13 results about "Intestinal mucous membrane" patented technology

The application belongs to the technical field of biological medicine, and particularly discloses application of Lactobacillus delbrueckii surface protein DUF4430 in preparation of a medicine for improving symptoms of ulcerative colitis, and preventing and / or treating ulcerative colitis. The application provides a new use of the Lactobacillus delbrueckii surface protein DUF4430, including application in preparation of a medicine for improving symptoms of ulcerative colitis, and preventing and / or treating ulcerative colitis. Animal experiments show that the Lactobacillus delbrueckii surface protein DUF4430 can relieve DSS-induced ulcerative colitis in mice, improve weight loss, shorten colon length, and reduce colon mucosal injury, reduce the content of pro-inflammatory cytokines (such as IL-1β and IL-6) in the colon, increase the content of anti-inflammatory cytokines (such as IL-10), reduce the proportion of pro-inflammatory macrophages in the spleen and colon, and inhibit the pro-inflammatory phenotype of macrophages, and therefore can be used for preparing a medicine for improving symptoms of ulcerative colitis, and preventing and treating ulcerative colitis.

1. The name of this design product: Four-chamber two-balloon tube. 2. Purpose of the product with this design: used for jejunal nutrition, gastric decompression, and prevention of intestinal and gastric mucosal damage. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The application belongs to the field of biomedical materials, targeted drug delivery technology and ulcerative colitis treatment, and discloses a curcumin-loaded claspable composite microneedle and a preparation method thereof. The composite microneedle comprises a curcumin-loaded gelatin hemisphere base and a curcumin-loaded chitosan-polyvinyl alcohol microneedle, and the microneedle is located on the circular end face of the hemisphere base. The curcumin in the base and the microneedle is loaded in the form of curcumin-cyclodextrin inclusion compound. The claspable composite microneedle is formed by designing a hemisphere base + microneedle array, and the hemisphere base + microneedle part of the composite microneedle is loaded with curcumin, which can relieve and treat intestinal wall and intestinal mucosa damage caused by ulcerative colitis, indirectly inhibit intestinal flora disorder and abnormal activation of the inflammatory immune system, so as to solve the technical problem of low cure rate of ulcerative colitis, and provide a more safe and efficient treatment strategy for targeted intestinal diseases.

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

The technical problem to be solved by the utility model is to provide the disposable traditional Chinese medicine rectum dripping device which can realize dripping speed adjustment, reduce risks of infection and intestinal mucosa injury, keep constant temperature of liquid medicine and effectively protect privacy of a patient. The device comprises a liquid storage bag, a heat preservation device is arranged on the outer side of the liquid storage bag, a liquid adding pipe is arranged at the upper end of the liquid storage bag, a liquid adding funnel is arranged on the liquid adding pipe, a breathable temperature measuring hole is formed in the upper end of the liquid storage bag, a first hanging rope is arranged on the liquid storage bag, and a liquid injection pipe is arranged at the lower end of the liquid storage bag. A dripping speed adjusting device and a position adjuster are arranged on the liquid injection tube, a privacy protection device is arranged on the position adjuster, the device can control the dripping speed of liquid medicine and conveniently control the depth of the lower end of the liquid injection tube extending into the rectum, and the situation that the lower end of the liquid injection tube cannot reach a good treatment effect due to deep or too shallow depth is avoided; and the privacy of the patient during liquid dropping is effectively protected through the arranged privacy protection device.

The application discloses a use of a ganoderma lucidum spore and grifola frondosa composition in preparation of a preparation for assisting in relieving colorectal cancer. The composition comprises ganoderma lucidum spore oil, squalene, grifola frondosa extract, selenium-rich yeast and the like, and is prepared into soft capsules by using a cold preparation method. A mouse model experiment induced by AOM / DSS proves that the soft capsules can significantly relieve weight loss of mice, reduce a disease activity index, improve colon shortening, inhibit expression of inflammatory factors TNF-alpha and IL-6 in serum and colon tissues, reduce intestinal inflammatory reactions, repair colon crypt structure and intestinal mucosal damage, down-regulate expression of a proliferation marker Ki 67, up-regulate expression of an apoptosis marker Caspase-3, induce tumor cell apoptosis, regulate intestinal flora structure, restore relative abundance of Bacteroidetes and Firmicutes, and reverse abnormal increase of Verrucomicrobia. The application can act on the whole process from intestinal polyps, precancerous lesions to colorectal cancer development, is safe and stable, can be taken for a long time, and has high application value.

The application discloses a biological membrane material, a preparation method thereof and an artificial heart valve. The preparation method of the biological membrane material comprises the following steps: S100, providing a biological membrane, wherein the biological membrane is derived from pericardium, blood vessels, intestinal mucosa or ligament; S200, applying a pulling force to the biological membrane, wherein at least one to-be-processed area of the biological membrane has two opposite side edges as force receiving parts, the pulling force is applied to the two side edges in opposite directions, and each side edge is provided with integral fixation or multiple fixation positions arranged along the extension direction of the side edge; and S300, performing cross-linking treatment on the biological membrane under the pulling force to obtain the biological membrane material. The biological membrane is kept in a stretched and tensioned state by applying the pulling force in the same direction as the fiber direction of the biological membrane, and the thickening effect of the biological membrane during the cross-linking treatment can be effectively inhibited.

The invention belongs to the technical field of feed processing, and particularly relates to a mastacembelus armatus feed containing a Chinese pulsatilla root extract and a preparation method thereof. The mastacembelus armatus feed containing the Chinese pulsatilla root extract is mainly prepared from the following raw materials: white fish meal, extruded soybeans, modified starch, beer yeast, fish oil, soybean oil, soybean lecithin, choline chloride, vitamin C phosphate, monocalcium phosphate, L-alanine, a vitamin and mineral premix, the Chinese pulsatilla root extract and the like. The Mastacembelus armatus feed prepared by the invention not only can significantly improve the growth performance and feed utilization efficiency of Mastacembelus armatus, but also can enhance the defense barrier function of intestinal mucosa of Mastacembelus armatus and relieve intestinal stress injury, and can effectively solve the problem of intestinal inflammation in current Mastacembelus armatus culture. Meanwhile, the feed for the mastacembelus armatus can also improve the adaptive capacity of the mastacembelus armatus to environmental changes, improve the overwintering survival rate of the mastacembelus armatus and promote the development of the artificial breeding industry of the mastacembelus armatus.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses radix scutellariae enema liquid No.2 and a preparation method thereof.The radix scutellariae enema liquid No.2 is prepared from, by weight, 25-35 g of cortex phellodendri, 15-25 g of fructus forsythiae, 15-25 g of herba taraxaci, 20-30 g of radix et rhizoma rhei, 15-25 g of radix scutellariae, 25-35 g of radix sanguisorbae, 25-35 g of radix sophorae flavescentis, 15-25 g of flos lonicerae, 15-25 g of cacumen biotae charcoal, 10-20 g of indigo naturalis and 3-8 g of mirabilite. The preparation method comprises the following steps: soaking the raw materials in water for 15-25 minutes in a traditional Chinese medicine decocting machine, extracting for 35-45 minutes under micro pressure, subpackaging into packaging bags, sterilizing for 25-35 minutes at the high temperature of 100 DEG C, and storing in a dark place at the low temperature of 20 DEG C or below. The traditional Chinese medicine preparation has the beneficial effects that through the pharmacological action and comprehensive action of the traditional Chinese medicinal materials, the effects of clearing away heat and toxic materials, purging intense heat and drying dampness, relieving pain and eliminating stagnation, cooling blood and stopping bleeding, astringing to arrest diarrhea, purging heat and relaxing bowels, moistening dryness and softening hard mass and the like can be achieved; the traditional Chinese medicine composition is suitable for patients with symptoms such as intestinal mucosa erosion, ulcer formation, more hemorrhagic spots and more purulent bloody stool caused by chronic non-specific ulcerative colitis, and the treatment effect is remarkable.

The invention discloses application of a gingko armillaria mellea oral solution in preparation of a medicine for preventing and treating inflammatory bowel diseases. Through a prevention and treatment test of the ginkgo armillaria mellea oral solution on mouse ulcerative colitis, a C57BL / 6 mouse DSS induction method is adopted to construct a model, and the effect of 390mg / kg and 780mg / kg of the ginkgo armillaria mellea oral solution on resisting mouse inflammatory bowel diseases is evaluated. The result shows that the gingko armillaria mellea oral solution can obviously improve the mouse hematochezia condition; the colon length is increased, the colon weight / length ratio is reduced, and colonic mucosa hyperemia is reduced; the weight is increased. Therefore, the gingko armillaria mellea oral solution has the characteristics of high efficiency and low toxicity for preventing and / or treating inflammatory bowel diseases.

The invention discloses a traditional Chinese veterinary medicine composition for up-regulating intestinal barrier regulatory factors. The traditional Chinese veterinary medicine composition is prepared from the following components: sanguisorba officinalis, pericarpium citri reticulatae, pericarpium granati and tea powder. The weight part ratio of the sanguisorba officinalis, the pericarpium citri reticulatae, the pericarpium granati and the tea powder is (5-10): (5-10): (1-5): (1-5). The traditional Chinese veterinary medicine composition is wide in medicinal material source, low in cost, free of toxic and side effects and free of drug resistance; through reasonable compatibility of the components, expression of mucous membrane tight junction protein and mucoprotein of animal intestinal tracts in the weaning period can be effectively promoted, so that the function of the intestinal mucous membrane barrier is remarkably improved, and the diarrhea rate and the death rate of animals in the weaning period are reduced. The traditional Chinese veterinary medicine composition is simple in preparation method and convenient to use, can become a potential medicine for preventing and treating diarrhea of weaned animals, and particularly has a cost advantage and a wide application prospect in the fields of green breeding and antibiotic substitution.

The application discloses a Lacticaseibacillus paracasei W1 and application of the Lacticaseibacillus paracasei W1 in inhibition of Clostridioides difficile infection, relates to the technical field of probiotic application, and has the technical points that the preservation number of the Lacticaseibacillus paracasei W1 is CCTCC No:M 2024619. The Lacticaseibacillus paracasei W1 has the ability of resisting low pH and high concentration of bile salts in the gastrointestinal tract, and sterile fermentation supernatant of the Lacticaseibacillus paracasei W1 can inhibit growth and biofilm formation of Clostridioides difficile. Animal experiments show that the Lacticaseibacillus paracasei W1 can inhibit colonization of Clostridioides difficile in vivo, improve colon mucosal injury, relieve colon shortening, and reduce inflammation caused by Clostridioides difficile infection. The strain has a wide application prospect in the application in preparation of a medicine for inhibiting Clostridioides difficile infection.