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Gold shell coated hollow mesoporous silicon dioxide spheres, method for preparing same and application thereof in tumor treatment

A technology of mesoporous silica and silica spheres, applied in the field of nanomaterials

Inactive Publication Date: 2010-06-09
张阳德 中国科学院理化技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although preliminary progress has been made in the exploration of the mechanism of thermochemotherapy, in the application of malignant tumor treatment, nanomaterials that can integrate photothermal conversion hyperthermia, chemotherapeutic drug loading and sustained release, in vivo imaging and targeted therapy have not yet been seen. to report

Method used

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  • Gold shell coated hollow mesoporous silicon dioxide spheres, method for preparing same and application thereof in tumor treatment
  • Gold shell coated hollow mesoporous silicon dioxide spheres, method for preparing same and application thereof in tumor treatment
  • Gold shell coated hollow mesoporous silicon dioxide spheres, method for preparing same and application thereof in tumor treatment

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Experimental program
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Effect test

Embodiment 1

[0050] (1) in 10 -8 mol / L of HAuCl 4 Add formaldehyde to the aqueous solution, stir and disperse to obtain a colloidal gold solution; wherein the concentration of formaldehyde in the colloidal gold solution is 10 -8 mol / L. Add hollow silica submicron spheres with a particle size of 260nm to the prepared colloidal gold solution, the sphere has a mesoporous structure, the average pore diameter of the mesopores is 10nm, and the specific surface area of ​​the sphere is 680m 2 / g, there is a movable spherical silica inner core with a particle size of 50nm in the hollow cavity of the silica submicron sphere, and the shell thickness of the movable silica submicron sphere is 20nm, and the hollow diatom in the solution The concentration of silica submicron spheres is 10 -1 mg / ml, the gold-adsorbed hollow mesoporous silica spheres with an inner core were obtained after the reaction. Afterwards, at a concentration of 10 -4 mol / L potassium carbonate solution, add HAuCl 4 , HAuCl in ...

Embodiment 2

[0055] (1) in 10 -3 mol / L of HAuCl 4 In the aqueous solution, add dimethylamine borane, stir and disperse to obtain a colloidal gold solution; wherein the concentration of dimethylamine borane in the colloidal gold solution is 10 -3 mol / L. Add hollow silica submicron spheres with a particle size of 40nm to the prepared colloidal gold solution, the sphere has a mesoporous structure, the average pore diameter of the mesopores is 7nm, and the specific surface area of ​​the sphere is 520m 2 / g, the shell thickness of the hollow silica submicron sphere is 10nm, there is no movable spherical silica core in the hollow cavity of the silica submicron sphere, and the concentration of the hollow silica submicron sphere in the solution is 10 2 mg / ml, the gold-adsorbed hollow mesoporous silica submicron spheres were obtained after the reaction. After that, in the potassium carbonate solution with a concentration of 0.1mol / L, add HAuCl 4 , HAuCl in solution 4 The concentration is 10 ...

Embodiment 3

[0058] (1) in 2×10 -5 mol / L of HAuCl 4 Add methanol to the aqueous solution, stir and disperse to obtain a colloidal gold solution; wherein the concentration of methanol in the colloidal gold solution is 5×10 -5 mol / L. Add hollow silica submicron spheres with a particle size of 800nm ​​to the prepared colloidal gold solution, the sphere has a mesoporous structure, the average pore diameter of the mesopores is 3nm, and the specific surface area of ​​the sphere is 140m 2 / g, there is a movable spherical silica core with a particle size of 600nm in the hollow cavity of the silica submicron sphere, and the shell thickness of the movable silica submicron sphere is 50nm, and the hollow dihydrogen The concentration of the silicon oxide submicron spheres is 100 mg / ml, and the gold-adsorbed hollow mesoporous silica spheres with inner cores are obtained after the reaction. Afterwards, at a concentration of 6×10 -7 mol / L potassium carbonate solution, add HAuCl 4 , HAuCl in solution ...

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Abstract

The invention relates to a gold shell coated hollow mesoporous silicon dioxide spheres, a method for preparing the same and application thereof in tumor treatment. In the gold shell coated hollow mesoporous silicon dioxide spheres, the hollow mesoporous silicon dioxide spheres or hollow mesoporous silicon dioxide spheres containing one kernel are used as cores, and the surfaces of the spheres are evenly coated with the gold shells; and the hollow mesoporous silicon dioxide spheres are filled with tumor resisting medicaments, and the surfaces of the gold shells are further coupled with specific targeting molecules of the tumor. The size of the hollow mesoporous silicon dioxide spheres and the thickness of the gold shell are controllable. According to the Mie scattering theory, the gold shells coated hollow mesoporous silicon dioxide spheres can adjust the absorption in the near infrared region and convert the light energy of the near infrared laser into the heat energy nearby to kill tumor cells. The hollow mesoporous silicon dioxide spheres can be used as controlled release carriers of therapeutic medicaments, and simultaneously the tumor specificity targeting molecules coupled on the surfaces of the gold shells make the preparation have the targeting function. The material is the multifunctional tumor resisting nanometer preparation integrating photothermal therapy, chemical therapy, high targeting and controlled release.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a hollow mesoporous silica sphere coated with a gold shell with high targeting and sustained and controlled release, a preparation method thereof and an application in tumor treatment. Background technique [0002] Malignant tumor is one of the main fatal diseases of human beings. With the improvement of industrialization and the deterioration of the surrounding environment, the number of malignant tumor patients in the world is showing a rising trend. Over the past two decades, governments around the world have been increasing research expenses on malignant tumors. The total medical expenditure of cancer patients has led to a huge loss of economic resources. Experts estimate that it is 14 billion per year. However, the treatment effect of malignant tumors is very low. Unsatisfactory, conquering cancer has become the common aspiration of governments and pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/02A61P35/00
CPCA61K9/0019A61K47/48561A61K47/48584A61K31/7076C01B33/12A61K9/5115A61K31/337A61K41/0052A61K47/6849A61K47/6855A61P35/00
Inventor 陈东唐芳琼刘惠玉李琳琳孟宪伟张阳德张宗久
Owner 张阳德 中国科学院理化技术研究所
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