52 results about "Intestinal mucous membrane" patented technology

The invention provides oral liquid for alleviating a hangover and protecting a liver, and a preparation method thereof. The oral liquid is prepared from the following components in parts by weight: 5-15 parts of root of kudzu vine, 5-15 parts of semen hoveniae, 0.5-5 parts of ginseng, 2-10 parts of lalang grass rhizome, 0-5 parts of hawthorn, 0-3 parts of sealwort, 0-15 parts of pueraria flower, 3-20 parts of glucose, 1-10 parts of xylitol, 1-5 parts of L-arabinose, 0.2-1.0 part of taurine, 0-0.5 parts of glutamine, 0-5 parts of resistant dextrin, 0-1 part of decavitamin, and 0-2 parts of compound amino acid. The oral liquid has the beneficial effects of good hangover alleviating efficacy and good flavor and mouthfeel; the problems of dizzy giddy and scattered attention after excessive drinking are solved; damages to the liver and kidney caused by alcohol are reduced; and gastrointestinal mucosa is protected.

The invention provides an internal tectorial membrane for duodenum, and relates to a built-in degradable medical instrument in a digestive tract. The internal tectorial membrane can be made of biocompatible materials by electrospinning. The internal tectorial membrane is placed in the duodenum of a patient, not only can stop food from contacting with the intestinal mucosae of the patient during dissection, but also avoids affecting functions of cells of the intestinal mucosae physiologically, can be obtained by hybrid electrospinning or / and multi-layered electrospinning or / and core-shell electrospinning or / and dry-method electrospinning, and can be manufactured into a medical instrument which can reduce injury, prevent dropping, avoid being removed and restrain bounce and can be used for treating diabetes mellitus and adiposis.

The invention discloses use of supported nano zinc oxide as an anti-diarrhea agent for weaned pigs and a using method. According to the use of the supported nano zinc oxide as the anti-diarrhea agent for the weaned pigs, the supported nano zinc oxide is a composite material for supporting nano zinc oxide by using kaolin or montmorillonite or attapulgite or sepiolite or zeolite as a supporter. The zinc oxide accounts for 10 to 50 weight percent of the composite material for supporting the nano zinc oxide. The using method of the supported nano zinc oxide serving as the anti-diarrhea agent for the weaned pigs comprises that 160 to 800 mg / kg of supported nano zinc oxide based on zinc is added into a weaned pig feed. The supported nano zinc oxide can remarkably reduce the diarrhea rate of the weaned pigs, improve the daily gain, improve the form of the intestinal mucous membrane and protect the intestinal mucous membrane barrier; the fur of the pigs is red and bright; the toxic or side effect of high-zinc daily ration on the pigs is avoided; and the effect of the supported nano zinc oxide exceeds that of high-dose common zinc oxide, the consumption of the zinc oxide is greatly reduced, and zinc excretion and environmental pollution are reduced.

The invention discloses application of lactobacillus reuteri in replacement of feed antibiotic and belongs to the field of microorganisms and application of the microorganisms. The lactobacillus reuteri is obtained through separation from healthy piglets, and therefore safety is high. The bacterial strain is added into antimicrobial-free feed so as to well prevent the piglets from diarrhea after ablactation, and has a good effect on growth promotion. The bacterial strain can obviously promote repair of intestinal mucous membrane damage caused by ablactation of the piglets, and has an immunity-adjusting function. In this way, the lactobacillus reuteri can be used for resisting diarrhea of the piglets after ablactation and promoting growth as a substitude of antibiotics.

The invention discloses a process for preparing heparin sodium through membrane separation. The process comprises the steps: intestinal mucosa enzymolysis, ceramic membrane filtration, ion exchange column chromatography, nanofiltraiton membrane concentration, alcohol precipitation and drying, wherein the optimal condition for the intestinal mucosa enzymolysis is formed by the proper proportion of intestinal mucosa to water, enzymolysis temperature and pH value of a system. A protease can take the optimal enzymolysis effect, the structure and activity of heparin are not damaged when the glucosidic bond linked between protein and the heparin is hydrolyzed, meanwhile, fewer low-molecular heparins are generated, the activity of the heparin can be improved by 20%, and the generated low-molecular heparins can be reduced by 10%. Due to the adoption of the ceramic membrane filtration, protein impurities and the heparin in an enzymatic hydrolysate can be effectively separated, so that the heparin loss is greatly reduced and can be reduced by 5-8% as comparison with that of the traditional process, the production cost is reduced, the discharged wastewater can be reduced by 50-60%, the resin utilization ratio can be increased by 40-50%, the consumption of auxiliary materials is low, the quality of the heparin sodium is stable, the process is convenient to operate, and the defects such as high impurity content in the enzymatic hydrolysate, serious waste liquid discharge pollution, high personnel utilization rate and the like are overcome.

The invention relates to the technical field of medical apparatuses and in particular to a double-balloon porous spherical-head anal tube which comprises an anal tube (1), two balloons (2) and an air-pressure indicating balloon (3), wherein the anal tube is divided into a head part (1.1) and a body part (1.2), the head part of the anal tube is in the shape of a porous spherical surface, a drainage hole (1.3) is respectively arranged at the top and the periphery of the spherical surface, and the body part (1.2) of the anal tube is tubular; and the two balloons (2) are sequentially wrapped on the outer wall of the body part on the rear edge of the head part of the anal tube, the charging tubes (2.1) of the two balloons are respectively buried in the tube wall of the body part of the anal tube, and the other ends are respectively dissociated outside the tube wall of the body part of the anal tube to be connected with the air-pressure indicating balloon (3). The head part of the anal tube is in the shape of the porous spherical surface, the periphery of the anal tube is round and smooth, and the anal tube has less damage to a rectal mucous membrane when inserted; the drainage hole (1.3) is convenient for loose stools to flow into the anal tube and beneficial to the air discharge of abdominal distension patients; the alternate charging and discharging of the two balloons can prevent an intestinal mucous membrane from being damaged; a pressure tester can be used for monitoring the pressure in the balloons at any time and can be used for controlling the charging quantity of the balloons; and a numerically-controlled balloon pressure monitoring instrument also can be adopted, so that the operation can be more scientific and convenient.

The present invention relates to CpG DNA, and is especially specific chicken CpG ODN and its use as the H5-subtype bird flu DNA vaccine adjuvant. The CpG ODN sequence is 5í»-TTGGAACGTTCCTTTCCAACGTTGGTTTGGAACGTTCCTT-3í». The H5-subtype bird flu DNA vaccine with the CpG ODN adjuvant is taken by chicken through oral taking or nose dropping to immunize, and can raise the protection rate against the challenge virus and the intestinal mucous membrane IgA antibody level of chicken obviously. The DNA vaccine of the present invention has the advantages of safety, no interference on the monitoring of bird flu epidemic situation, capacity of overcoming the interference of maternal antibody, use convenience, etc.

The invention relates to a feed additive capable of reducing incidence of blood pots in fresh eggs. The technical scheme is that 1000kg of basal feed comprises the following additive components by weight percent: 50-250g of Origanum Oil, 50-100g of vitamin C, 20g of vitamin A, 1.6g of vitamin K and a premix which contains 10% of Origanum Oil. The additive in the invention not only can obviously reduce the incidence of blood pots in fresh eggs, but also can protect the intestinal mucosa, fallopian tubes and uterine mucous membrane of layers and reduce the generation of oaritis, salpingitis and other inflammations.

The invention discloses a lactic acid bacterium composition for protecting the gastrointestinal mucosa. The lactic acid bacterium composition comprises the following components in parts by weight: 5-20 parts of bifidobacterium lactis, 0.5-2 parts of bifidobacterium infantis, 8-25 parts of lactobacillus rhamnosus, 3-20 parts of lactobacillus acidophilus, 3-20 parts of lactobacillus plantarum and 8-25 parts of lactobacillus salivarius. The invention further discloses a processing method for the lactic acid bacterium composition. The processing method comprises the following steps: (1), preparing sclerotia; (2), embedding non-reducing sugar; (3), embedding skimmed milk; and (4), freeze-drying. The lactic acid bacterium composition provided by the invention has the advantages of adjusting gastrointestinal microorganisms to be balanced and protecting the gastrointestinal mucosa.

The invention relates to an additive for synergetically promoting multiplication and colonization of intestinal probiotics and a use method of the additive. The additive contains xylooligosaccharide, clostridium butyricum and high fulvic acid sodium humate, wherein the xylooligosaccharide is capable of supplying nutrients to the clostridium butyricum and promoting the multiplication of the multiplication in intestinal tracts; the clostridium butyricum is capable of secreting vitamins, growth factors and the like so as to promote the multiplication of the probiotics and simultaneously secreting organic acid, antibacterial peptide and the like so as to inhibit the growth of harmful bacteria; and the high fulvic acid sodium humate is capable of repairing the injury of intestinal mucosa, increasing the level of an probiotics adhesin receptor on the surface of intestinal mucosa and promoting the colonization of the probiotics in the intestinal tracts. By virtue of process coupling and function synergy of the xylooligosaccharide, the clostridium butyricum and high fulvic acid sodium humate, the intestinal microecological balance of beasts and birds is finally realized, the shielding and absorbing functions of the intestinal tracts are enhanced, the diarrhea rate is decreased, the feed utilization rate is increased, and furthermore, the dependence on antibiotics in a cultivation process is reduced.

The invention relates to a medicine for treating chronic nonspecific ulcerative colitis and a preparation method thereof, which pertain to the field of traditional Chinese medicines; the medicine is prepared from crude drugs with the following parts by weight: 840 to 870 parts of Chinese pulsatilla root, 410 to 440 parts of parslane herb, 410 to 440 parts of amur corktree bark, 100 to 130 parts of costustoot, 270 to 300 parts of radix salviae miltiorrhizae and 70 to 100 parts of cutch. The medicine can significantly improve the symptoms of rats with ulcerative colitis repair mucous membrane of colon, with fast and strong effect.

The invention discloses a method for removing impurities in a coarse heparin product by using a ceramic membrane. The method comprises the following steps: mixing intestinal mucosa with water and then adding NaCl and protease to carry out enzymolysis; filtering by a ceramic membrane after filtering enzymatic hydrolysate; eluting exchange resin after carrying out ion exchange on the clear liquor; and adding ethanol to eluent and then standing, participating, dewatering and drying, so as to obtain the coarse heparin product. By adopting a dynamic cross flow filtration mode, the enzymatic hydrolysate flows at a high speed on the surface of an inside membrane of a ceramic membrane tube at a certain flow rate; and enabling the enzymatic hydrolysate to penetrate a microporous membrane along the direction vertical to the ceramic membrane, intercepting macromolecular proteins by the membrane, so that the enzymatic hydrolysate and the impurities are separated and purified. The method is high in separation accuracy, and high in filtering efficiency, the yield of the product can be up to 99.5%, and the enzymatic hydrolysate has the advantages of being clear, lower in impurity content, free of heparin loss, convenient and fast for later adsorption and the like. The impurities in the extraction process of the coarse heparin product can be furthest removed under the condition that the heparin is not lost, the quality and the yield of the product are ensured, and the method is reasonable in production cost and applicable to large-scale industrial production.

The invention relates to a production method and application of a nutgall effective part used for preventing and treating periodontal disease and inflammatory bowel disease. The production method is characterized by carrying out the following steps: taking a nutgall medicinal material; smashing the nutgall medicinal material; refluxing and extracting the smashed nutgall for 1-5 times in the presence of solvents (ethanol water and ethyl acetate), wherein extraction is carried out for 1-5 hours every time; mixing extract; carrying out column chromatography on the obtained mixed extract with polyamide resin or macroporous adsorption resin on exchange equipment; carrying out liquid chromatography-mass spectrometry determination and collecting fraction with the mass-to-charge ratio of 321 + / - 1and 635 + / - 1, and drying to thus obtain the nutgall effective part. The obtained nutgall effective part can strengthen teeth and gingival and is used for alleviating sore and weak teeth, chewing disability, looseness and displacement, gingival bleeding, mouth and tongue sores as well as swelling and pain in throat which are caused by the periodontal disease; and the nutgall effective part also can alleviate diarrhea and abdominal pain, mucus and bloody purulent stool as well as intestinal mucosal injury which are caused by the inflammatory bowel disease.

Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.

The invention discloses a combined technology for extracting heparin sodium and intestinal membrane protein from small intestines of pigs and obtaining finished product casing. According to the technology, in an extraction process, extraction raw materials resin and ethanol are recycled; by scraping intestinal mucosa on small intestines of pigs, heparin sodium is adsorbed by a resin after enzymolysis of porcine pancreas, and a purified heparin sodium product is obtained after salt solutions with different concentrations and ethanol precipitation; continuous enzymolysis is performed on the supernatant, and then membrane concentration and drying are performed to obtain high-purity intestinal membrane protein; and leakage detection and pickling are performed on casings to obtain finished product casings. Raw materials of small intestines of pigs in the Chinese slaughter industry are easy to obtain, the operation mechanization degree is high, the raw materials can be recycled, the sausagecasing utilization rate is high, the method is suitable for large-scale industrial production, and the obtained heparin sodium and intestinal membrane protein are high in purity, good in economic benefit and wide in prospect.

The invention discloses an application to preparation of a gastrointestinal mucosa repair protective agent by using ANKRD22 as a target. The ANKRD22 is used as the target, namely gene knock-out, geneknock-out and reduction or chemicals can reduce expression of an ANKRD22 gene. The invention provides a new target for repair of gastrointestinal mucosa light and moderate injury, namely ANKRD22 geneexpression is restrained, so that stomach tissue LGR5+ stem cells can be amplified, a stomach tissue inflammatory reaction can be alleviated, and the stomach mucosa secretion can be increased.

The invention belongs to the technical field of duck cultivation, in particular to a muscovy duck breeding method capable of improving muscovy duck meat quality. The specific method comprises the following steps of: selecting strongly growing muscovy ducks of 1 week for breeding, giving feed twice per day, allowing the feeding amounts of each time to be equal, feeding nutritional juice four times per day, and allowing the feeding amounts of each time to be equal. The digestion and absorption of the muscovy ducks on nutrient substances are effectively improved; the food utilization efficiency is improved; a feed conversion rate is reduced; immunologic functions of the muscovy ducks are improved; an intestinal tissue structure is improved; intestinal micro-ecological balancing is adjusted; effects of restoring and protecting intestinal mucous membranes and improving mucous membrane immunity of the muscovy ducks are exerted; healthy and quick growth of the muscovy ducks is promoted; furthermore, the water-holding capacity and tenderness of duck meat tissues are effectively improved; duck meat is succulent, tender, tasty and refreshing, palatefull, and delicious and fragrant in flavor; a protein content is higher; a nutritional value and a taste of the meat are effectively improved; in addition, the disease resistance and anti-stress ability can be further effectively improved; diseases are effectively inhibited; and higher economic benefits are brought to farmers.

The invention relates to a method for constructing an intestinal mucositis animal model. The method comprises the following steps of carrying out flora inoculation on the intestinal tract of an animal sample to induce the intestinal tract of the animal sample to generate inflammation, carrying out character observation, physiological and biochemical index detection and rectal middle section mucosa tissue structure microscopic observation on an inoculated mouse, when bloody stool or mucus stool appears in the mouse, and physiological and biochemical indexes related to inflammatory factors rise, or the middle section of rectum mucosa tissue skin lesion or inflammation infiltration symptoms appear, successfully constructing the intestinal mucositis animal model. Through a controlled-release or slow-release intestinal suppository application mode, uncontrollable factors generated in the application process are solved, the operation of bacterial liquid inoculation is unified and simplified, and the construction of the intestinal mucositis animal model can be repeated.

The present invention relates to a method of extracting proteins and amino acids from enzymolysis waste liquid of a porcine small intestinal mucous membrane. The method belongs to a sewage treatment industry engineering technology in chemical and biological fields. The purpose of the invention is to seek a method which not only can process biochemical waste liquid and recycle feed-grade proteins and amino acids to turn waste into wealth, but also can recycle reuse water and make sewage meet the environmental protection requirements, i.e., up-to-standard discharging. The method has remarkable advantages that proteins and lipids are precipitated by two food-grade celluloses from water through flocculation, the product can be used as a feed; microfiltration and nanofiltration are adopted to remove various substances with molecular weight greater than 300 from water; amino acids are adsorbed by resins; and activated carbon is used to deodorizing so as to make the saline solution can be recycled and largely reduce the COD value of the sewage. Moreover, the method can process all sewage with the similar properties, has good investment prospects, operability and economical efficiency, and is an ideal choice for processing the present type of sewage.

The invention discloses a dried porcine soluble product and a production method thereof. The production method of the dried porcine soluble product comprises the following steps of heating an intestinal mucosa solution as a raw material for sterilization, and enabling protein to be flocculated; enabling the heated intestinal mucosa solution to stand in a specially made container to remove a supernatant, and performing concentration; crushing protein tissues, and performing an enzymolysis reaction; performing heating for enzyme denaturalixation, and extracting heparin sodium; performing negative pressure concentration; performing spray drying; and performing packaging. The dried porcine soluble product comprises the following components of water of which the content is 6.0-10.0wt%, crude protein of which the content is greater than or equal to 50.0wt%, crude fat of which the content is smaller than or equal to 3.0wt%, crude ash of which the content is smaller than or equal to 18.0wt%, table salt of which the content is smaller than or equal to 5.0wt%, free ammonia of which the content is smaller than or equal to 1.0wt%, and small peptide which is smaller than 2000 dalton and of which the content is greater than or equal to 10.0wt%, and protein hydrolysate which is greater than or equal to 45.0wt%. According to the dried porcine soluble product and the production method thereof disclosed by the invention, the free ammonia is removed by a standing method, so that the free ammonia in the dried porcine soluble can be effectively removed, besides, waste water cannot be produced, and the treatment cost is low; the supernatant after high-temperature sterilization is used as probiotics solid state fermentation nutrient fluid for soybean meal, so that pollution is not caused, and the sewage treatment cost is reduced.

The invention discloses a gastrointestinal pressure reducer with adjustable pressure. The gastrointestinal pressure reducer comprises an upper cover, a lower cover, a cylindrical barrel and a negativepressure suction spring, a sealed negative pressure suction cavity is formed among the upper cover, the lower cover and the cylindrical barrel; the gastrointestinal pressure reducer is characterizedin that a first ventilation seat and a second ventilation seat are arranged on the upper cover, ventilation holes are formed in the first ventilation seat and the second ventilation seat, the ventilation hole in the first ventilation seat is communicated with the gastrointestinal tract, and the ventilation hole in the second ventilation seat is connected with a pressure regulator used for regulating the maximum pressure in the negative pressure suction cavity. According to the gastrointestinal pressure reducer, the pressure in the negative pressure suction cavity can be limited within a set range, the negative pressure can be adjusted to be large to drain gastric contents of a patient, small negative pressure is adopted to drain intestinal contents of the patient, and the technical problems that intestinal mucosa damage and intestinal wall perforation are likely to be caused due to the fact that the same negative pressure is adopted in existing gastrointestinal drainage are solved.

The invention especially discloses a piglet creep feed without porcine homologous protein. The piglet creep feed without porcine homologous protein is prepared from the following ingredients in percentage by weight: 10-15% of wheat, 25-30% of puffed corn granules, 20-25% of oat, 1-3% of functional fiber, 1-3% of soybean oil, 10-13% of full-fat soybeans, 5-8% of Herring meal, 3-5% of concentrated whey protein, 5-8% of skimmed milk powder, 7-10% of whey, 0.1-0.2% of lysine hydrochloride, 0.1-0.2% of methionine, 0.5-1% of glucose, 0.6-1% of calcium hydrogen phosphate, 0.4-0.8% of limestone, 0.05-0.2% of table salt, 0.5-1.5% of multi-vitamin multi-mineral additive, 0.3-0.9% of acidulating agent, 0.1-0.2% of sweetener and 0.2-0.3% of zinc oxide. According to the invention, the Herring meal, the concentrated whey protein, the skimmed milk powder and the whey are rationally proportioned so as to replace plasma protein powder and intestinal mucosal protein; therefore, palatability as well as high digestibility and utilization rates are ensured for the piglet creep feed without porcine homologous protein, so that the piglets can be fed on feed instead of breast milk successfully. The piglet creep feed is capable of avoiding diarrhea and maintaining relatively good growth performances of the piglets.

The present invention relates to a composition for preventing or treating mucositis comprising NecroX. It was found that NecroX has effects of reducing the disease mortality rate by means of radiotherapy or chemotherapy in a NecroX administration group, protecting intestinal functions, inhibiting destruction of intestinal mucous membrane, and proliferating the cells present in intestines. NecroX may be used for a pharmaceutical composition for preventing or treating mucositis, an anti-cancer adjuvant, or a food composition.

The present invention relates to methods for improving the detection of pathologies in the colon and method of flagging the mucosal lesions in the colon.

The invention belongs to the technical field of biscuits, and particularly discloses a mulberry yogurt and carrot containing biscuit for promoting gastrointestinal health. The mulberry yogurt and carrot containing biscuit is prepared from the following raw materials: mulberry yogurt, carrot, fresh carrot tassel, flour, chestnut kernel, astragalus polysaccharide, camellia seed oil and pine pollen.The mulberry yogurt and carrot containing biscuit is unique in flavor, slightly sour and sweet and easy to digest and absorb, can effectively promote nutrition metabolism of a human body, degrade specific saccharides on epithelial cells of intestinal mucosae, prevent adhesion and invasion of pathogenic bacteria and toxins into the epithelial cells, inhibit breeding of gastrointestinal harmful bacteria, promote proliferation of beneficial bacteria, effectively promote absorption of vitamins and minerals, promote healthy and strong growth of bones of infants and young children, promote growth and development of immune organs, enhance immunity, improve disease resistance, promote metabolism of skin cells, effectively inhibit occurrence of a chapped skin phenomenon and make skin smooth and tender.

The invention discloses an application of araboxylan or a compound of the araboxylan and konjaku flour to preparation of foods, health care products or medicines for preventing / treating alcoholic gastrointestinal mucosa and liver injury. The araboxylan is prepared by pretreating plant raw materials to remove impurities and then performing alkali liquor extraction, dealkalization and purification. In the compound of the araboxylan and the konjaku flour, the mass ratio of the araboxylan accounts for 1-99%. The foods, the health care products or the medicines for preventing / treating the alcoholic gastrointestinal mucosa and liver injury are prepared from the araboxylan alone or the compound of the araboxylan and the konjaku flour, so that the injury of alcohol to the gastrointestinal mucosa and the liver can be effectively reduced.

The present invention refers to a composition for use in the prevention and / or treatment of orogastrointestinal mucositis induced by oncologic treatments. It also refers to the use of said composition for preparing a medicament for the prevention and / or treatment of said orogastrointestinal mucositis. Furthermore, it refers to a method of preventing and / or treating of said orogastrointestinal mucositis in which said composition is administered to a subject in need thereof.

The invention discloses a traditional Chinese medicinal jaundice-removal enema for treating icteric hepatitis. The traditional Chinese medicinal jaundice-removal enema is prepared from the following traditional Chinese medicinal raw materials: herba artemisiae scopariae, herba lysimachiae, herba centellae, rhizoma polygoni cuspidati, poria cocos, pericarpium arecae, stigma maydis, rhizoma atractylodis macrocephalae, radix et rhizoma rhei recens, polyporus, radix curcumae and fructus mume. The jaundice-removal enema provided by the invention has a unique curative effect on the treatment of theicteric hepatitis in a retention enema method and after being infused into a colon, a traditional Chinese medicine not only can locally exert the effects of facilitating bowel movement, expelling a toxin, promoting diuresis and descending turbidity, but also can be absorbed through a mucosa of the colon, enters a portal vein through a superior rectal vein and an inferior mesenteric vein, is not destroyed through gastric acid and a digestive enzyme, directly reaches a liver and enters a human body to circulate to exert the integral effects of clearing away heat, promoting diuresis and normalizing a gallbladder to remove jaundice.

This present invention relates to the use of eicosapentaenoic acid (EPA) for the treatment of ulcerative colitis (UC), and more particularly, the use of highly purified eicosapentaenoic acid as free fatty acids (EPA-FFA) having a purity of at least 95% for reducing inflammation in a subject suffering from ulcerative colitis and wherein the levels of IL-10 and SOCS3 are increased and the microbiome of the intestinal mucosal tissue is favorably modulated.