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Fluorescent material, and preparation method and application thereof

A technology of fluorescent materials and mesoporous materials, applied in the field of fluorescent materials, can solve the problems of destroying the fluorescence properties of mesoporous materials, poor chemical corrosion resistance, photofading, etc., and achieve good biocompatibility, strong resistance to photofading, The effect of good biocompatibility

Active Publication Date: 2014-03-26
CHINA PETROLEUM & CHEM CORP +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in these fluorescent materials, the luminescent groups introduced are generally organic molecules with π-bond conjugated structures, and organic molecules are prone to photofading, thereby destroying the fluorescent properties of mesoporous materials; moreover, because fluorescent organic molecules It is generally toxic and will cause environmental pollution during the synthesis process, and it is difficult to be widely used in fields such as biology; in addition, the introduced organic molecules containing π-bonded conjugated structures have certain chemical reactivity and are resistant to Poor chemical corrosion performance

Method used

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  • Fluorescent material, and preparation method and application thereof
  • Fluorescent material, and preparation method and application thereof
  • Fluorescent material, and preparation method and application thereof

Examples

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preparation example Construction

[0025] In one embodiment, the preparation method of ncSi may include: in the presence of an organic solvent, mixing silicon nanocrystals with the silane compound, cooling to -50°C to -100°C for freezing and degassing, and then raising the temperature to 150 -200°C, and react at this temperature for 8-16 hours (such as overnight reaction), and then carry out vacuum distillation to remove the unreacted silane compound and the organic solvent, thereby obtaining ncSi. The organic solvent is a solvent capable of dissolving the silicon nanocrystals, such as n-decane, ethanol, chloroform and the like.

[0026] The silicon nanocrystals can be obtained commercially, and can also be prepared according to conventional methods. For example, the preparation method can include: contacting and reacting trichlorosilane with excess deionized water at 0-78°C for 1-2 hours, and then filtering And collect the precipitate, burn the precipitate (such as burning at 800-1500°C for 0.5-3 hours), grind...

preparation example

[0039] Preparation of Modified Silicon Nanocrystals

[0040] At -75°C, mix 25ml of deionized water with 10ml of trichlorosilane, react for 1.5 hours to get a white precipitate, separate the white precipitate, and vacuum dry the white precipitate, then transfer it to a tube furnace, Burning at 1100° C. for 1 hour gave a brown complex. The compound was ground to a particle size below 1 mm, then 0.6 g of the ground compound was placed in a plastic beaker, 9 ml of deionized water, 18 ml of ethanol and 30 ml of hydrofluoric acid (48% by weight) were added thereto. After reacting for 3 hours, silicon nanocrystals with a particle size of about 3 nanometers were obtained, and then the silicon nanocrystals were extracted with n-decane to obtain a n-decane solution of silicon nanocrystals.

[0041] The n-decane solution of the silicon nanocrystals was transferred into a round bottom flask, and 9ml of vinyltriethoxysilane was added thereto; then frozen at -75°C, then decompressed and pu...

Embodiment 1

[0043] This example is used to illustrate the fluorescent material and its preparation method of the present invention.

[0044] Dissolve 1.025 g of the modified silicon nanocrystal prepared in the above preparation example in 8.074 g of ethanol, stir to fully dissolve the modified silicon nanocrystal, take 0.36 g of the obtained solution, and then add 50 mg of mesoporous Material SBA-15 (purchased from Jilin University High-tech Co., Ltd.), uniformly dispersed under stirring, and then added 0.1mol L -1 HCl in ethanol, adjust the pH to 1.5, and stir the reaction at 25 °C for 24 hr. After the reaction, the solid product was collected by centrifugation, washed with ethanol, and finally vacuum-dried to obtain fluorescent material A1.

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Abstract

The invention provides a fluorescent material which contains a mesoporous material and a modified silicon nanocrystal. The modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on a silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3, wherein R1 is an alkenyl group, and R2 is a substituted or unsubstituted alkyl group. The invention also provides a preparation method of the fluorescent material, which comprises the following step: in the presence of an organic solvent, mixing and contacting the modified silicon nanocrystal and the mesoporous material, wherein the modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on the silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3, wherein R1 is an alkenyl group, and R2 is a substituted or unsubstituted alkyl group. The invention also provides application of the fluorescent material as a drug conduction carrier. The fluorescent material has fluorescent characteristic, and has the advantages of high capacity for resisting photofading and better drug slow-release property.

Description

technical field [0001] The invention relates to a fluorescent material, a preparation method of the fluorescent material, and an application of the fluorescent material as a drug conduction carrier. Background technique [0002] In recent years, material science has developed rapidly. As an important branch of material science, mesoporous materials have many characteristics, such as large pore size and specific surface area, good thermal and mechanical stability, etc. , has aroused extensive attention of scientists. With the development of mesoporous materials, the application fields of mesoporous materials have gradually expanded, from the initial fields of adsorption, separation, and catalysis, and now they have expanded to many different fields, such as sensing technology and drug delivery systems, etc. As a specific example of silicon-based mesoporous materials, the mesoporous material SBA-15 not only has highly ordered mesoporous channels, thick inorganic pore walls, a...

Claims

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Application Information

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IPC IPC(8): C09K11/59A61K47/04
Inventor 毕海鹏关敏李传清于国柱李建成刘天鹤
Owner CHINA PETROLEUM & CHEM CORP
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