High-strength collagen base artificial bone repair material

A technology of collagen-based human and repair materials, which is applied in the field of high-strength collagen-based artificial bone repair materials and artificial bone materials. performance, good biological activity, broad application prospects

Active Publication Date: 2014-06-04
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the necessary sintering process in the preparation of calcium-phosphorus bioceramics greatly limits the chemical composition of such products, and organic components such as collagen that are beneficial to bone tissue repair cannot be compounded in the final product
Sintered calcium-phosphorous ceramics are also unsuitable as bone repair materials in load-bearing areas due to their brittleness
On the other hand, it has been reported in the literature that nano-sized hydroxyapatite is more conducive to the osteogenic differentiation of cells than micron-sized particles. Even if the raw material is nano-sized hydroxyapatite (particle size<100nm), its grain also grows to the micron scale, which greatly reduces the osteogenic activity of the material
[0006] Therefore, the existing technologies and products are still unable to provide bioactive materials for bone repair in the weight-bearing parts of the human body, and cannot meet the needs of this type of clinical repair.

Method used

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  • High-strength collagen base artificial bone repair material
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  • High-strength collagen base artificial bone repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0059] Embodiment 1, preparation of high-strength collagen / nano calcium phosphate composite artificial bone

[0060] figure 1 Shown is the process flow chart of the preparation method of the high-strength collagen-based artificial bone repair material of the present invention. according to figure 1 In the steps shown, the preparation method of high-strength collagen / nano-calcium-phosphate composite artificial bone is:

[0061] Step S1-1, dissolving 1 g of collagen in 2 L of 0.5 mol / L acetic acid solution to prepare a collagen acid solution;

[0062] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 100 mL of CaCl with a concentration of 1 mol / L dropwise 2 solution;

[0063] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 100 mL of Na with a concentration of 0.6 mol / L dropwise 2 HPO 4 solution;

[0064] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 1 mol / L NaOH solution dropwise unt...

Embodiment 2

[0071] Embodiment 2, preparation of high-strength collagen / nano calcium phosphate / polylactic acid composite artificial bone

[0072] First, the collagen / nano-calcium phosphate composite material was prepared as described in Steps S1-1 to S1-5 of Example 1.

[0073] Then, the preparation of the collagen / nano-calcium phosphate / polylactic acid composite material includes:

[0074] Step S2-1, taking 1 g of polylactic acid with a molecular weight of 100,000 and dissolving it in 10 mL of 1,4-dioxane at 50°C to prepare a polylactic acid solution;

[0075] Step S2-2, adding 1 g of the dry powder prepared in step S1-5 to the polylactic acid solution obtained in step S2-1, and mixing uniformly to prepare a collagen / nano calcium phosphate / polylactic acid mixed suspension system;

[0076] Step S2-3, freeze the mixed suspension system obtained in step S2-2 at -10°C for 2 hours, then freeze-dry for 48 hours, and then transfer to a vacuum drying oven with a vacuum degree of -0.1MPa and dry ...

Embodiment 3

[0080] Embodiment 3, preparation of high-strength collagen / nano calcium phosphate / polylactic acid-glycolic acid copolymer composite artificial bone

[0081] Materials were prepared according to the steps described in Example 2. Wherein, the polylactic acid described in step S2-1 is replaced with a polylactic acid-glycolic acid copolymer (lactic acid / glycolic acid=50 / 50) with a molecular weight of 120,000, the applied pressure in step S3-2 is 155kN, and the remaining operating and process parameters are not changed. Change, so as to obtain collagen / nano calcium phosphate / polylactic acid-glycolic acid copolymer composite artificial bone.

[0082] After testing, the composite artificial bone density is 1.85g / cm 3 , the compressive strength is 145MPa, and the bending strength is 84MPa, which is suitable for the repair of human bone defects in load-bearing parts.

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Abstract

The invention provides a high-strength collagen base artificial bone repair material which can be used for repairing the bone defect of bearing parts of a human body. The high-strength collagen base artificial bone repair material has chemical composition and structure formed by self-assembly of nanometer calcium phosphate and collagen molecules, so that the high-strength collagen base artificial bone repair material has a biomimetic mineralization structure similar to the natural bone tissue of the human body. In terms of mechanical properties, the material has the mechanical strength similar to that of the cortical bone of the human body and can be used for repairing the bone defect of the bearing parts of the human body. The invention also provides a preparation method of the high-strength collagen base artificial bone repair material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an artificial bone material, in particular to a high-strength collagen-based artificial bone repair material that can be used for repairing bone defects in weight-bearing parts of a human body. technical background [0002] Clinically, bone defects in load-bearing parts caused by trauma, infection, bone tumors, etc. are very common. For the repair of such defects, people have developed a variety of materials such as titanium alloys, polyetheretherketone, and carbon fibers. However, these materials have mechanical properties and There are respective defects in biological activity. The elastic modulus of titanium alloy materials is 4 to 10 times that of human bones, and there is a phenomenon of stress shielding in clinical applications, which is not conducive to bone repair. Carbon fiber materials are prone to wear debris on the surface, triggering tissue inflammation at the repa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/48A61L27/50A61L27/56A61L27/40
Inventor 王昶明崔菡仇志烨
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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