Fluorescent material, and preparation method and application thereof

A fluorescent material and hydrosilylation reaction technology, applied in the field of fluorescent materials, can solve the problems of destroying the fluorescent properties of mesoporous materials, photofading, environmental pollution, etc., and achieve good biocompatibility, strong resistance to photofading, and photostability Good results

Active Publication Date: 2014-03-26
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in these fluorescent materials, the luminescent groups introduced are generally organic molecules with π-bond conjugated structures, and organic molecules are prone to photofading, thereby destroying the fluorescent pr...

Method used

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  • Fluorescent material, and preparation method and application thereof
  • Fluorescent material, and preparation method and application thereof
  • Fluorescent material, and preparation method and application thereof

Examples

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preparation example Construction

[0024] The ordered mesoporous organosilicon material is commercially available or can be prepared. The preparation of the ordered mesoporous organic silicon material can be carried out according to conventional methods in the art, for example, the preparation method of the ordered mesoporous organic silicon material can include: polyoxyethylene-polyoxypropylene-polyoxyethylene ( P123) was dissolved in an aqueous solution of potassium chloride, then added hydrochloric acid solution and 1,2-bistrimethoxysilylethane (BTME) in sequence, then stirred and mixed at 10-60°C for 1-30 minutes and placed for 5- 50 hours, and then react in an autoclave at 80-120° C. for 5-50 hours. After the reaction, the solid product is collected, and the ordered mesoporous organic silicon material is separated from the solid product.

[0025] In the above method for preparing ordered mesoporous silicone material, the weight ratio of the amount of P123 to the amount of BTME can be 100:80-200, preferably...

preparation example 1

[0044] Preparation of PMO materials

[0045] At 40°C, 1 g of P123 (purchased from sigma-Aldrich) was dissolved in 2.98 g of 1.0 mol L -1 In the KCl aqueous solution, add 40g concentration to it again and be 0.167mol L -1 hydrochloric acid solution, and then 1.40 g of BTME (purchased from sigma-Aldrich) was added to the mixed solution and stirred. Stirring was stopped after 10 minutes, and the reaction system was left standing at 40° C. for 1 day. Subsequently, the mixture was transferred to an autoclave, and reacted at 100° C. for 24 hours. After the reaction, the solid product was collected by filtration and dried at room temperature. Finally, the solid product was subjected to Soxhlet extraction with ethanol to obtain the PMO material.

preparation example 2

[0047] Preparation of Modified Silicon Nanocrystals

[0048] At -75°C, mix 25ml of deionized water with 10ml of trichlorosilane, react for 1.5 hours to get a white precipitate, separate the white precipitate, and vacuum dry the white precipitate, then transfer it to a tube furnace, Burning at 1100° C. for 1 hour gave a brown complex. The compound was ground to a particle size below 1 mm, then 0.6 g of the ground compound was placed in a plastic beaker, 9 ml of deionized water, 18 ml of ethanol and 30 ml of hydrofluoric acid (48% by weight) were added thereto. After reacting for 3 hours, silicon nanocrystals with a particle size of about 3 nanometers were obtained, and then the silicon nanocrystals were extracted with n-decane to obtain a n-decane solution of silicon nanocrystals.

[0049] The n-decane solution of the silicon nanocrystals was transferred into a round bottom flask, and 9ml of vinyltriethoxysilane was added thereto; then frozen at -75°C, then decompressed and pu...

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Abstract

The invention provides a fluorescent material which contains an ordered mesoporous material and a modified silicon nanocrystal. The modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on a silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3. The invention also provides a preparation method of the fluorescent material, which comprises the following step: in the presence of an organic solvent, mixing and contacting the modified silicon nanocrystal and the ordered mesoporous material, wherein the modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on the silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3. The invention also provides application of the fluorescent material as a drug conduction carrier. The fluorescent material has fluorescent characteristic, and has the advantages of high capacity for resisting photofading and better drug slow-release property.

Description

technical field [0001] The invention relates to a fluorescent material, a preparation method of the fluorescent material, and an application of the fluorescent material as a drug conduction carrier. Background technique [0002] Mesoporous materials are regarded as very useful materials in the eyes of many scientists, they can be developed into organic-inorganic composite materials, and these composite materials have unique catalytic, sensing, optical, magnetic or electrical properties, and at the same time, functional groups Simplified mesoporous materials also play a very important role in the materials science community. Since the advent of the mesoporous material MCM41, people have been using various methods to synthesize organic composite mesoporous materials. In recent years, bridged silsesquioxane (R’O) 3 SiRSi(OR') 3 Materials synthesized by self-assembly have emerged as a new class of organic mesoporous materials, commonly referred to as ordered mesoporous organo...

Claims

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Application Information

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IPC IPC(8): C09K11/59A61K47/24
Inventor 关敏毕海鹏王足远卜少华黄铃杨力
Owner CHINA PETROLEUM & CHEM CORP
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