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Preparation method and application of Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere

A technology of composite microspheres and eggshells, applied in the field of biomedical materials, can solve the problems of affecting the bearing capacity, unfavorable magnetic particle distribution, changing the surface properties of particles, etc., and achieves the effect of ensuring high dispersibility and good drug sustained release performance.

Inactive Publication Date: 2016-08-10
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, because the magnetic particles themselves are magnetic, they are easy to agglomerate, which is not conducive to the distribution of magnetic particles in the body.
Now, the common way to reduce agglomeration is to add surfactants, but this method not only changes the surface properties of the particles and affects their load-carrying capacity, but also reduces the biocompatibility due to the presence of surfactants

Method used

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  • Preparation method and application of Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere
  • Preparation method and application of Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere
  • Preparation method and application of Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere

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Embodiment 1

[0025] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 190°C for 3.5h, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol washed, washed with water, and then dried at 60°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Nanospheres were dispersed into 60vol% ethanol at a solid-to-liquid ratio of 1:250, added with ethanol solution of TEOS (tetraethyl orthosilicate), ultrasonically treated at 25°C for 3 hours, then ammonia water was added, stirred for 3 minutes, and reacted at room temperature for 2 hours. The obtained solid was washed with ethanol, then washed with water, and then dried at 60°C to obtain Fe 2 o 3 @SiO...

Embodiment 2

[0041] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 170°C for 3 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 55°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres in 90vol% ethanol according to the solid-to-liquid ratio of 1g:200ml, add TEOS (tetraethyl orthosilicate) ethanol solution, ultrasonically treat for 4h at 20°C, then add ammonia water, stir for 1min, and react at room temperature for 3h. The resulting solid was washed with ethanol, washed with water, and then dried at 65°C to obtain Fe 2 o 3 @SiO 2 Composite microspheres; ③...

Embodiment 3

[0046] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 200°C for 6 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 65°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres into 10vol% ethanol according to the solid-to-liquid ratio of 1g:350ml, add TEOS (tetraethyl orthosilicate) ethanol solution, ultrasonically treat at 30°C for 2 hours, then add ammonia water, stir for 5 minutes, and react at room temperature for 1 hour. The obtained solid was washed with ethanol, then washed with water, and then dried at 55°C to obtain Fe 2 o 3 @SiO 2 Compo...

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Abstract

The invention provides a preparation method and application of a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere. The preparation method comprises the following steps: preparing Fe2O3 nanoparticles by using a solvothermal method; under the condition that no surfactant is added and TEOS is used as a silicon source, preparing a Fe3O4@SiO2 composite microsphere with controllable morphology under mild conditions by using a combination of a template method and a hydrothermal method; corroding the Fe3O4@SiO2 composite microsphere with hydrochloric acid with a certain concentration so as to obtain a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere; and carrying out reduction so as to prepare the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere with superparamagnetism. The prepared Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a specific surface area of 173 m<2> / g and drug loading capacity of 139 mg / g; and with doxorubicin hydrochloride as a drug model, the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a drug release rate of as high as 68.4% within 72 h in a PBS buffer solution with a pH value of 7.4, so the composite microsphere presents good slow drug release performance.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a Fe 3 o 4 @SiO 2 Preparation method and application of hollow composite microspheres with egg yolk-eggshell structure. Background technique [0002] In recent years, with the continuous development of medical technology, drug sustained and controlled release preparations have gradually become the focus of pharmaceutical research, and the key to drug sustained and controlled release technology is the selection of drug carriers. So far, the widely used carrier materials include polymer carriers, intercalated polymer micelle carriers, dendrimers, liposome carriers and inorganic carriers. Inorganic nanomaterials, such as mesoporous materials, nanotubes, hollow microspheres, etc., are well-known for their good chemical stability, controllable particle shape and size, easy modification of surface and pores, and unique optical, magnetic, and electrical properties. It has gradual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/704A61K47/04A61P35/00C01G49/08B82Y30/00
CPCA61K9/5078A61K31/704A61K47/02B82Y30/00C01G49/08C01P2002/72C01P2002/82C01P2004/04C01P2004/64
Inventor 王永强程琳郑海红虞勇
Owner HENAN UNIVERSITY
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