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Calcium silicate multi-level nano-structure mesoporous microsphere and preparation method thereof

A nanostructure, calcium silicate technology, applied in the direction of silicate, alkaline earth metal silicate, inorganic non-effective ingredients, etc., to achieve the effect of cheap raw materials, simple preparation process, uniform shape and size

Active Publication Date: 2010-03-17
中科西卡思(苏州)科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of most materials by ultrasonic method still requires the assistance of various surfactants.
The preparation of calcium silicate hierarchical nanostructured mesoporous microspheres without surfactant has not been reported yet

Method used

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  • Calcium silicate multi-level nano-structure mesoporous microsphere and preparation method thereof
  • Calcium silicate multi-level nano-structure mesoporous microsphere and preparation method thereof
  • Calcium silicate multi-level nano-structure mesoporous microsphere and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035] Preparation of Calcium Silicate Hierarchical Nanostructured Mesoporous Microspheres

[0036] Prepare NaOH aqueous solution with a concentration of 1mol / L and Ca(NO 3 ) 2 aqueous solution. At room temperature, under the condition of stirring, to 65mL concentration of 0.046mol / L Ca(NO 3 ) 2 Add 5 mL of 1 mol / L NaOH aqueous solution and 0.34 mL of ethyl silicate in sequence to the aqueous solution to obtain an emulsion. Then the ultrasonic probe was immersed in the emulsion, and the ultrasound was applied for 20 minutes under the power of 400W. After the reaction, the product was separated by centrifugation, and the separated product was washed three times with deionized water and ethanol, and dried in an air atmosphere at 60° C. to obtain calcium silicate multi-level nanostructured mesoporous microspheres.

Embodiment 2

[0038] Preparation of Calcium Silicate Hierarchical Nanostructured Mesoporous Microspheres

[0039] Prepare NaOH aqueous solution with a concentration of 1mol / L and Ca(NO 3 ) 2 aqueous solution. At room temperature, under the condition of stirring, to 65mL concentration of 0.046mol / L Ca(NO 3 ) 2 Add 10 mL of 1 mol / L NaOH aqueous solution and 0.34 mL of ethyl silicate in sequence to the aqueous solution to obtain an emulsion. Then the ultrasonic probe was immersed in the emulsion, and the ultrasound was applied for 20 minutes under the power of 400W. After the reaction, the product was separated by centrifugation, and the separated product was washed three times with deionized water and ethanol, and dried in an air atmosphere at 60° C. to obtain calcium silicate multi-level nanostructured mesoporous microspheres.

Embodiment 3

[0041] Preparation of Calcium Silicate Hierarchical Nanostructured Mesoporous Microspheres

[0042] Prepare NaOH aqueous solution with a concentration of 1mol / L and Ca(NO 3 ) 2 aqueous solution. At room temperature, under the condition of stirring, to 65mL concentration of 0.046mol / L Ca(NO 3 ) 2 Add 3 mL of 1 mol / L NaOH aqueous solution and 0.34 mL of ethyl silicate in sequence to the aqueous solution to obtain an emulsion. Then the ultrasonic probe was immersed in the emulsion, and the ultrasound was applied for 20 minutes under the power of 400W. After the reaction, the product was separated by centrifugation, and the separated product was washed three times with deionized water and ethanol, and dried in an air atmosphere at 60° C. to obtain calcium silicate multi-level nanostructured mesoporous microspheres.

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Abstract

The invention relates to a calcium silicate multi-level nano-structure mesoporous microsphere and a preparation method thereof, and belongs to the field of biomaterials. The method provided by the invention comprises the steps of mixing Ca(NO3)2 water solution and NaOH water solution uniformly in a stirring condition, then adding ethyl orthosilicate to react under ultrasonication, and then centrifugally separating, washing by water and alcohol and at last drying to obtain the product. The mole ratio of calcium to silicon of the calcium silicate multi-level nano-structure mesoporous microsphereis 3:2. The particle size of cellular spherical-like particles packaged by nano-plates is 0.6-1.5 mu m and the cellular spherical-like particles are in a mesoporous structure, and the bore diameter distribution of the mesopore ranges from 4 to 30nm. The invention has the advantages of large specific surface area, large pore space, high drug-loading rate and excellent medicine slow release property for medicines insoluble in water, and wide application prospects in the field of biomedicine.

Description

technical field [0001] The invention relates to a calcium silicate multilevel nanostructured mesoporous microsphere and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] Mesoporous microspheres are porous micron-scale spherical particles with a pore diameter between 2-50 nm. Due to its large specific surface area, mesoporous materials are widely used in catalysis and other fields, and have good application potential in separation and purification, new assembly materials and biological materials. [0003] In the past decade, the application of silicon-based mesoporous materials in drug delivery systems has received extensive attention. Silicon-based mesoporous materials not only have large specific surface area and pore volume, but also have good biocompatibility. The silicon-based mesoporous materials currently used in the research of drug delivery carriers are mainly hollow spheres, core-shell structures, porous pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/24A61K47/02
Inventor 朱英杰吴进
Owner 中科西卡思(苏州)科技发展有限公司
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