264 results about "Post implantation" patented technology

The invention discloses a separated modular anchor implantation system with a line, and relates to the technical field of medical apparatuses and instruments. The separated modular suture anchor implanting system comprises an inserter and a storage box, the inserter comprises an insertion rod, and an insertion part is arranged at the head of the insertion rod. An anchor and a suture line are stored in the storage box, an inlet and an outlet are formed in the two ends of the storage box respectively, and the insertion rod can be inserted into the storage box through the inlet, so that the insertion part is connected with the anchor in an inserted mode, the anchor is pushed out of the outlet, and the assembly of the inserter and the anchor is completed; after the anchor nail is implanted by the inserter, the insertion part and the anchor nail can be disconnected and the suture line can be directly withdrawn by moving the inserter in the direction opposite to the implanting direction without being removed by a doctor, so that independent storage of the anchor nail and the suture line is realized, and meanwhile, free assembly of the anchor nail and the inserter is realized; due to the modular structural design, the anchor can be selected and matched according to actual operation requirements, the inserter can be repeatedly used, waste of medical resources is reduced, and environmental protection is facilitated.

A system and method to identify, convey, and reduce the risk of hip dislocations following hip replacement surgery. Preoperative images are used to identify the pelvic tilt of a patient while the patient is in a sitting position, a standing position, and a supine position. Based on the pelvic tilt and pelvic mobility depicted in the preoperative images, the system can identify a quantitative and / or qualitative risk of hip dislocation when the patient is seated, standing, and lying. During surgery, an intraoperative image can confirm the acetabular cup orientation once implanted and the system can determine the risk of hip dislocation when patient is in the supine position. The system can also extrapolate the dislocation risk when the patient is seated and standing based on acetabular cup position and orientation depicted in the intraoperative image.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and / or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and / or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.

The invention relates to the technical field of medical engineering, in particular to a hemodynamic simulation analysis system for coronary stent implantation. The system comprises a coronary blood vessel anatomical structure aided design module, a coronary stent finite element model design module, a post-implantation hemodynamic simulation analysis module and a pre-implantation and post-implantation blood flow state evaluation module, and can obtain coronary medical image data of a patient and perform blood vessel anatomical structure geometric analysis and blood vessel three-dimensional model aided design. Generating a three-dimensional model of the coronary vessel anatomical structure of the patient; a coronary stent finite element model is designed and generated through a geometric feature set of the coronary stent, a hemodynamic feature parameter set before stent implantation is obtained, blood flow boundary limitation analysis and coronary stent implantation dynamics simulation analysis are carried out, and meanwhile blood flow state evaluation analysis before and after stent implantation is carried out. And generating a blood flow state simulation evaluation report before and after stent implantation. According to the method, the change of the blood flow state after the stent is implanted can be efficiently and accurately analyzed.

Layered materials for using in implants, such as hernia repair implants. The layered materials may include a first layer including a substrate (e.g., mesh) and a second layer including a sheet of anti-adhesive material. The layers may be attached at small attachment sites that are separated by regions in which the layers are not attached, to provide a highly compliant implant. The compliance of the implant may match that of a patient's body upon implantation and / or over time following implantation.

The embodiments provide various interbody fusion spacers, or cages, for insertion between adjacent vertebrae. The cages may have integrated ratchet assemblies that allow the cage to change size and angle as needed, with little effort. The cages may have a first, insertion configuration characterized by a reduced size to facilitate insertion through a narrow access passage and into the intervertebral space. The cages may be inserted in a first, reduced size and then expanded to a second, larger size once implanted. In their second configuration, the cages are able to maintain the proper disc height and stabilize the spine by restoring sagittal balance and alignment. Additionally, the intervertebral cages are configured to be able to adjust the angle of lordosis, and can accommodate larger lordotic angles in their second, expanded configuration. Further, these cages may promote fusion to further enhance spine stability by immobilizing the adjacent vertebral bodies.

A method includes receiving by a controller, a surgeon-specific surgery profile for an implantation of an implant into a joint, implant profiles, a patient-specific post-surgery desired functional profile of the joint after the implantation, and bone registration data for a first bone member and a second bone member of a patient are inputted into a surgical plan model to generate a surgical plan. The surgical plan model is designed to achieve the patient-specific post-surgery desired functional profile based at least in part on a plurality of dependencies between a plurality of surgical parameters, the implant profiles, at least one functional parameter representative of the expected functional performance of the joint, and movement-related data of the joint. The surgical plan is outputted on a graphical user interface (GUI) on a surgery assistant device to facilitate the implantation.

The invention discloses a bionic lantern frame composite internal fixing device and a preparation method, and relates to the technical field of orthopedic medical instruments, the bionic lantern frame composite internal fixing device comprises an implant and a multi-rod bridging structure, the multi-rod bridging structure is composed of a plurality of longitudinal connecting rods and transverse locking nails, and the implant is composed of a plurality of multi-level bionic structures; the multi-layer bionic structure comprises two hexagonal upper and lower layer structures which are symmetrically arranged and a middle spiral layer structure arranged between the two hexagonal upper and lower layer structures. According to the invention, inspired from honeycomb and ox horn macro-microstructure, the multi-level bionic structure prepared by adopting a coupling bionic technology has excellent mechanical properties and strong buffering and vibration absorbing capabilities, can be effectively matched with the mechanical properties of natural bones, and can effectively avoid secondary injury and stress shielding effect after implantation of a patient; the composite coating introduced through an electrochemical deposition method solves the problems that a single implant structure is insufficient in biocompatibility, insufficient in antibacterial property and weak in osteogenic differentiation capacity.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and / or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-α and anti-TGF-β1 action for the treatment of hepatic fibrosis.

The utility model provides an atlantoaxial joint fusion cage which comprises a fusion cage body with round and blunt peripheral corners, the fusion cage body is an ellipse-like hollow polyhedron, the hollow polyhedron is divided into a front supporting section and a rear supporting section, and the front supporting section is a cone composed of four faces or is in a streamline shape so as to facilitate implantation of the fusion cage; the rear supporting section is in a cuboid shape, the rear end face of the rear supporting section is sequentially provided with an opening groove, a rectangular opening and a screw hole from one side to the other side, an inserting piece is arranged in the fusion cage body, the inserting piece penetrates through the rectangular opening and then inclines upwards, and barb structures are arranged on the two sides of the inserting piece. The anatomical structure conforming to the atlantoaxial joint gap in appearance is adopted, after the anatomical structure is implanted into the atlantoaxial joint gaps on the two sides, surrounding loose joint capsules generate tension so that the atlantoaxial joints can be immediately stabilized, bone grafting fusion can be faster and better in the internal fixation stable period, and then the purpose of atlantoaxial stabilization is achieved; the atlantoaxial dislocation or instability can be effectively treated.

The invention discloses an angle-adjustable or deployable multi-stage anchoring insertion sheet system, and relates to the technical field of medical instruments, the angle-adjustable or deployable multi-stage anchoring insertion sheet system comprises a hollow box body, and the upper surface and the lower surface of the box body are each provided with at least one insertion sheet outlet; the at least one group of inserting piece driving mechanism is arranged in the box body and is used for generating linear driving force; the at least two insertion sheet assemblies are accommodated in the box body in an initial state, and each insertion sheet assembly is in driving connection with the insertion sheet driving mechanism; according to the intervertebral fusion cage, the secondary anchoring part capable of moving relative to the basic anchoring part is arranged, so that the anchoring angle or the opening degree of the fusion cage can be adjusted according to a vertebral form operation of a patient after the fusion cage is implanted, the adaptability to different anatomic forms is improved, and a more flexible anchoring scheme is provided for an intervertebral fusion operation.

A clip for securing leaflets of a heart or vein valve includes a hub having a pair of anti-tangling spring-biased outer arms coupled to a lower end of the hub. A pair of anti-entanglement spring-biased inner arms are adjacent to the outer arms and coupled to the upper end of the hub. The clip may incorporate an adjustable spacer and may be retrieved after implantation. When the outer arm and the inner arm are biased relative to each other in an open position, a delivery catheter is used to position the valve clip proximate a target valve. After the valve leaflet is located between the open outer and inner arms, the biasing force may be released to allow the clip to self-close on the valve leaflet.

The invention discloses a preparation method of a bionic beetle skeleton implant, and belongs to the field of femoral implantation. The bionic structure characteristics of beetle elytra and cuticle are creatively combined, the mechanical strength and structural stability of the porous nickel-titanium alloy structure implant are effectively improved through the bionic structure design method, and the long-standing stress shielding effect problem of a traditional femoral metal implant is successfully solved; the porous nickel-titanium alloy bionic skeleton structure prepared by adopting a selective laser melting (SLM) technology not only has good mechanical suitability, avoids rejection and shedding reaction with natural bone tissues after implantation, but also can realize a complete shape memory recovery function in a room temperature environment, and has good application prospects in the field of medical orthopedic implantation.

A guide head and a holding head are arranged at the front end and the rear end of an upper supporting plate and the front end and the rear end of a lower supporting plate respectively, the guide head and the holding head are both in a wedge shape, and the two wedge faces of the guide head and the holding head are in sliding contact fit with the inclined faces of the upper supporting plate and the lower supporting plate respectively. The guiding head and the holding head are driven to be separated and gathered through a thread transmission structure, a nut piece of the thread transmission structure and the guiding head are arranged in a rotation-stopping and movement-stopping mode, a screw piece is matched with the holding head in a rotation-stopping and movement-stopping mode, and the end of a bolt piece is provided with an exposed screwing structure. And a gap which is communicated with the hollow accommodating cavity after the guide head and the holding head are gathered to open the upper supporting plate and the lower supporting plate is formed between the upper supporting plate and the lower supporting plate. An outer frame is not needed, the size is small, lifting can be conducted after implantation, the gap communicated with the hollow containing cavity is formed, the bone can be implanted from the side face after the height is increased, and healing of a diseased part is facilitated.

A surgical fixation assembly and related method of fusing a sacroiliac joint are described herein. The surgical fixation assembly includes a compression member, a stabilizer, and a locking element. The compression member is rotatably implantable into two bone segments separated by a joint. The stabilizer is configured for coupling with the compression member in situ after implantation of the compression member and prevents rotation of the compression member after implantation. The locking element is provided on the stabilizer and is moveable from a first position that allows coupling of the stabilizer and compression member to a second position that prevents uncoupling of the stabilizer from the compression member.

The invention discloses a preparation method of a multi-level zinc-hydrogel heterostructure as a medical implant, and relates to the technical field of medical implants.The preparation method comprises the following steps that firstly, a bionic cattle hoof composite structure model is established based on 3D modeling software, linear array is conducted on the bionic cattle hoof composite structure model for three times, and a linear array is obtained; adjusting the porosity of each bionic cattle hoof composite structure model in a gradient manner to finally obtain a gradient bionic structure model; 2, zinc powder is printed into a gradient bionic structure based on a selective laser melting technology; 3, the gradient bionic structure is placed in a clean mold, the gradient bionic structure is filled with the prefabricated hydrogel in an auxiliary mode, and a multi-level zinc-hydrogel heterostructure is obtained after curing; 4, the multi-level zinc-hydrogel heterostructure is implanted into the defect position of the femur, the prepared multi-level zinc-hydrogel heterostructure can be completely degraded in the human body after being implanted, and the risk of secondary postoperative trauma is avoided.

The invention relates to the field of orthopedic surgery risk assessment, in particular to an orthopedic surgery risk assessment method and system. The method comprises the following steps: acquiring preoperative data and intra-operative data of an orthopedic surgery of a patient, performing data preprocessing on the preoperative data and the intra-operative data, and extracting bone microstructure spatial features in initial orthopedic surgery data by using a cascade feature extraction network; calculating an association weight of the image data and the biological signal through a cross-modal attention mechanism, and constructing a patient specific skeleton model based on finite element analysis to perform real-time scene simulation on the characteristic orthopedic surgery data; the influence of joint contact stress distribution under different osteotomy angles, a bone implant interface micro-motion threshold after implantation of an internal fixation instrument and hemodynamic changes on a bone healing microenvironment is simulated in real time, complications caused by misoperation are remarkably reduced, and the success rate of an operation is increased.

The invention provides a mechanical property dynamic prediction method after stent implantation, and the method combines CT image three-dimensional reconstruction, finite element simulation analysis and data-driven modeling to construct a whole-process mapping relation from'stent model structure parameters-new bone growth characteristics-mechanical response '; a training data set is constructed through a large amount of simulation data, a proper analysis method is introduced to establish a prediction model, the performance change trend under different structural designs can be efficiently predicted, stent parameters can be reversely optimized, the individualized adaptability and the function-oriented design capability of the stent are improved, and the method is suitable for large-scale popularization and application. Meanwhile, a complex structure parameter space is covered by combining real bone growth data simulation, and the requirement for rapid optimization design of the stent is met; according to the method, the minimum repetitive unit of the model structure is improved and optimized, and meanwhile, the real growth condition of the new bone tissue is combined, so that the method can be more accurately and truly applied to predicting the mechanical property of the bone tissue in the growth process after the stent is implanted.

The invention discloses an implantable acellular matrix material and a preparation method thereof, and belongs to the field of biomedical materials. According to the method, natural animal tissues (such as pericardium, achilles tendon or small intestine submucosa) are used as raw materials, a low-temperature chemical combined decellularization treatment technology is adopted, and the method comprises the multi-step synergistic process of pre-cooling soaking balancing, low-temperature enzymolysis, low-concentration surfactant gradient permeation cleaning, low-temperature nuclease degradation, non-crosslinking sterilization and the like. Under the condition that the treatment temperature is strictly kept at 0-8 DEG C, cell components and genetic materials (the residual DNA content is 1t, and the dry weight is 8 ng / mg) are efficiently removed, and meanwhile the natural three-dimensional fine structure of an extracellular matrix (ECM), the integrity of collagen fibrils and key bioactive components (such as glycosaminoglycans (GAGs)) are reserved to the maximum extent. The host immunological rejection reaction of the obtained material is remarkably reduced, host cell ingrowth, vascularization and tissue function reconstruction can be effectively promoted after implantation, and the material is suitable for high-end implantation scenes such as soft tissue repair and regenerative medical stents.

The embodiment of the utility model provides an orthosis and an orthosis system for scoliosis. The orthosis for scoliosis comprises a sleeve, a reset piece, a first rod body and a second rod body. The sleeve is provided with a containing cavity, the reset piece is arranged in the containing cavity, and the end of the sleeve is provided with a stop part; the first rod body and the second rod body are oppositely arranged on the sleeve, an anti-dislocation part is arranged at the end of the second rod body, the anti-dislocation part is arranged in the containing cavity in a sliding and penetrating mode, and the anti-dislocation part abuts against the reset piece and can abut against the stop part. Therefore, the anti-disengagement part is prevented from being disengaged from the containing cavity. Therefore, the orthosis for scoliosis avoids the problem of correction failure caused by the fact that the rod body slides out of the sleeve, and further has the advantage of improving stability after implantation.

This invention relates to the field of orthopedic surgical risk assessment, and in particular to a method and system for orthopedic surgical risk assessment. By acquiring preoperative and intraoperative data of a patient's orthopedic surgery, the method preprocesses the preoperative and intraoperative data, extracts the spatial features of bone microstructure from the initial orthopedic surgical data using a cascaded feature extraction network, calculates the correlation weights between imaging data and biological signals through a cross-modal attention mechanism, and constructs a patient-specific bone model based on finite element analysis to simulate the characteristic orthopedic surgical data in real time. The method simulates the distribution of joint contact stress at different osteotomy angles, the impact of micromotion thresholds at the bone implant interface and hemodynamic changes on the bone healing microenvironment after internal fixation device implantation, significantly reducing complications caused by improper operation and improving the surgical success rate.

The application discloses a kind of implant and its preparation method and application, the implant includes material body, metal oxide layer and mixed crystal layer, the mixed crystal layer is located the surface of the metal oxide layer;The metal oxide layer includes metal oxide nanorod array;The metal oxide is selected from zinc oxide, silver oxide or its combination;The mixed crystal layer includes CaP crystal and metal oxide crystal.The implant of the application is sterilized by the bacteriostatic metal ion generated by physical puncture and degradation of metal oxide nanorod, has good antibacterial effect to gram-positive bacteria and gram-negative bacteria, prevents infection;It can also relieve post-implantation inflammatory response, reduce immune response under post-implantation infection, shorten wound healing time.In addition, due to the coating effect of mixed crystal layer on metal oxide layer, the bacteriostatic metal ion is slowly released, the release time is long, and long-lasting antibacterial effect can be achieved, and post-implantation inflammatory response can be reduced.

Disclosed is an area array micro-needle structure, including a positioning partition plate and at least one micro-needle assembly. The positioning partition plate includes at least two comb structure members stacked to form a plurality of micro-needle holes for a body electrode of a micro-needle to pass through. The positioning partition plate can provide the positioning guiding and fixing effects when the area array micro-needles are implanted, so that accurate implantation of the micro-needles is achieved; the micro-needles can be pulled out after being completely implanted, without damaging human organs and tissues.

An implantable restraint is provided that includes an opening-configured to receive a tissue anchor; a pair of protrusions between the opening and a distal edge, providing an anchor resistance to a longitudinal force; where the pair of protrusions are further configured to separate by a distance approximately equal to the tissue anchor when the longitudinal force exceeds a first predetermined threshold, such that the pair of protrusions moves past the tissue anchor.By providing one or more openings extending through the substrate, the growth of tissue which naturally occurs after implantation is utilized to assist in securing the implantable restraint at the implantation site. By providing the pair of protrusions configured to provide resistance, a high degree of control of the restraining force and the explantation force is provided.

A computer-implemented method is disclosed for generating and displaying predictive synthetic digital radiographs (DRs). The method comprises receiving pre-operative volume data for at least a portion of a patient's anatomy, the data including voxels with radiographic density or other volumetric values. A 3D model of the anatomy is generated, and a 3D model of an implant is placed at a planned position or orientation within the anatomical model. The post-implantation model is translated into planned post-implantation volume data by changing the voxel values corresponding to the implant. One or more predicted synthetic DRs are created from this volume data and presented on a display to show the implant in its planned position and / or orientation.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

The utility model discloses a subcutaneous distractor and a distracting component, the subcutaneous distractor comprises a threading part, a trunk part and a tail part, and the threading part is provided with a thread passing hole for a suture to pass through; one end of the stem part is connected to one side of the threading part, the stem part is in a rod shape, and a plurality of barb-shaped structures with the top ends facing the threading part are arranged on the stem part; the tail part is arranged at the other end of the trunk part and used for being inserted into soft tissue. The distraction assembly comprises the subcutaneous distraction device and a suture. The suture passing hole of the subcutaneous distractor is used for a surgical suture to penetrate through, the barb-shaped structure of the stem structure plays a role in pulling tissue after implantation, and the tail part is used for being inserted into soft tissue. The distraction assembly fixes and distraction subcutaneous tissue through the subcutaneous distraction device and the suture, achieves wound surface reduction and indirect skin traction, and has the advantages that operation is easy, wound holes are rapidly closed, doctors do not need to suture and pull the subcutaneous tissue conveniently, complications are reduced, and the like.

The utility model relates to a lens posterior capsule protection pad used in cataract super breast surgery, which comprises a folding intraocular lens protection pad and a traction rope, the folding intraocular lens protection pad is arc-shaped, can be folded and curled and is injected between a lens nucleus and a posterior capsule through an intraocular lens injector, and the traction rope is arranged between the lens nucleus and the posterior capsule. One end of the traction rope is fixedly connected with the folding intraocular lens protection pad, and the other end of the traction rope is fixed outside the eye. The foldable intraocular lens protection pad can be folded and curled and injected between a lens nucleus and a posterior capsule through the intraocular lens injector, the intraocular lens injector is an existing device, a special implanter is not needed, the production cost is greatly reduced, after the foldable intraocular lens protection pad is implanted, the injector does not need to be continuously used, and the production cost is greatly reduced. The surgical operation time is shortened, the risk that the protection pad cannot be smoothly recycled through an injector is reduced, and the foldable intraocular lens protection pad can be taken out from the anterior chamber through a traction rope after ultrasonic emulsification is completed.