Layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer and preparation method thereof

A layered silicate and nano-clay technology, which is applied in pharmaceutical formulations, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve the problems of multiple medications, difficulties, weakening the selective adsorption performance of molecularly imprinted polymers, etc. problem, to achieve the effect of simple preparation method and low cost

Active Publication Date: 2016-05-25
TIANJIN POLYTECHNIC UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The molecularly imprinted polymer prepared by the traditional embedding method has a three-dimensional structure and a high degree of cross-linking, which has many disadvantages: the molecularly imprinted polymer embeds the template molecule very deeply or very tightly, and the utilization of the imprinted site is not complete, so it is difficult to use The removal of the template molecule from the binding site causes incomplete elution of the template molecule; the number of imprinted sites is less than expected, and the selective adsorption of the molecularly imprinted polymer to the template molecule is poor; the prepared molecularly imprinted polymer needs to be pulverized Or grinding, the uneven shape and size of the obtained particles reduces the imprinting effect, and the material loss increases the cost of scientific re

Method used

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  • Layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer and preparation method thereof
  • Layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer and preparation method thereof
  • Layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prepare hectorite / sinomenine hydrochloride molecularly imprinted polymer according to the following steps

[0040] (1) Pretreatment of laponite; take 0.5g laponite and dissolve it in distilled water to make a hectorite aqueous solution with a mass fraction of 2wt.%, so that hectorite is fully swollen in the aqueous solution for 12h until it is stripped state, stand for use;

[0041] (2) Preparation of hectorite / sinomenine molecularly imprinted polymer: Weigh 1 mmol of sinomenine hydrochloride and dissolve it in 60 mL of N,N-dimethylformamide, then add 6 mmol of functional monomer methacrylic acid, 20 mmol of Co-agent ethylene glycol dimethacrylate, 2.0g sodium lauryl sulfate and 0.6mmol initiator azobisisobutyronitrile; Nitrogen 20min exhausted the oxygen in the reaction vessel, added dropwise step 1) after swelling Stir the hectorite aqueous solution at room temperature for 1 hour; then heat it with an oil bath, keep stirring and raise the temperature to 65°C, and con...

Embodiment 2

[0055] Prepare hectorite / sinomenine hydrochloride molecularly imprinted polymer according to the following steps

[0056] (1) Pretreatment of hectorite; take 0.25g hectorite and dissolve it in distilled water to make a hectorite aqueous solution with a mass fraction of 2wt.%, so that hectorite is fully swollen in the aqueous solution for 24h until it is stripped state, stand for use;

[0057] (2) Preparation of hectorite / sinomenine molecularly imprinted polymer: Weigh 1 mmol of sinomenine hydrochloride and dissolve it in 60 mL of N,N-dimethylformamide, then add 3 mmol of functional monomer methacrylic acid, 20 mmol of Joint agent ethylene glycol dimethacrylate, 2.0g sodium lauryl sulfate and 0.3mmol initiator azobisisobutyronitrile; Nitrogen gas 20min exhausts the oxygen in the reaction system, drops step 1) after swelling Stir the hectorite aqueous solution at room temperature for 1 hour; then heat with an oil bath, continue to stir and raise the temperature to 65°C, and con...

Embodiment 3

[0059] The hectorite / sinomenine hydrochloride molecularly imprinted polymer was prepared according to the following steps:

[0060] (1) Pretreatment of hectorite; take 0.1g hectorite and dissolve it in distilled water to make a hectorite aqueous solution with a mass fraction of 1.5wt.%, so that hectorite is fully swollen in the aqueous solution for 12h until it becomes Stripped state, stand for use;

[0061] (2) Preparation of hectorite / sinomenine molecularly imprinted polymer: Weigh 0.5mmol sinomenine hydrochloride and dissolve it in 60mL N,N-dimethylformamide, then add 6mmol functional monomer methacrylic acid, 20mmol Cross-linking agent ethylene glycol dimethacrylate, 2.0g sodium lauryl sulfate and 1mmol initiator azobisisobutyronitrile; Nitrogen gas 20min to remove the oxygen in the reaction system, drop step 1) after swelling Stir the hectorite aqueous solution at room temperature for 1 hour; then heat with an oil bath, continue to stir and raise the temperature to 65°C,...

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Abstract

The invention discloses a preparation method of a layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer, wherein the preparation method comprises the following steps: 1) preparing an aqueous solution/suspension by using layered silicate nanoclay, and allowing to stand for standby application; and 2) dissolving a traditional Chinese medicine active monomer into a solvent in a reaction vessel, and then adding a functional monomer, a crosslinking agent and an initiator; in an inert gas atmosphere, adding the aqueous solution/suspension obtained in the step 1) by a dropping way; stirring to be uniform at room temperature, heating up to 60-70 DEG C, and carrying out a constant-temperature reaction until the reaction is finished; carrying out suction filtration, collecting a solid, and repeatedly washing the solid with an eluent until the traditional Chinese medicine active monomer as template molecules is eluted; and then drying to constant weight, and thus obtaining the layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer. The preparation method is simple; and the obtained product can effectively improve the shortcomings of template molecules of a traditional method, effectively improves the drug loading capacity, and can be used as a novel drug carrier.

Description

technical field [0001] The invention belongs to the technical field of preparation of novel drug carriers and functional materials, and in particular relates to a layered silicate nano-clay / Chinese medicine active monomer molecularly imprinted polymer and a preparation method thereof. Background technique [0002] Molecular Imprinting Technology, Molecular Imprinting Technique, abbreviated as MIT, is an experimental preparation technology for obtaining a specific polymer. Because the spatial structure and binding sites of the obtained polymer can completely match the template molecules, molecular imprinting technology is also used by people. called molecular template technology. Immunology in biomedical science is the origin of the idea of ​​molecular imprinting technology, which initially began with people's understanding of antibody-antigen or enzyme specificity. Molecular imprinting technology has three characteristics, which are also its three advantages: wide practicab...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/06C08F2/44C08K9/00C08K3/34C08J9/26B01J20/26B01J20/30A61K47/32
Inventor 张华张雯付海丽张凤宋少波张喜悦刘珺
Owner TIANJIN POLYTECHNIC UNIV
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