Composite-structure anti-inflammatory medicine-carrying fiber for transdermal drug delivery
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A composite structure, anti-inflammatory drug technology, applied in the direction of anti-inflammatory agent, drug combination, fiber treatment, etc., can solve the problems of poor strength, pure bacterial cellulose is not suitable for drug-carrying system, and drugs are prone to burst release phenomenon, etc. Expand the scope of application and reduce the effect of secondary damage
Inactive Publication Date: 2016-11-09
YANCHENG INST OF IND TECH
View PDF8 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] The biocompatibility of bacterial cellulose is very good. If bacterial cellulose fiber is used for drug-loaded fiber, due to its hydrogel properties, not only the strength is poor under wet c
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0026] An anti-inflammatory drug-loaded fiber with a composite structure for transdermal administration and its preparation method:
[0027] The first step: the preparation of bacterial cellulose fibers. With N,N-dimethylacetamide / lithium chloride (DMAc / LiCl), zinc chloride (ZnCl 2 ), ionic liquid, N-methylmorpholine aqueous solution (NMMO) any one of the solvents, the bacterial cellulose solid content of 1% (w / w) spinning solution prepared at room temperature, wet spinning, dry spinning Bacterial cellulose fibers were prepared by conventional spinning or dry-jet wet spinning.
[0028] The second step: drug-loading finishing of bacterial cellulose fibers. The drugs are anti-inflammatory drugs, including aspirin, paracetamol, indomethacin, naproxen, naproxen, diclofenac, ketoprofen, ibuprofen, nimesulide, rofecoxib , celecoxib, etc., or a combination thereof, anti-inflammatory drugs and transdermal enhancers (one of azone, oleic acid, N-methyl-2-pyrrolidone, propylene glycol...
Embodiment 2
[0032] In this example, the mass concentration of bacterial cellulose A spinning solution is 1.5%, the dissolved concentration of anti-inflammatory drug B is 60 g / L (w / w), and the dissolved concentration of transdermal enhancer C is 60 g / L (w / w). / w), polyacrylonitrile D is a dilute solution with a solution mass concentration of 1% (w / w), and the other methods are the same as in Example 1.
Embodiment 3
[0034] The mass concentration of bacterial cellulose A spinning solution was 2%, the dissolved concentration of anti-inflammatory drug B was 70 g / L (w / w), and the dissolved concentration of transdermal enhancer C was 70 g / L (w / w). Acrylonitrile D solution is a dilute solution with a mass concentration of 3% (w / w), and other methods are the same as in Example 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses composite-structure bacterial cellulose/polyacrylonitrile medicine-carrying fiber prepared with an anti-inflammatory agent as the model medicine according to the characteristics of compactness and hydrophobicity of polyacrylonitrile. The composite medicine-carrying fiber is prepared from bacterial cellulose, polyacrylonitrile, anti-inflammatory agent and a medicine skin penetration enhancer through three steps. Compared with bacterial cellulose fiber, the bacterial cellulose/polyacrylonitrile composite medicine-carrying fiber has greatly improved mechanical performance, dry-strength larger than or equal to 3.0 cN/dtex, wet-strength larger than or equal to 2.0 cN/dtex, dry extensibility of 15% and wet extensibility of 25%, and overcomes the defect that bacterial cellulose is poor in wet-strength; the fiber has a skin-core structure prepared through polyacrylonitrile coating soaking treatment, and coarse surface appearance becomes smooth; the fiber has better medicine slow-release property, and the slow-release time can be controlled to be 1-10 days according to a composite process; the composite medicine-carrying fiber can be woven into a suture with anti-inflammatory and analgesic functions and can also be woven into fabric and used as external dressing with anti-inflammatory, anti-rheumatism, analgesic, anti-febrile and anti-coagulation functions.
Description
technical field [0001] The invention relates to an anti-inflammatory drug-loaded fiber with a composite structure for transdermal administration and a preparation method thereof, belonging to the technical field of material processing. Background technique [0002] Anti-inflammatory drugs are drugs used to treat inflammation in response to tissue damage. There are two types of anti-inflammatory drugs: one is steroidal anti-inflammatory drugs, that is, the glucocorticoid hydrocortisone secreted by the adrenal cortex and its synthetic derivatives. The other category is non-steroidal anti-inflammatory drugs (NSAIDs, non-steroid-anti-inflammatory drugs), that is, antipyretic, analgesic and anti-inflammatory drugs referred to in medical practice. Non-steroidal anti-inflammatory drugs are a class of anti-inflammatory drugs that do not contain a steroidal structure. They exert anti-inflammatory effects by inhibiting the synthesis of prostaglandins, inhibiting the aggregation of ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more