Medicinal composition for treating ophthalmic inflammation and application thereof
A composition and drug technology, applied in the field of pharmacy, can solve the problems of unclear process parameters of collagen, infeasibility, incapability of enzymatic hydrolysis, etc.
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Embodiment 1
[0090] Prescription: Moxifloxacin Hydrochloride 5g Collagen Extract 100ml (Containing Collagen 8g)
[0091] Preparation method: Add boric acid and borax to 2700ml of water for injection, heat to boil, cool to 80°C, add moxifloxacin hydrochloride and collagen extract, cool down to 60°C while stirring, then add 1.5g of ethylparaben, And add water for injection to 3000ml, stir evenly, pass through a microporous membrane (0.22 μm), and aseptically dispense, to obtain. (Note: The collagen used is donkey-hide gelatin biomimetic hydrolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 5kD ultrafiltration membrane)
Embodiment 2
[0093] Prescription: sulfacetamide sodium 30g collagen extract 375ml (containing 30g collagen)
[0094] Sodium Hyaluronate 1g Collagen Extract 30ml (Containing 1.5g Collagen)
[0095] Preparation method: Take 1500ml of water for injection, add chlorobutanol, put it in a boiling water bath, stir until clear, let it cool, add boric acid and borax, stir to dissolve, add 3g of hydroxypropyl beta cyclodextrin, mix well, Add sodium sulfacetamide, collagen extract, and collagen extract under stirring, mix well, filter, add water for injection to 2000ml, add sodium hyaluronate, fully swell, stir well, pass through a microporous membrane (0.22 μm ), aseptically dispensed, ready to use. (Note: The collagen used is pig skin biomimetic enzymolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 10kD ultrafiltration membrane; the collagen is made of pig bone and bovine bone, and the pH is adjusted to 6.0-7.0 with citric acid , prepared by enzymatic hydrolysis o...
Embodiment 3
[0097] Prescription: Netilmicin Sulfate 5g Collagen Extract 50ml (Contains Collagen 4g)
[0098] Preparation method: Add phenoxyethanol to 1000ml of water for injection heated to about 80°C, stir well, add boric acid and borax while hot, stir to dissolve, let cool, add netilmicin sulfate, stir until completely dissolved, Add collagen extract, add water for injection to 2000ml, filter through a microporous membrane (0.22μm), heat the filtrate to 50°C, add hypromellose (50k~70kmpa·s) while it is hot, and stir until At room temperature, add water for injection to 2000g, stir well to form a uniform gel, filter (0.80μm), and aseptically dispense to obtain. (Note: The collagen used is obtained from pigskin and cowhide after enzymatic hydrolysis with pepsin and papain, and then ultrafiltration with a 100kD ultrafiltration membrane)
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