Anti-cancer drug-loading nanofiber film and preparation method thereof

Abstract

The invention relates to an anti-cancer drug-loading nanofiber film and a preparation method thereof. The nanofiber film is composed of a loading drug and a substrate, wherein a photosensitizer and a chemotherapeutic drug in a molar ratio of 1:(1-2) are used as the loading drug of the nanofiber film; a biodegradable high molecular material is used as the substrate of the nanofiber film; and the total drug mass is 4% of the substrate mass. The preparation method comprises the steps of: (1) adding the chemotherapeutic drug to glacial acetic acid, heating to dissolve the drug to obtain a chemotherapeutic drug solution; adding the photosensitizer and the biodegradable high molecular material into an organic solvent, uniformly stirring, and then adding the chemotherapeutic drug solution to prepare a high polymer solution; and (2) carrying out electrostatic spinning on the high polymer solution, and volatilizing the organic solvent and the glacial acetic acid to obtain the anti-cancer drug-loading nanofiber film. The anti-cancer drug-loading nanofiber film can be used as a wound dressing at an operation wound for preventing infection, stopping bleeding and promoting healing of the operation wound; and the preparation method has the advantages of simplicity in operation, low cost, good drug slow-release performance and broad application prospect.

Description

technical field [0001] The invention belongs to the field of composite nanofiber and its preparation, in particular to a nanofiber membrane loaded with anticancer drugs and its preparation method. Background technique [0002] Tumor is a common and frequently-occurring disease that seriously threatens human life. According to WHO statistics, among the 6 billion people in the world, an average of 6.9 million people die from malignant tumors each year, and 8.7 million new cases are diagnosed, and the number is still increasing year by year. At present, there are 1.8 million cancer patients in my country, and the mortality rate is the second among all causes. Therefore, governments, research institutes and pharmaceutical companies all over the world have been giving great importance and support to the research on tumor therapeutic drugs and methods. At present, the commonly used methods for clinical treatment of tumors include chemotherapy, radiotherapy and surgical resection...

AI Technical Summary

Problems solved by technology

[0004] 1. The cost of repeated surgery is high and the harm to the patient is great

Because cancer patients are in a state of physical and mental exhaustion after surgery, re-operation in a short period of time will bring great trauma and pain to the patient's body and mind, and the cost of repeated operations is high, which is a heavy economic burden on the patient's family and the country.

[0005] 2. Clinicians apply anti-tumor drugs on the tumor site after surgery to eliminate residual tumor cells. This method is extremely extensive and cannot be accurately dosed.

Most antineoplastic drugs have a relatively large killing effect on normal cells, so the choice of drug dosage is extremely important, otherwise the drug concentration will cause patient poisoning if the drug concentration is too large, and it will be ineffective if it is too small; Sustained release, the sudden release of the drug may cause poisoning of the patient, or the effective time of the drug is very short, and the drug concentration is far lower than its effective concentration when the tumor recurs