discharging. The method has remarkable advantages that proteins and lipids are precipitated by two food-grade celluloses from water through flocculation, the product can be used as a feed; microfiltration and nanofiltration are adopted to remove various substances with molecular weight greater than 300 from water; amino acids are adsorbed by resins; and activated carbon is used to deodorizing so as to make the saline solution can be recycled and largely reduce the COD value of the sewage. Moreover, the method can process all sewage with the similar properties, has good investment prospects, operability and economical efficiency, and is an ideal choice for processing the present type of sewage.

The invention discloses a dried porcine soluble product and a production method thereof. The production method of the dried porcine soluble product comprises the following steps of heating an intestinal mucosa solution as a raw material for sterilization, and enabling protein to be flocculated; enabling the heated intestinal mucosa solution to stand in a specially made container to remove a supernatant, and performing concentration; crushing protein tissues, and performing an enzymolysis reaction; performing heating for enzyme denaturalixation, and extracting heparin sodium; performing negative pressure concentration; performing spray drying; and performing packaging. The dried porcine soluble product comprises the following components of water of which the content is 6.0-10.0wt%, crude protein of which the content is greater than or equal to 50.0wt%, crude fat of which the content is smaller than or equal to 3.0wt%, crude ash of which the content is smaller than or equal to 18.0wt%, table salt of which the content is smaller than or equal to 5.0wt%, free ammonia of which the content is smaller than or equal to 1.0wt%, and small peptide which is smaller than 2000 dalton and of which the content is greater than or equal to 10.0wt%, and protein hydrolysate which is greater than or equal to 45.0wt%. According to the dried porcine soluble product and the production method thereof disclosed by the invention, the free ammonia is removed by a standing method, so that the free ammonia in the dried porcine soluble can be effectively removed, besides, waste water cannot be produced, and the treatment cost is low; the supernatant after high-temperature sterilization is used as probiotics solid state fermentation nutrient fluid for soybean meal, so that pollution is not caused, and the sewage treatment cost is reduced.

The invention discloses a gastrointestinal pressure reducer with adjustable pressure. The gastrointestinal pressure reducer comprises an upper cover, a lower cover, a cylindrical barrel and a negativepressure suction spring, a sealed negative pressure suction cavity is formed among the upper cover, the lower cover and the cylindrical barrel; the gastrointestinal pressure reducer is characterizedin that a first ventilation seat and a second ventilation seat are arranged on the upper cover, ventilation holes are formed in the first ventilation seat and the second ventilation seat, the ventilation hole in the first ventilation seat is communicated with the gastrointestinal tract, and the ventilation hole in the second ventilation seat is connected with a pressure regulator used for regulating the maximum pressure in the negative pressure suction cavity. According to the gastrointestinal pressure reducer, the pressure in the negative pressure suction cavity can be limited within a set range, the negative pressure can be adjusted to be large to drain gastric contents of a patient, small negative pressure is adopted to drain intestinal contents of the patient, and the technical problems that intestinal mucosa damage and intestinal wall perforation are likely to be caused due to the fact that the same negative pressure is adopted in existing gastrointestinal drainage are solved.

The invention especially discloses a piglet creep feed without porcine homologous protein. The piglet creep feed without porcine homologous protein is prepared from the following ingredients in percentage by weight: 10-15% of wheat, 25-30% of puffed corn granules, 20-25% of oat, 1-3% of functional fiber, 1-3% of soybean oil, 10-13% of full-fat soybeans, 5-8% of Herring meal, 3-5% of concentrated whey protein, 5-8% of skimmed milk powder, 7-10% of whey, 0.1-0.2% of lysine hydrochloride, 0.1-0.2% of methionine, 0.5-1% of glucose, 0.6-1% of calcium hydrogen phosphate, 0.4-0.8% of limestone, 0.05-0.2% of table salt, 0.5-1.5% of multi-vitamin multi-mineral additive, 0.3-0.9% of acidulating agent, 0.1-0.2% of sweetener and 0.2-0.3% of zinc oxide. According to the invention, the Herring meal, the concentrated whey protein, the skimmed milk powder and the whey are rationally proportioned so as to replace plasma protein powder and intestinal mucosal protein; therefore, palatability as well as high digestibility and utilization rates are ensured for the piglet creep feed without porcine homologous protein, so that the piglets can be fed on feed instead of breast milk successfully. The piglet creep feed is capable of avoiding diarrhea and maintaining relatively good growth performances of the piglets.

The present invention relates to a composition for preventing or treating mucositis comprising NecroX. It was found that NecroX has effects of reducing the disease mortality rate by means of radiotherapy or chemotherapy in a NecroX administration group, protecting intestinal functions, inhibiting destruction of intestinal mucous membrane, and proliferating the cells present in intestines. NecroX may be used for a pharmaceutical composition for preventing or treating mucositis, an anti-cancer adjuvant, or a food composition.

The invention belongs to the technical field of biscuits, and particularly discloses a mulberry yogurt and carrot containing biscuit for promoting gastrointestinal health. The mulberry yogurt and carrot containing biscuit is prepared from the following raw materials: mulberry yogurt, carrot, fresh carrot tassel, flour, chestnut kernel, astragalus polysaccharide, camellia seed oil and pine pollen.The mulberry yogurt and carrot containing biscuit is unique in flavor, slightly sour and sweet and easy to digest and absorb, can effectively promote nutrition metabolism of a human body, degrade specific saccharides on epithelial cells of intestinal mucosae, prevent adhesion and invasion of pathogenic bacteria and toxins into the epithelial cells, inhibit breeding of gastrointestinal harmful bacteria, promote proliferation of beneficial bacteria, effectively promote absorption of vitamins and minerals, promote healthy and strong growth of bones of infants and young children, promote growth and development of immune organs, enhance immunity, improve disease resistance, promote metabolism of skin cells, effectively inhibit occurrence of a chapped skin phenomenon and make skin smooth and tender.

The invention discloses an application of araboxylan or a compound of the araboxylan and konjaku flour to preparation of foods, health care products or medicines for preventing/treating alcoholic gastrointestinal mucosa and liver injury. The araboxylan is prepared by pretreating plant raw materials to remove impurities and then performing alkali liquor extraction, dealkalization and purification. In the compound of the araboxylan and the konjaku flour, the mass ratio of the araboxylan accounts for 1-99%. The foods, the health care products or the medicines for preventing/treating the alcoholic gastrointestinal mucosa and liver injury are prepared from the araboxylan alone or the compound of the araboxylan and the konjaku flour, so that the injury of alcohol to the gastrointestinal mucosa and the liver can be effectively reduced.

The present invention refers to a composition for use in the prevention and/or treatment of orogastrointestinal mucositis induced by oncologic treatments. It also refers to the use of said composition for preparing a medicament for the prevention and/or treatment of said orogastrointestinal mucositis. Furthermore, it refers to a method of preventing and/or treating of said orogastrointestinal mucositis in which said composition is administered to a subject in need thereof.

This present invention relates to the use of eicosapentaenoic acid (EPA) for the treatment of ulcerative colitis (UC), and more particularly, the use of highly purified eicosapentaenoic acid as free fatty acids (EPA-FFA) having a purity of at least 95% for reducing inflammation in a subject suffering from ulcerative colitis and wherein the levels of IL-10 and SOCS3 are increased and the microbiome of the intestinal mucosal tissue is favorably modulated.