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Isoalantolactone amino derivative and application of salt thereof in preparing anti-tumor medicament

The technology of an anti-tumor drug, inulin, is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., and can solve the problems of low oral bioavailability, low solubility, and poor druggability, etc.

Inactive Publication Date: 2010-10-27
刘华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its low solubility in water, low oral bioavailability, and difficulty in application as an injection, it has poor druggability

Method used

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  • Isoalantolactone amino derivative and application of salt thereof in preparing anti-tumor medicament
  • Isoalantolactone amino derivative and application of salt thereof in preparing anti-tumor medicament
  • Isoalantolactone amino derivative and application of salt thereof in preparing anti-tumor medicament

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Embodiment 2

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Abstract

The invention relates to an isoalantolactone amino derivative and application of a salt thereof in preparing an anti-tumor medicament. The isoalantolactone amino derivative has a structure shown as a general formula (I), wherein R1 is the same as or different from R2; R1 or R2 independently represents a hydrogen atom, straight-chain or branched-chain C1 to C6 alkyl, C2 to C6 alkyl or acyl, C1 to C6 alkoxy carbonyl, aryl or heteroaryl; or R1, R2 and a nitrogen atom which connects R1 with R2 jointly form a ternary, quaternary, quintuple, hexahydric or heptabasic ring which contains one or more of C, N, O and S atoms; the salt refers to hydrochloride, hydrobromide, sulfate, phosphate, mesylate, fumarate, succinate, benzoate, acetate, malonate, malate, citrate, tartrate or maleate.

Description

technical field The present invention relates to the application of the amino derivatives of isogastrolides and their salts in the preparation of antitumor drugs. Background technique Tumor is a common and frequently-occurring disease, among which malignant tumors are a great threat to human health, and the number of people who die of cancer in the world reaches 6.3 million every year. Therefore, the research and development of anticancer drugs is a very challenging and significant field in today's life sciences. At present, the drugs used clinically to treat malignant tumors such as esophageal cancer, gastric cancer, and gynecology, because they inhibit the proliferation of cancer cells, but also indiscriminately inhibit the proliferation of bone marrow and other cells, thus generally have the problem of high toxicity and side effects. At present, there is an urgent expectation that researchers can develop anti-cancer drugs with low toxicity and high selectivity. The app...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/519A61K31/506A61K31/5377A61P35/00
Inventor 刘华
Owner 刘华
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