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Composite-structure anti-inflammatory medicine-carrying fiber for transdermal drug delivery

A composite structure, anti-inflammatory drug technology, applied in the direction of anti-inflammatory agent, drug combination, fiber treatment, etc., can solve the problems of poor strength, pure bacterial cellulose is not suitable for drug-carrying system, and drugs are prone to burst release phenomenon, etc. Expand the scope of application and reduce the effect of secondary damage

Inactive Publication Date: 2016-11-09
YANCHENG INST OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The biocompatibility of bacterial cellulose is very good. If bacterial cellulose fiber is used for drug-loaded fiber, due to its hydrogel properties, not only the strength is poor under wet conditions, but the drug-loaded fiber in the drug-release solution system Drugs are very prone to burst release, which makes pure bacterial cellulose unsuitable for use as a good drug delivery system

Method used

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  • Composite-structure anti-inflammatory medicine-carrying fiber for transdermal drug delivery
  • Composite-structure anti-inflammatory medicine-carrying fiber for transdermal drug delivery
  • Composite-structure anti-inflammatory medicine-carrying fiber for transdermal drug delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An anti-inflammatory drug-loaded fiber with a composite structure for transdermal administration and its preparation method:

[0027] The first step: the preparation of bacterial cellulose fibers. With N,N-dimethylacetamide / lithium chloride (DMAc / LiCl), zinc chloride (ZnCl 2 ), ionic liquid, N-methylmorpholine aqueous solution (NMMO) any one of the solvents, the bacterial cellulose solid content of 1% (w / w) spinning solution prepared at room temperature, wet spinning, dry spinning Bacterial cellulose fibers were prepared by conventional spinning or dry-jet wet spinning.

[0028] The second step: drug-loading finishing of bacterial cellulose fibers. The drugs are anti-inflammatory drugs, including aspirin, paracetamol, indomethacin, naproxen, naproxen, diclofenac, ketoprofen, ibuprofen, nimesulide, rofecoxib , celecoxib, etc., or a combination thereof, anti-inflammatory drugs and transdermal enhancers (one of azone, oleic acid, N-methyl-2-pyrrolidone, propylene glycol...

Embodiment 2

[0032] In this example, the mass concentration of bacterial cellulose A spinning solution is 1.5%, the dissolved concentration of anti-inflammatory drug B is 60 g / L (w / w), and the dissolved concentration of transdermal enhancer C is 60 g / L (w / w). / w), polyacrylonitrile D is a dilute solution with a solution mass concentration of 1% (w / w), and the other methods are the same as in Example 1.

Embodiment 3

[0034] The mass concentration of bacterial cellulose A spinning solution was 2%, the dissolved concentration of anti-inflammatory drug B was 70 g / L (w / w), and the dissolved concentration of transdermal enhancer C was 70 g / L (w / w). Acrylonitrile D solution is a dilute solution with a mass concentration of 3% (w / w), and other methods are the same as in Example 1.

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Abstract

The invention discloses composite-structure bacterial cellulose / polyacrylonitrile medicine-carrying fiber prepared with an anti-inflammatory agent as the model medicine according to the characteristics of compactness and hydrophobicity of polyacrylonitrile. The composite medicine-carrying fiber is prepared from bacterial cellulose, polyacrylonitrile, anti-inflammatory agent and a medicine skin penetration enhancer through three steps. Compared with bacterial cellulose fiber, the bacterial cellulose / polyacrylonitrile composite medicine-carrying fiber has greatly improved mechanical performance, dry-strength larger than or equal to 3.0 cN / dtex, wet-strength larger than or equal to 2.0 cN / dtex, dry extensibility of 15% and wet extensibility of 25%, and overcomes the defect that bacterial cellulose is poor in wet-strength; the fiber has a skin-core structure prepared through polyacrylonitrile coating soaking treatment, and coarse surface appearance becomes smooth; the fiber has better medicine slow-release property, and the slow-release time can be controlled to be 1-10 days according to a composite process; the composite medicine-carrying fiber can be woven into a suture with anti-inflammatory and analgesic functions and can also be woven into fabric and used as external dressing with anti-inflammatory, anti-rheumatism, analgesic, anti-febrile and anti-coagulation functions.

Description

technical field [0001] The invention relates to an anti-inflammatory drug-loaded fiber with a composite structure for transdermal administration and a preparation method thereof, belonging to the technical field of material processing. Background technique [0002] Anti-inflammatory drugs are drugs used to treat inflammation in response to tissue damage. There are two types of anti-inflammatory drugs: one is steroidal anti-inflammatory drugs, that is, the glucocorticoid hydrocortisone secreted by the adrenal cortex and its synthetic derivatives. The other category is non-steroidal anti-inflammatory drugs (NSAIDs, non-steroid-anti-inflammatory drugs), that is, antipyretic, analgesic and anti-inflammatory drugs referred to in medical practice. Non-steroidal anti-inflammatory drugs are a class of anti-inflammatory drugs that do not contain a steroidal structure. They exert anti-inflammatory effects by inhibiting the synthesis of prostaglandins, inhibiting the aggregation of ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/32A61K45/00A61P29/00A61L17/10D06M15/31D01F2/24D06M101/06
CPCA61K9/0014A61K9/70A61K45/00A61K47/32A61K47/38A61L17/005A61L17/10D01F2/24D06M15/31D06M2101/06
Inventor 吴焕岭
Owner YANCHENG INST OF IND TECH
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