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Curcumin nano crystal self-stabilizing Pickering emulsion and preparation method thereof

A technology of Pickering emulsion and curcumin, which is applied in anti-inflammatory agents, anti-toxic agents, pharmaceutical formulas, etc., can solve problems such as curcumin nanocrystal self-stabilizing Pickering emulsion reports, etc., to avoid toxic side effects, stabilize good sex effect

Inactive Publication Date: 2017-07-04
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] After consulting patents and literature, there is no relevant report on curcumin nanocrystalline self-stabilizing Pickering emulsion

Method used

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  • Curcumin nano crystal self-stabilizing Pickering emulsion and preparation method thereof
  • Curcumin nano crystal self-stabilizing Pickering emulsion and preparation method thereof
  • Curcumin nano crystal self-stabilizing Pickering emulsion and preparation method thereof

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Embodiment

[0026] 1. Preparation of curcumin nanocrystal suspension

[0027] Precisely weigh 30 mg of curcumin crude drug in a 10 mL centrifuge tube, and prepare primary curcumin nanocrystal suspension using a high-speed shearing machine with a shear speed of 25000 rpm. The primary curcumin nanocrystal suspension is added into a high-pressure homogenizer to prepare a curcumin nanocrystal suspension, and the high-pressure homogenization condition is 1000bar to obtain a curcumin nanocrystal suspension, and the curcumin nanocrystal average particle size is measured as 310.2±61.94nm.

[0028] 2. Preparation of Curcumin Nanocrystalline Self-stabilizing Pickering Emulsion

[0029] Add 0.5 g of glyceryl monocaprylate to the prepared curcumin nanocrystal suspension, and use a homogenizer to homogenize for 2 minutes at 25,000 rpm to prepare curcumin nanocrystal self-stabilizing Pickering colostrum, and then use a high-pressure homogenization mechanism Prepare curcumin nanocrystal self-stabilizi...

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Abstract

The invention discloses a curcumin nano crystal self-stabilizing Pickering emulsion and a preparation method thereof. Raw materials for preparing the curcumin nano self-stabilizing Pickering emulsion comprise the following components by percentage: 0.1-5% of curcumin, 5-10% of an oil phase, and the balance water, wherein the total amount of all the components is 100%. The preparation method comprises the steps: adding distilled water to the curcumin raw material medicine, carrying out shear dispersion by using a homogenizer to obtain a primary curcumin nano crystal suspension, and then preparing a curcumin nano crystal suspension by a high pressure homogenizer; and adding the oil phase to the curcumin nano crystal suspension, homogenating to obtain a curcumin nano crystal self-stabilizing Pickering primary emulsion, and then adding the primary emulsion into the high pressure homogenizer, to prepare the curcumin nano crystal self-stabilizing Pickering primary emulsion. The curcumin nano crystal as a stabilizer replaces traditional surfactants, the safety of the emulsion is improved, the stability is good, and slow release of curcumin can be kept for a long time while the emulsion drug loading capacity is increased.

Description

[0001] 【Technical field】 [0002] The invention belongs to the field of pharmaceutical preparations, in particular to a curcumin nanocrystal self-stabilizing Pickering emulsion and a preparation method thereof [0003] 【Background technique】 [0004] Pickering emulsion is an emulsion prepared by using solid particles instead of surfactants as emulsifiers. It was first discovered by Walter Ramsden in 1903, and S.U. Pickering further described the phenomenon in 1907. Later, this type of emulsion stabilized by solid particles was called Pickering emulsion. The solid particles used in Pickering emulsion are mainly SiO 2 , montmorillonite, and nanopolymer particles. The solid particles are closely arranged together, which acts as a steric hindrance, thereby inhibiting the aggregation of dispersed droplets and enhancing the stability of the emulsion. [0005] Curcumin is a diketone compound extracted from the rhizomes of turmeric, araceae, calamus, and turmeric. It has the effects...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/12A61K47/10A61P3/06A61P35/00A61P29/00A61P1/16A61P39/06
CPCA61K9/107A61K31/12A61K47/10
Inventor 张良珂冉娅
Owner CHONGQING MEDICAL UNIVERSITY
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