A kind of monodisperse hollow Prussian blue nano microsphere, its preparation method and application

A nano-microsphere, Prussian blue technology, applied in the field of nano-materials, can solve the problems of uneven thermal distribution, tumor recurrence and metastasis, incomplete tumor thermal ablation, etc., to achieve good biological safety, ensure high dispersion, excellent light Effects of Thermal Conversion Efficiency and Photothermal Stability

Active Publication Date: 2020-07-31
新沂市棋盘工业集中区建设发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Studies have found that the uneven heat distribution generated by a single photothermal therapy may lead to incomplete thermal ablation of tumors, leading to related problems such as tumor recurrence and metastasis

Method used

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  • A kind of monodisperse hollow Prussian blue nano microsphere, its preparation method and application
  • A kind of monodisperse hollow Prussian blue nano microsphere, its preparation method and application
  • A kind of monodisperse hollow Prussian blue nano microsphere, its preparation method and application

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Effect test

Embodiment 1

[0051] A preparation method of monodisperse hollow Prussian blue nanospheres, comprising the following steps:

[0052] (1) Add 1 g FeCl 3 ·6H 2 O, 1 g of urea, and 3 g of sodium citrate were uniformly dissolved in 60 g of deionized water, and then 80 g of sodium polyacrylate (molecular weight was 20,000 to 2,000,000, gelatinous at room temperature) was added, stirred evenly, and then transferred to the reaction kettle. Hydrothermal reaction at 180 °C for 3 h, cooled to room temperature, and centrifuged to obtain an orange-yellow solid, which was washed with ethanol and deionized water successively, and then dried at 60 °C to obtain Fe 2 o 3 nanospheres;

[0053] (2) 10 mg of Fe prepared in step (1) 2 o 3 Nanospheres were dispersed into 45 mL of alcohol-water mixed solution (35 mL of ethanol, 10 mL of water), and then 0.1 mL of 0.1 M K 4 [Fe(CN) 6 ] solution, mechanically stirred at a speed of 200 r / min, and after being fully mixed, 5 mL of 6 M HCl was added dropwise usi...

Embodiment 2

[0090] A preparation method of monodisperse hollow Prussian blue nanospheres, comprising the following steps:

[0091] (1) Add 1 g FeCl 3 ·6H 2 O, 0.5 g of urea, and 2 g of trisodium citrate were uniformly dissolved in 60 g of deionized water, then 30 g of sodium polyacrylate was added, stirred evenly, and then transferred to a reactor for hydrothermal reaction at 170 °C for 3 h, cooled to Centrifuge at room temperature to obtain an orange-yellow solid, which is washed successively with ethanol and deionized water, and then dried at 55 °C to obtain Fe 2 o 3 nanospheres;

[0092] (2) 10 mg of Fe prepared in step (1) 2 o 3 Nanospheres were dispersed into 45 mL of alcohol-water mixed solution (35 mL of ethanol, 10 mL of water), and then 0.1 mL of 0.1 M K 4 [Fe(CN) 6 ] solution, mechanically stirred at a speed of 200 r / min, and after being fully mixed, 4 mL of 6 M HCl was added dropwise using a peristaltic pump, ultrasonically reacted at 25 °C for 3 h, centrifuged to obtain...

Embodiment 3

[0096] A preparation method of monodisperse hollow Prussian blue nanospheres, comprising the following steps:

[0097] (1) Add 1 g FeCl 3 ·6H 2 O, 0.25 g of urea, and 4 g of trisodium citrate were uniformly dissolved in 30 g of deionized water, then 40 g of sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 190°C for 3 h, and cooled to After room temperature, it was centrifuged to obtain an orange-yellow solid, which was washed with ethanol and deionized water successively, and then dried at 55 °C to obtain Fe 2 o 3 nanospheres;

[0098] (2) 10 mg of Fe prepared in step (1) 2 o 3 Nanospheres were dispersed into 45 mL of alcohol-water mixed solution (35 mL of ethanol, 10 mL of water), and then 0.2 mL of 0.1 M K 4 [Fe(CN) 6 ] solution, mechanically stirred at a speed of 200 r / min, and after being fully mixed, 5 mL of 8 M HCl was added dropwise using a peristaltic pump, ultrasonically reacted at 25 °C for 5 h, centrif...

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Abstract

The invention belongs to the technical field of nano-materials, and particularly relates to a mono-disperse hollow Prussian blue nano-sphere, a preparation method thereof and an application of the nano-sphere. The Fe2O3 nano-sphere is prepared by a solvothermal method, serves as a chemical template and is compounded with K4[Fe(CN)6], remained Fe2O3 is removed by acid to prepare the mono-disperse hollow Prussian blue nano-sphere (HPB NSs) which is uniform in appearance, and the shell layer thickness and the inner cavity size of the nano-sphere can be controlled. The preparation method is simple in process, convenient to operate and low in cost investment, and the prepared mono-disperse hollow Prussian blue nano-sphere is high in stability, biological safety, loading capacity and photo-thermal conversion efficiency and good in biocompatibility and has important application values in the field of drug carriers.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a monodisperse hollow Prussian blue nanometer microsphere, its preparation method and its application as a multifunctional drug carrier. Background technique [0002] In recent years, the rapid development of biotechnology and nanomedicine has brought a new revolution to tumor treatment. Among them, new drug carriers based on nanomaterials provide new ideas for tumor treatment. At present, nanomaterials for the preparation of new drug carriers mainly include liposomes, polymer materials, polymer micelles, and inorganic nanomaterials. These new drug carriers have excellent properties such as changing pharmacokinetics, increasing drug loading and drug utilization, realizing targeted delivery of drugs and on-demand drug delivery at the lesion site, and regulating drug release rates. The toxicity and side effects of the body are of great significance, and ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/704A61K47/02A61K41/00A61P35/00
CPCA61K9/501A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 王永强卢龙张传斌马明赵璐
Owner 新沂市棋盘工业集中区建设发展有限公司
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