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Preparation method of high-yield core-shell drug-loading PAN nanofiber

A core-shell structure, nanofiber technology, applied in fiber processing, pharmaceutical formulations, fiber chemical characteristics, etc., can solve the problems of safe use, agglomeration, influence on emulsion stability, and fiber yield reduction, etc. The effect of good sustained release performance and high fiber yield

Active Publication Date: 2017-01-11
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the patent with publication number CN101509154A discloses a method for preparing drug nanofibers with shell-core structure by emulsion electrospinning technology; The method for preparing drug-loaded nanofibers with a core-shell structure from silk, emulsifiers are added during the preparation of the emulsion, and these emulsifiers generally have problems such as biological toxicity, safety in use, and agglomeration
The agglomeration of emulsifiers will affect the stability of the emulsion and reduce the fiber yield.
So far, there has been no report on the large-scale preparation of high-yield drug-loaded fibers with core-shell structure

Method used

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  • Preparation method of high-yield core-shell drug-loading PAN nanofiber
  • Preparation method of high-yield core-shell drug-loading PAN nanofiber
  • Preparation method of high-yield core-shell drug-loading PAN nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Take oxytetracycline hydrochloride 0.15g and dissolve in 5mL deionized water with an electronic balance, stir and dissolve to obtain a uniform drug aqueous solution;

[0041] (2) Weigh 8 g of polyacrylonitrile (PAN) with a viscosity-average molecular weight of 70,000 KDa and place it in a conical flask, stir and dissolve with 100 mL of DMF to obtain a uniform polymer solution;

[0042] (3) Add the uniform drug aqueous solution dropwise into the homogeneous polyacrylonitrile polymer solution under stirring state, and stop stirring after stirring at room temperature for 10 hours to form a spinning solution, which is a uniform, stable and transparent solution;

[0043] (4) Electrospinning the spinning solution using a NSLAB 500 nanospider electrospinning machine to prepare gel fibers;

[0044]The steps and process conditions of electrospinning are: firstly, the spinning solution is added to the liquid storage tank, the linear electrode is used as the spinning electrode...

Embodiment 2

[0048] (1) Take tetracycline hydrochloride 0.2g and dissolve in 5mL deionized water with an electronic balance, stir and dissolve to obtain a uniform drug aqueous solution;

[0049] (2) Weigh 9 g of polyacrylonitrile (PAN) with a viscosity-average molecular weight of 80,000 KDa and place it in a conical flask, stir and dissolve with 100 mL of DMF to obtain a uniform polymer solution;

[0050] (3) Add the uniform drug aqueous solution dropwise into the polyacrylonitrile polymer homogeneous solution under stirring state, and stop stirring after stirring at room temperature for 12 hours to form a spinning solution, which is a uniform, stable and transparent solution;

[0051] (4) Electrospinning the spinning solution using a NSLAB 500 nanospider electrospinning machine to prepare gel fibers; the steps and process conditions of the electrospinning are: first, the spinning solution is added to the liquid storage tank, and the linear The electrode was used as the spinning electrode,...

Embodiment 3

[0055] (1) Take 0.3 g of doxycycline hydrochloride with an electronic balance and dissolve it in 5 mL of deionized water, stir and dissolve to obtain a uniform drug aqueous solution;

[0056] (2) Weigh 8 g of polyacrylonitrile (PAN) with a viscosity-average molecular weight of 90,000 Kda and place it in a conical flask, stir and dissolve with 95 mL of DMF to obtain a uniform polymer solution;

[0057] (3) Add the uniform drug aqueous solution dropwise into the polyacrylonitrile polymer homogeneous solution under stirring state, and stop stirring after stirring at room temperature for 16 hours to form a spinning solution, which is a uniform, stable and transparent solution;

[0058] (4) Electrospinning the spinning solution using a NSLAB 500 nanospider electrospinning machine to prepare gel fibers;

[0059] The steps and process conditions of electrospinning are: firstly, the spinning solution is added to the liquid storage tank, the linear electrode is used as the spinning ele...

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Abstract

The invention discloses a preparation method of high-yield core-shell drug-loading PAN nanofiber; a simple solution system is utilized to prepare gel fiber by electrostatic spinning through nanospider electrostatic spinning machine, and the gel fiber is vacuum-dried to obtain the core-shell drug-loading PAN nanofiber having a diameter range of 100-800 nm. The spinning system prepared herein is stable, the preparation process is simple, there is no need to add an emulsifying agent, the cost is low, and energy consumption is low; the fiber prepared by using the method has high yield, and 0.5-1 g of the fiber may be prepared per min. The core-shell PAN nanofiber has effective slow release of drug and has potential application prospect in the field of slow release of drug.

Description

technical field [0001] The invention belongs to the field of preparation of drug-loaded nanofibers with a core-shell structure, and in particular relates to a method for preparing high-yield drug-loaded PAN nanofibers with a core-shell structure. Background technique [0002] Nanofibers prepared by electrospinning are good drug-loading materials. The traditional preparation method of electrospinning drug-loaded fibers is to mix drugs and carrier polymers in the same solvent, and use uniaxial electrospinning equipment to electrospin drug-loaded fibers. This method has strict requirements on the solvent, which limits the scope of application; and the obtained fiber is a common one-dimensional structure, which usually results in the drug being only distributed on the surface of the fiber and causing burst release. [0003] Now it is commonly used to prepare electrospun fibers into a double-layer (core / shell) structure by using coaxial electrospinning technology and emulsion el...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/54D01F1/10D01D5/00D01D5/30A61K9/70A61K47/32A61K31/65A61K31/704A61K31/51
CPCA61K9/0002A61K9/70A61K31/51A61K31/65A61K31/704A61K47/32D01D5/003D01D5/0092D01D5/30D01F1/10D01F6/54
Inventor 张平平李微梅贞王子方王延风路文娟吴忠玉孙捷杨晓霞
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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