Layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer and preparation method thereof

Abstract

The invention discloses a preparation method of a layered silicate nanoclay / traditional Chinese medicine active monomer molecularly imprinted polymer, wherein the preparation method comprises the following steps: 1) preparing an aqueous solution / suspension by using layered silicate nanoclay, and allowing to stand for standby application; and 2) dissolving a traditional Chinese medicine active monomer into a solvent in a reaction vessel, and then adding a functional monomer, a crosslinking agent and an initiator; in an inert gas atmosphere, adding the aqueous solution / suspension obtained in the step 1) by a dropping way; stirring to be uniform at room temperature, heating up to 60-70 DEG C, and carrying out a constant-temperature reaction until the reaction is finished; carrying out suction filtration, collecting a solid, and repeatedly washing the solid with an eluent until the traditional Chinese medicine active monomer as template molecules is eluted; and then drying to constant weight, and thus obtaining the layered silicate nanoclay / traditional Chinese medicine active monomer molecularly imprinted polymer. The preparation method is simple; and the obtained product can effectively improve the shortcomings of template molecules of a traditional method, effectively improves the drug loading capacity, and can be used as a novel drug carrier.

Description

technical field [0001] The invention belongs to the technical field of preparation of novel drug carriers and functional materials, and in particular relates to a layered silicate nano-clay / Chinese medicine active monomer molecularly imprinted polymer and a preparation method thereof. Background technique [0002] Molecular Imprinting Technology, Molecular Imprinting Technique, abbreviated as MIT, is an experimental preparation technology for obtaining a specific polymer. Because the spatial structure and binding sites of the obtained polymer can completely match the template molecules, molecular imprinting technology is also used by people. called molecular template technology. Immunology in biomedical science is the origin of the idea of ​​molecular imprinting technology, which initially began with people's understanding of antibody-antigen or enzyme specificity. Molecular imprinting technology has three characteristics, which are also its three advantages: wide practicab...

AI Technical Summary

Problems solved by technology

[0003] The molecularly imprinted polymer prepared by the traditional embedding method has a three-dimensional structure and a high degree of cross-linking, which has many disadvantages: the molecularly imprinted polymer embeds the template molecule very deeply or very tightly, and the utilization of the imprinted site is not complete, so it is difficult to use The removal of the template molecule from the binding site causes incomplete elution of the template molecule; the number of imprinted sites is less than expected, and the selective adsorption of the molecularly imprinted polymer to the template molecule is poor; the prepared molecularly imprinted polymer needs to be pulverized Or grinding, the uneven shape and size of the obtained particles reduces the imprinting effect, and the material loss increases the cost of scientific research; during the adsorption process of molecularly imprinted polymers, the mass transfer rate becomes very slow due to the deep imprinted pores, and the template molecules re-enter The process of imprinting holes is very difficult and impairs the selective adsorption properties of molecularly imprinted polymers

However, the bioavailability of conventional oral preparations is low, the half-life is short, and it needs to be taken repeatedly, which is inconvenient to use, and the peak-valley phenomenon of blood drug concentration caused by frequent medication affects the clinical curative effect

However, there is no report on the use of molecularly imprinted polymers as the carrier of sinomenine or its hydrochloride sustained-release preparations, and its use in drug delivery systems or the rapid separation and purification of sinomenine

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