113 results about "Post implantation" patented technology

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention discloses an angle-adjustable or deployable multi-stage anchoring insertion sheet system, and relates to the technical field of medical instruments, the angle-adjustable or deployable multi-stage anchoring insertion sheet system comprises a hollow box body, and the upper surface and the lower surface of the box body are each provided with at least one insertion sheet outlet; the at least one group of inserting piece driving mechanism is arranged in the box body and is used for generating linear driving force; the at least two insertion sheet assemblies are accommodated in the box body in an initial state, and each insertion sheet assembly is in driving connection with the insertion sheet driving mechanism; according to the intervertebral fusion cage, the secondary anchoring part capable of moving relative to the basic anchoring part is arranged, so that the anchoring angle or the opening degree of the fusion cage can be adjusted according to a vertebral form operation of a patient after the fusion cage is implanted, the adaptability to different anatomic forms is improved, and a more flexible anchoring scheme is provided for an intervertebral fusion operation.

A surgical fixation assembly and related method of fusing a sacroiliac joint are described herein. The surgical fixation assembly includes a compression member, a stabilizer, and a locking element. The compression member is rotatably implantable into two bone segments separated by a joint. The stabilizer is configured for coupling with the compression member in situ after implantation of the compression member and prevents rotation of the compression member after implantation. The locking element is provided on the stabilizer and is moveable from a first position that allows coupling of the stabilizer and compression member to a second position that prevents uncoupling of the stabilizer from the compression member.

The invention provides a mechanical property dynamic prediction method after stent implantation, and the method combines CT image three-dimensional reconstruction, finite element simulation analysis and data-driven modeling to construct a whole-process mapping relation from'stent model structure parameters-new bone growth characteristics-mechanical response '; a training data set is constructed through a large amount of simulation data, a proper analysis method is introduced to establish a prediction model, the performance change trend under different structural designs can be efficiently predicted, stent parameters can be reversely optimized, the individualized adaptability and the function-oriented design capability of the stent are improved, and the method is suitable for large-scale popularization and application. Meanwhile, a complex structure parameter space is covered by combining real bone growth data simulation, and the requirement for rapid optimization design of the stent is met; according to the method, the minimum repetitive unit of the model structure is improved and optimized, and meanwhile, the real growth condition of the new bone tissue is combined, so that the method can be more accurately and truly applied to predicting the mechanical property of the bone tissue in the growth process after the stent is implanted.

The embodiment of the utility model provides an orthosis and an orthosis system for scoliosis. The orthosis for scoliosis comprises a sleeve, a reset piece, a first rod body and a second rod body. The sleeve is provided with a containing cavity, the reset piece is arranged in the containing cavity, and the end of the sleeve is provided with a stop part; the first rod body and the second rod body are oppositely arranged on the sleeve, an anti-dislocation part is arranged at the end of the second rod body, the anti-dislocation part is arranged in the containing cavity in a sliding and penetrating mode, and the anti-dislocation part abuts against the reset piece and can abut against the stop part. Therefore, the anti-disengagement part is prevented from being disengaged from the containing cavity. Therefore, the orthosis for scoliosis avoids the problem of correction failure caused by the fact that the rod body slides out of the sleeve, and further has the advantage of improving stability after implantation.

This invention relates to the field of orthopedic surgical risk assessment, and in particular to a method and system for orthopedic surgical risk assessment. By acquiring preoperative and intraoperative data of a patient's orthopedic surgery, the method preprocesses the preoperative and intraoperative data, extracts the spatial features of bone microstructure from the initial orthopedic surgical data using a cascaded feature extraction network, calculates the correlation weights between imaging data and biological signals through a cross-modal attention mechanism, and constructs a patient-specific bone model based on finite element analysis to simulate the characteristic orthopedic surgical data in real time. The method simulates the distribution of joint contact stress at different osteotomy angles, the impact of micromotion thresholds at the bone implant interface and hemodynamic changes on the bone healing microenvironment after internal fixation device implantation, significantly reducing complications caused by improper operation and improving the surgical success rate.

The application discloses a kind of implant and its preparation method and application, the implant includes material body, metal oxide layer and mixed crystal layer, the mixed crystal layer is located the surface of the metal oxide layer;The metal oxide layer includes metal oxide nanorod array;The metal oxide is selected from zinc oxide, silver oxide or its combination;The mixed crystal layer includes CaP crystal and metal oxide crystal.The implant of the application is sterilized by the bacteriostatic metal ion generated by physical puncture and degradation of metal oxide nanorod, has good antibacterial effect to gram-positive bacteria and gram-negative bacteria, prevents infection;It can also relieve post-implantation inflammatory response, reduce immune response under post-implantation infection, shorten wound healing time.In addition, due to the coating effect of mixed crystal layer on metal oxide layer, the bacteriostatic metal ion is slowly released, the release time is long, and long-lasting antibacterial effect can be achieved, and post-implantation inflammatory response can be reduced.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

The utility model relates to medical equipment technical field, concretely is a kind of positioning drill for dental implant surgery. Including driving rod, the one end of driving rod is connected with annular drill bit, the end of annular drill bit is equipped with tooth edge, the inside of annular drill bit is provided with the positioning member extending outward, the middle part of driving rod is provided with fixed ring, driving rod and located the side activity sleeve of annular drill bit is equipped with sleeve, driving rod and located between sleeve and fixed ring is equipped with spring, the side of sleeve and annular drill bit is open structure. Through different specifications sleeve, the safety distance required around implant can be guaranteed;Annular drill bit marks edge, the remaining bone mass around implant after implantation and the distance with adjacent tooth can be intuitively displayed;In the process of continuing to prepare hole, if deviation is generated due to bone density uneven, it can be easily observed and adjusted;Reduce the additional cost generated by the production of guide plate and navigation, reduce the burden of patient.

The invention relates to the technical field of metal surface treatment, in particular to a treatment process of a hydrophilic implant. According to the process, the implant is sequentially subjected to sand blasting and acid etching, compound acid solution activation, gradient alkaline neutralization, multi-stage ultrasonic cleaning, low-temperature plasma modification, nitrogen protection ultraviolet radiation and normal saline sealing storage treatment. Through a multi-step synergistic effect, a stable hydrophilic micro-nano structure is constructed on the surface of the implant, a large number of Ti-OH hydrophilic groups are formed, carbon and hydrogen atom adsorption is effectively isolated, and the problems that the hydrophilicity of an existing implant is prone to loss, osteoblast climbing is difficult, and the healing period is long are solved. The implant treated by the process is durable and stable in hydrophilicity, the healing period after implantation is shortened to about one month, the planting survival rate is remarkably increased, the process is green and safe, and industrial production can be realized.

The invention discloses an anti-drifting peritoneal dialysis pipeline convenient to fix, relates to the technical field of peritoneal dialysis pipelines, and aims to solve the technical problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and a catheter is prone to shifting and even falling off due to accidental pulling. Comprising a fixing bellyband surrounding the waist and belly, a first dialysis tube arranged at a subcutaneous tunnel section, a fixing mechanism and an auxiliary mechanism. According to the invention, the compressible elastic anchor wing is in a dry and compressed state in the implantation process, rapidly absorbs tissue fluid after implantation to generate hydration expansion and recover an outward expansion form, and is matched with micron-sized pyramid-shaped textures on the surface of the micro-texture biological anchoring area to provide an ideal scaffold for fibroblast attachment and collagen deposition; the catheter can be mechanically interlocked with surrounding abdominal wall fascia and subcutaneous fiber adipose tissue, the initial subcutaneous stability of the dialysis catheter is guaranteed, and the problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and the catheter is prone to displacement and even disengagement due to accidental pulling are solved.

The invention discloses a shapeable bone repair material capable of being implanted in a positioning manner and a preparation method thereof. The interior of the bone repair material is a core layer made of a gelatin, gallic acid and hydroxyapatite particle composite material, and the exterior of the bone repair material is a porous spongy collagen wrapping layer; the density of the wrapping layer is 20-100mg / cm < 3 >; the density of the core layer is 100-800 mg / cm < 3 >; and the particle size of the hydroxyapatite particles is 0.1-2 mm. The collagen sponge on the outer layer of the material wraps the gelatin / hydroxyapatite composite material, so that the problems of loose structure, weak binding force and displacement and powder falling after implantation of bone meal or collagen bone meal composite materials are solved, stimulation and trauma of bone meal particles to surrounding tissues can be avoided, and the conditions of bone meal discharge, bone grafting part collapse and the like are avoided. And in the self tissue regeneration process, the collagen component is degraded and absorbed, and the hydroxyapatite is fused with the new bone, so that bone regeneration is realized, and the success rate of tooth implantation can be improved.

This invention discloses a self-assembled joint implant integrating hard and soft tissue and its forming method. The implant comprises two parts: a hard tissue structure and a soft tissue structure. The hard tissue structure includes a dense hard tissue structure and a porous, loose hard tissue structure with a bidirectional gradient porosity. The soft tissue structure includes a hard soft tissue structure and a soft soft tissue structure, with different ratios of hydroxyapatite and hydrogel. The contact surfaces of the hard and soft tissue structures have corresponding serrated structures, achieving stable assembly through a combination of interference fit and friction. Furthermore, the hard tissue undergoes surface modification and is combined with a binder to promote the stability of the hydrogel applied before and after assembly, improving the firmness of the soft-hard tissue bond. The overall structure and materials of this invention exhibit continuous gradient continuity, enabling a stable transition of properties at various interfaces and reducing instability, thereby promoting post-implantation recovery and preventing loosening.

The present teaching provides device and method of use thereof, for example, for the placement of a medical implant inside the cerebrovasculature. Various embodiments of the present teachings include a medical implant, a delivery system, and an Optical Coherence Tomography (OCT) imaging system. The OCT imaging system is used to reveal the three dimensional (3D) volumetric structure of the vascular network, as well as vessel density and geometric features, blood flow velocity, flow rate, and other data useful for selecting suitable medical implant as well as treatment location. This OCT imaging system is also used to guide the medical implant deployment and post implantation assessment.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.

A medical implant is provided defined as an electrospun hollow-cored porous suture ring. The suture ring is a continuous ring made by rolling up circular sheet of electrospun material, which was electrospun over a cylindrical target. The suture ring, upon implantation, is capable of being absorbed and replaced by natural tissue due to ingrowth of cells and nutrients into pores of the electrospun hollow-cored biodegradable suture ring. The suture ring addresses at least some of the existing problems with suture or sewing rings.

The application discloses a single-layer composite stent, relates to the field of medical devices, and discloses a single-layer composite stent which comprises a supporting main body and a woven wire mesh, wherein the supporting main body is a self-expanding net tube structure, and a plurality of through holes are arranged at intervals in the supporting main body; the woven wire mesh is arranged in the through holes and wound on the supporting main body; the composite stent can treat stenosis lesions in blood vessels through the supporting main body, and effectively prevent the shedding of plaques at the stenosis lesions through the woven wire; the wall thickness of the single-layer stent is adopted to realize the effect of a double-layer stent, the loss of a blood vessel cavity is minimized, the blood flow is fully ensured to be smooth, and the single-layer composite stent has remarkable clinical significance; the single-layer composite stent has good firmness and composite strength, and is not prone to delamination or even breakage and shedding after implantation, so that other complications are effectively avoided; meanwhile, the release resistance of the single-layer composite stent can be effectively reduced, and the single-layer composite stent is convenient for doctors to operate.

Expandable spinal fusion devices, systems, and methods of using them are provided, and they can be inserted in a subject in a collapsed state through a small surgical corridor, and the expand cephalocaudal only, transverse only, or in both directions, in which direction of expansion can also be obtained independently, if desired, after the insertion. These inventions are valuable in reducing risk and surgical complexity, allowing for an on-the-fly selection of a desirable width footprint, a desired control of height expansion through a gradual cephalocaudal expansion, and a desired control of the alignment of the adjacent vertebral bodies. Devices, systems, and methods are also offered to provide a desired control of the contact area desired between the device and the upper and lower vertebral endplates achieved, for example, using an interdigitated endplate system.

The application discloses an intramedullary fixation device for tubular bone fracture, which comprises an intramedullary nail, an anchoring structure, an adjusting mechanism and an angle locking mechanism; the intramedullary nail is used for implanting into a bone marrow cavity to provide a fracture fixation support; the anchoring structure is movably arranged on the intramedullary nail, and the anchoring structure is provided with at least one anchoring wing, and the anchoring wing has multiple unfolding angles; the adjusting mechanism is in transmission connection with the anchoring structure, and the adjusting mechanism is used for driving each anchoring wing to switch between different unfolding angles; the angle locking mechanism is linked with the adjusting mechanism, and the angle locking mechanism is provided with multiple preset unfolding angle gears, and the angle locking mechanism is used for locking the anchoring wing at a target unfolding angle. The application solves the problem that the existing intramedullary nail cannot be graded and adjusted after implantation.

This invention relates to the field of artificial joint prosthesis technology, and discloses an anatomical femoral condyle knee joint prosthesis that does not preserve the cruciate ligament. The prosthesis includes a femoral condyle, a tibial plateau pad, and a tibial plateau support. The femoral condyle comprises a medial condyle and a lateral condyle. The medial and lateral condyles, in lateral view, respectively form medial condyle curve contours and lateral condyle curve contours. The medial condyle curve contour is located lateral to the lateral condyle curve contour, and the movement trajectory length of the medial condyle curve contour is 15%-25% longer than that of the lateral condyle curve contour. The tibial plateau pad has medial condyle curved grooves and lateral condyle curved grooves that respectively conform to the medial and lateral condyles. The slope of the medial condyle curved groove is greater than that of the lateral condyle curved groove. This invention provides an anatomical femoral condyle knee joint prosthesis that does not preserve the cruciate ligament, solving the problem of poor compatibility between existing prostheses and surrounding tissues after implantation.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The invention provides a dental implant which comprises an implant body, and an implant thread matched with an alveolar bone is formed on the outer side wall of the implant body. The implant thread is made of a non-absorbable material and has good mechanical strength and biocompatibility. The surface of the implant thread is covered with the absorbable alloy layer, and the absorbable alloy layer is designed to be in a sharp thread form, so that bone injury in the implanting process is reduced. The absorbable alloy layer can be slowly absorbed by the alveolar bone after being implanted, so that the pressure on the cancellous bone is slowly reduced, the bone tissue healing is promoted, the stability of the dental implant is gradually consolidated and maintained, the reduction of peripheral inflammatory response or foreign body response is facilitated, and the long-term stability of the dental implant after being implanted is finally improved.

The invention provides a hip protection device for a femoral head, and belongs to the technical field of medical apparatuses and instruments. A casing pipe; the sliding groove is connected into the sleeve in a sliding mode. The ejector rod is fixedly connected to one side end of the sliding groove; the elastic clamping piece is positioned in the sleeve; the spring is fixedly connected to the end, close to the sliding groove, of the screw, stable support and protection can be provided between the femoral head and the hip joint through sliding connection of the sliding groove and the ejector rod and cooperation of the elastic clamping piece and the spring, and accurate positioning of the device on the femoral head can be guaranteed through the design of the limiting ring and the positioning block; the stability is further improved, the clinical problem after a femoral head reconstruction rod product is implanted is effectively solved, filler or medicine is injected, treatment and recovery of the femoral head of a patient can be accelerated, the clinical effect of the prosthesis is effectively optimized, the bearing area of the femoral head can be effectively adjusted and enlarged, and stress concentration is avoided; and treatment and recovery of the femoral head of the patient can be accelerated.

This invention belongs to the field of biomaterials technology, specifically relating to a porous metal-ceramic composite scaffold for bone repair in diabetes and its preparation method. This invention uses tetrapodized zinc oxide as a three-dimensional stable pore-forming template, constructing an overall preparation route of "high-energy ball milling – t-ZnO template – SPS – etching," achieving uniform composite of high-melting-point metal and bioactive ceramic. This results in a porous metal-ceramic composite scaffold with uniform tissue structure, strong interfacial bonding, controllable pore structure, adjustable mechanical properties, and multiple bioactivities including osteogenic, immunogenic, and vascularization activities, significantly improving post-implantation bone integration efficiency and biofunctionality.

The invention discloses an integrated heart valve stent with relatively short axial height, and relates to the field of heart valve stents. The invention provides an integrated heart valve stent with shorter axial height, which comprises a main body stent, and the main body stent comprises an upper stent and a lower stent which are sequentially connected from top to bottom along the axial direction of the main body stent and are integrally formed. A plurality of upper grids which are sequentially arranged in the circumferential direction of the upper support are arranged in the upper support, the upper grids are first grids or second grids, and at least one upper grid is the second grid. A plurality of lower grids are sequentially arranged in the lower support in the circumferential direction of the lower support. The top of the first grid and the top of the second grid are arrow-shaped, the arrow height of the top of the second grid is smaller than that of the top of the first grid, and the arrow included angle alpha of the top of the second grid is 60-130 degrees. The axial height of the main body stent is reduced, the bending capacity of the main body stent can be enhanced, the aortic arch passing capacity of the main body stent is improved, and meanwhile, the occurrence risk of conduction block after implantation is reduced.

A bioabsorbable magnesium alloy for use in an orthopedic implant comprises magnesium, zinc in an amount of 0.5-4 weight percent, calcium in an amount of 0.1-1.5 weight percent, and manganese in an amount of up to 1.5 weight percent. The alloy exhibits a controlled, multi-phase absorption profile when exposed to physiological conditions, including an initial period of minimal degradation, followed by a steady-state phase, and concluding with an accelerated absorption phase. A method of manufacturing the alloy includes casting, solution treating, and extruding. An orthopedic implant device formed from the alloy comprises a body that exhibits the controlled, multi-phase absorption profile when implanted.

This invention provides an intervertebral disc prosthesis and an intervertebral disc prosthesis assembly. The intervertebral disc prosthesis includes: a superior endplate; a inferior endplate, with a first end of the superior endplate hinged to a first end of the inferior endplate, and the superior and inferior endplates are capable of relative oscillation; and a floating support member disposed between the superior and inferior endplates. The floating support member includes a first support plate, a second support plate, and an elastic member. The first end of the first support plate is hinged to a first end of the second support plate, and the first and second support plates are capable of relative oscillation. The first ends of the first and second support plates are located between the first ends of the superior and inferior endplates. The elastic member is disposed between the first and second support plates and applies elastic force to cause the first support plate to abut against the superior endplate, and the second support plate to abut against the inferior endplate. The technical solution of this application effectively solves the problem of poor post-implantation stability caused by the fixed angle between the superior and inferior endplates of intervertebral disc prostheses in related technologies.

The invention relates to the technical field of artificial prostheses, and discloses an artificial cervical intervertebral disc based on a biological bionic structure, which comprises an upper end plate, a lower end plate and an elastomer core arranged between the upper end plate and the lower end plate, the elastomer core comprises a front annulus fibrosus, a nucleus pulposus and a rear annulus fibrosus; the front fiber ring is composed of an outer side fiber layer, a middle transition layer, an inner side fiber layer and front collagenous fibers located among the fiber layers. The artificial cervical intervertebral disc can be more naturally matched with the physiological movement mode of vertebrae after being implanted by adopting differentiated arrangement of front and rear fibrous rings, gradient dip angle design of collagenous fibers, elastic deformation characteristics of nucleus pulposus and material combination with different elastic moduli; the irregular-shaped end plate is more attached to the cervical vertebra hook process joint and adapts to multi-direction complex movement.

The utility model belongs to the technical field of medical instruments, and discloses a coronary artery bifurcation lesion implantation rear ridge support beam optimized juxtaposition catheter which comprises a micro catheter, the micro catheter comprises a main catheter and two branch catheters, one ends of the two branch catheters are fixedly arranged at one end of the main catheter in a communicated mode, and a gap is formed between the two branch catheters; propelling assemblies are arranged on the surfaces of the main catheter and the two branch catheters; a large arc convex ring is arranged on the surface of the main catheter and located on one side of the branch catheters, and small arc convex rings are arranged on the sides, away from the main catheter, of the two branch catheters. In conclusion, the device has the advantages that the catheter can be firmly fixed in the blood vessel and cannot move, and meanwhile, the stent can be finely adjusted by means of the arrangement of the surface of the catheter.

The embodiment of the application relates to the technical field of medical coating materials, and particularly relates to a method for forming an active coating on the surface of a degradable occlusion device and the degradable occlusion device, the method comprising the following steps: preparing perfluorohexane liposomes loaded with stromal cell-derived factor-1 alpha (SDF-1 alpha); preparing polylactic acid-glycolic acid copolymer@rapamycin@nitric oxide donor nanoparticles; preparing a methacrylated gelatin-tannic acid hydrogel carrier; mixing the liposomes and the nanoparticles into the hydrogel carrier; soaking the degradable occlusion device in the mixture obtained in the previous step, and performing light crosslinking treatment on the mixture, so that an active coating is formed on the surface of the degradable occlusion device. Therefore, comprehensive consideration of "endothelialization repair in the early implantation period - myocardial tissue remodeling after implantation" is realized, controllable time-sequencing repair of the degradable occlusion device on the heart defect site is ensured, and the endogenous functional repair effect of the heart of a patient is improved.