Preparation method and application of pogostemon cablin extracting solution

The technology of patchouli and extract is applied in the field of preparation of patchouli extract, and can solve the problems of patchouli's insulin resistance disease and the like that have not yet been found.

Inactive Publication Date: 2020-04-07
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, there is no report on the use of patchouli or its extracts for insulin resistance diseases

Method used

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  • Preparation method and application of pogostemon cablin extracting solution
  • Preparation method and application of pogostemon cablin extracting solution
  • Preparation method and application of pogostemon cablin extracting solution

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Embodiment Construction

[0012] A kind of preparation method of patchouli extract, specific steps are as follows: add 10 times of distilled water to soak overnight in the patchouli Chinese herbal decoction pieces (purchased from Daqing Furuibang pharmacy), and then heat to a slight boil, and the slightly boiled state is : There are a small amount of air bubbles coming out of the bottom of the pot. The state at this time can reduce the evaporation of water, which is conducive to the decoction of active ingredients; maintain a slight boil for 50 minutes and filter to obtain Chinese medicine liquid Ⅰ, add the remaining medicinal residues to 8 times the amount of distilled water , kept boiling slightly for 30 minutes, and then filtered to obtain Chinese medicinal liquid II. Combined traditional Chinese medicinal liquid I and Chinese medicinal liquid II, concentrated at 90°C to a crude drug concentration of 500 mg / mL, cooled to room temperature, and filtered through a 0.22 μm filter to obtain Guang Huoxiang...

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Abstract

The invention discloses a preparation method and application of a pogostemon cablin extracting solution, and relates to a preparation method and application of a traditional Chinese medicine preparation. The preparation method comprises the following specific steps: adding 10 times of distilled water into the pogostemon cablin traditional Chinese medicine decoction pieces and soaking overnight; heating to micro-boiling, keeping micro-boiling for 50 min and then filtering to obtain a traditional Chinese medicine liquid I; adding 8 times amount of distilled water into the remaining herb residue,keeping micro-boiling for 30 min, filtering to obtain a traditional Chinese medicine liquid II, mixing the traditional Chinese medicine liquid I and the traditional Chinese medicine liquid II, concentrating at 90 DEG C until the crude drug concentration is 500 mg / mL, cooling to room temperature, filtering by using a 0.22 um filter to obtain a pogostemon cablin extracting solution, and storing at4 DEG C for later use. The pogostemon cablin extracting solution prepared by the method has the effects of improving the insulin resistance status of 3T3-L1 adipose cells and enhancing the glucose uptake and utilization capacity of the adipose cells, and it is shown from the in-vitro cell level that pogostemon cablin has the effect of improving insulin resistance.

Description

Technical field: [0001] The invention relates to a preparation method and application of a traditional Chinese medicine preparation, in particular to a preparation method and application of patchouli extract. Background technique: [0002] Diabetes is the most common chronic disease. According to statistics, about 451 million people worldwide suffer from diabetes in 2017, and the prevalence of adult diabetes is as high as 8.4%. There are two main types of diabetes: type 1 diabetes (insulin-dependent) and type 2 diabetes (non-insulin-dependent). The former is caused by the failure of pancreatic β-cells and the absolute lack of insulin secretion; the latter is caused by relative insulin deficiency and Insulin resistance (IR), of which type 2 diabetes accounts for more than 90%. Insulin resistance (IR) is the pathological basis of type 2 diabetes, and it is mainly manifested in the three peripheral tissues of fat, liver and skeletal muscle, among which fat is the first place ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61P5/50
CPCA61K36/532A61K2236/331A61K2236/39A61P5/50
Inventor 徐闯崔一喆高海云
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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