Medicinal composition for preventing or treating metabolic syndrome

A pharmaceutical preparation and preparation technology, applied in the field of pharmacy, can solve the problems of vitamin folic acid deficiency, elevated plasma homocysteine, Hcy accumulation, etc.

Active Publication Date: 2007-01-10
SHENZHEN AUSA PHARM CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] Insufficient intake of folic acid, vitamin B12, and vitamin B6 in the body can cause vitamin folic acid deficiency in the body, and vitamin B12 and vitamin B6 are the coenzymes of cystathionine β synthase and methionine synthase respectively, and folic acid is the indirect donor of methyl groups in the body , the lack of the two not only hinders the resynthesis of methionine, but also causes the accumulation of Hcy and the increase of plasma homocysteine, which leads to the occurrence of homocysteinemia and cardiovascular related diseases, which seriously threatens life body health

Method used

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  • Medicinal composition for preventing or treating metabolic syndrome
  • Medicinal composition for preventing or treating metabolic syndrome
  • Medicinal composition for preventing or treating metabolic syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 prepares compound metformin folic acid (0.4mg) sheet (1000 pieces amount)

[0044] Formula: Metformin 250g

[0045] Folic acid 0.4g

[0046] Starch 100g

[0047] Microcrystalline Cellulose 50g

[0048] Sodium carboxymethyl starch 20g

[0049] Low-substituted hydroxypropyl cellulose 20g

[0050] Proper amount of povidone ethanol solution

[0051] Magnesium Stearate 1%

[0052]Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 250g of metformin and 0.4g of folic acid and mix them uniformly according to the method of equal increase, add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the prescription amount, mix evenly according to the method of equal increase, and use 5% povidone K29 / 30-95% ethanol solution to make soft material, granulate with 20-mesh sieve, dry at 40°C for about 2 hours, granulate with 20-...

Embodiment 2

[0053] Embodiment 2 prepares compound metformin folic acid (0.8mg) sheet (1000 pieces amount)

[0054] Formula: Metformin 250g

[0055] Folic acid 0.8g

[0056] Starch 100g

[0057] Microcrystalline Cellulose 50g

[0058] Sodium carboxymethyl starch 20g

[0059] Low-substituted hydroxypropyl cellulose 20g

[0060] Proper amount of povidone ethanol solution

[0061] Magnesium Stearate 1%

[0062] The preparation method is the same as that in Example 1, and each of the prepared compound tablets contains 250 mg of metformin and 0.8 mg of folic acid, with a mass ratio of 250:0.8.

Embodiment 3

[0063] Embodiment 3 prepares compound metformin folic acid (1.0mg) sheet (1000 pieces amount)

[0064] Formula: Metformin 250g

[0065] Folic acid 1.0g

[0066] Starch 100g

[0067] Microcrystalline Cellulose 50g

[0068] Sodium carboxymethyl starch 20g

[0069] Low-substituted hydroxypropyl cellulose 20g

[0070] Proper amount of povidone ethanol solution

[0071] Magnesium Stearate 1%

[0072] The preparation method is the same as that in Example 1, and each of the prepared compound tablets contains 250 mg of metformin and 1.0 mg of folic acid, with a mass ratio of 250:1.

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Abstract

The present invention relates to a medicine, preparation for preventing and curing metabolic syndrome. Said oral preparation includes biguanide sugar-reducing medicine or its medicinal salt, vitamins B or its related compound with similar bio-activity and medicinal carrier or excipient. Besides, said invention also provides its preparation method and concrete steps.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation containing biguanide hypoglycemic drugs and B vitamins, and the use of the preparation in preventing or treating living bodies suffering from metabolic syndrome (metabolic syndrome, MS). The present invention belongs to the field of pharmacy. Background technique [0002] In 1988, American scholar Reaven called the phenomenon that obesity, type 2 diabetes, dyslipidemia, hypertension, hyperinsulinemia, and coronary heart disease tend to occur in the same patient as "Syndrome X". Cardiovascular risk factor syndrome", "insulin resistance syndrome" and other names. In 1999, the World Health Organization (WHO) recommended the use of "metabolic syndrome (metabolic syndrome, MS)". On April 13-16, 2005, the 1st International Conference on Prediabetes and Metabolic Syndrome (The 1 st International Congress on Prediabetes and the Metabolic Syndrome) promulgated the definition of metabolic syndrome: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/519A61K31/155A61K9/20A61K9/22A61K9/48A61K9/52A61P3/10A61P3/04A61P3/06A61P9/12
Inventor 戴成祥王文艳李华于多王燕邢厚恂陈光亮徐希平
Owner SHENZHEN AUSA PHARM CO LTD
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