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Medicinal composition for treating ophthalmic inflammation and application thereof

A composition and drug technology, applied in the field of pharmacy, can solve the problems of unclear process parameters of collagen, infeasibility, incapability of enzymatic hydrolysis, etc.

Inactive Publication Date: 2010-02-17
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the patent application for collagen eye drops (publication number CN1927391A), the collagen used has no clear active ingredient group, and the process parameters are not clear when preparing collagen, which leads to unclear effective parts. ; Adopt pepsin or papain to carry out enzymolysis in this patent application, because pepsin enzymolysis specific limitation, it can not enzymolyze the proline peptide bond in the collagen, that is to say that pepsin can't enzymatically decompose collagen into Collagen, so the collagen described in this patent application is not collagen in the actual sense (relative molecular weight is not higher than 100kD), so this patent application is not feasible; in the patent application for composite collagen eye drops ( Publication No. CN1927392A) added chemical medicine antibiotics to be used in conjunction with collagen, but the active ingredient group of collagen was also not clear, confusing the concept of collagen and collagen
It can be seen that the prior art does not really solve the technical problems of collagen in ophthalmic medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Prescription: Moxifloxacin Hydrochloride 5g Collagen Extract 100ml (Containing Collagen 8g)

[0091] Preparation method: Add boric acid and borax to 2700ml of water for injection, heat to boil, cool to 80°C, add moxifloxacin hydrochloride and collagen extract, cool down to 60°C while stirring, then add 1.5g of ethylparaben, And add water for injection to 3000ml, stir evenly, pass through a microporous membrane (0.22 μm), and aseptically dispense, to obtain. (Note: The collagen used is donkey-hide gelatin biomimetic hydrolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 5kD ultrafiltration membrane)

Embodiment 2

[0093] Prescription: sulfacetamide sodium 30g collagen extract 375ml (containing 30g collagen)

[0094] Sodium Hyaluronate 1g Collagen Extract 30ml (Containing 1.5g Collagen)

[0095] Preparation method: Take 1500ml of water for injection, add chlorobutanol, put it in a boiling water bath, stir until clear, let it cool, add boric acid and borax, stir to dissolve, add 3g of hydroxypropyl beta cyclodextrin, mix well, Add sodium sulfacetamide, collagen extract, and collagen extract under stirring, mix well, filter, add water for injection to 2000ml, add sodium hyaluronate, fully swell, stir well, pass through a microporous membrane (0.22 μm ), aseptically dispensed, ready to use. (Note: The collagen used is pig skin biomimetic enzymolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 10kD ultrafiltration membrane; the collagen is made of pig bone and bovine bone, and the pH is adjusted to 6.0-7.0 with citric acid , prepared by enzymatic hydrolysis o...

Embodiment 3

[0097] Prescription: Netilmicin Sulfate 5g Collagen Extract 50ml (Contains Collagen 4g)

[0098] Preparation method: Add phenoxyethanol to 1000ml of water for injection heated to about 80°C, stir well, add boric acid and borax while hot, stir to dissolve, let cool, add netilmicin sulfate, stir until completely dissolved, Add collagen extract, add water for injection to 2000ml, filter through a microporous membrane (0.22μm), heat the filtrate to 50°C, add hypromellose (50k~70kmpa·s) while it is hot, and stir until At room temperature, add water for injection to 2000g, stir well to form a uniform gel, filter (0.80μm), and aseptically dispense to obtain. (Note: The collagen used is obtained from pigskin and cowhide after enzymatic hydrolysis with pepsin and papain, and then ultrafiltration with a 100kD ultrafiltration membrane)

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PUM

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Abstract

The invention discloses a Chinese medicinal composition for treating ophthalmic inflammation, which consists of collagen and Chinese medicaments for resisting bacterium and diminishing inflammation, and belongs to the field of pharmacy. Raw material medicaments of effective components of the medicinal composition comprise collagen and medicaments for resisting bacterium and diminishing inflammation such as erythrocin, ciprofloxacin, moxifloxacin, levofloxacin and the like which are prepared into various eye preparations by combining the prior art. The technical scheme creatively combines and applies the collagen and the effective components of the medicaments in the eye preparations so as to enlarge the application range of the collagen and achieve remarkable effect in the aspect of treating various ophthalmic inflammations.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating ophthalmic inflammation, which is composed of collagen and antibacterial and anti-inflammatory drugs, and belongs to the field of pharmacy. Background technique [0002] Ophthalmic inflammation accounts for a relatively large proportion of ophthalmic diseases. At present, conjunctivitis, keratitis, trachoma, blepharitis, blepharitis, scleritis, lacrimal gland inflammation, dacryocystitis and corneal ulcer are common clinically. . Ophthalmic inflammatory lesions have brought great suffering to the majority of patients. Chemical drugs have a good curative effect in the treatment of ophthalmic inflammation and have played a certain therapeutic role. [0003] Collagen is a peptide-containing substance produced by hydrolysis or enzymolysis of animal skin, bone or Achilles tendon. It is an important protein that composes animal connective tissue. In addition to 60-70% water in connective tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/39A61P27/02A61P31/04
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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