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Application of patchouli alcohol in preparation of drug or health-caring product for male sexual dysfunction

A technology of patchouli alcohol and sexual function, applied in the field of biomedicine, can solve problems such as erectile dysfunction research and reports that have not yet been seen, and achieve good promotion and application prospects, high safety, and good prevention and treatment effects

Active Publication Date: 2015-02-04
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, patchouli alcohol has become a research hotspot of natural products at home and abroad, but there are no related studies and reports on its prevention and treatment of erectile dysfunction

Method used

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  • Application of patchouli alcohol in preparation of drug or health-caring product for male sexual dysfunction
  • Application of patchouli alcohol in preparation of drug or health-caring product for male sexual dysfunction
  • Application of patchouli alcohol in preparation of drug or health-caring product for male sexual dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Effect of Patchouli Alcohol on Erectile Function of Conscious Rats

[0035] 1. Materials and methods

[0036] (1) Animals and experimental devices

[0037] Male Wistar rats were selected. During the experiment, the rats were placed in a glass experimental device, the environment was kept quiet and the light was dim, and camera equipment was installed.

[0038] (2) Experimental grouping

[0039] ① Matrix control group: matrix (polyoxyethylene hydrogenated castor oil RH40);

[0040] ② Positive control group: apomorphine (APO), 100 μg / kg;

[0041] ③ Patchouli alcohol 5mM group: matrix + 5mM patchouli alcohol

[0042] ④ Patchouli alcohol 50mM group: matrix + 50mM patchouli alcohol.

[0043] There were 10 rats in each group, and 4 rats were randomly selected for each experiment and assigned to the above 4 groups.

[0044] (3) Administration method: smear 0.5mL drug on the penis and scrotum of rats.

[0045] 2. Results

[0046] Observe 60 minutes after adm...

Embodiment 2

[0051] Example 2 Effect of patchouli alcohol on penile erectile function in ED rats

[0052] 1. Materials and methods

[0053] (1) Animals and experimental devices

[0054] Male Wistar rats were selected, and the internal iliac artery was ligated with double guillotine according to the literature, and the rat model of vascular erectile dysfunction was reproduced. During the experiment, the rats were placed in the glass experimental device, the environment was kept quiet and the light was dim, and the camera equipment was installed.

[0055] (2) Experimental grouping:

[0056] ① Sham operation group: intragastric administration of distilled water;

[0057] ② Model control group: gavage with distilled water;

[0058] ③ Positive control group: 3 mg / kg Sidenafil by intragastric administration;

[0059] ④ Patchouli alcohol low dose group: intragastric administration of 10 mg / kg patchouli alcohol;

[0060] ⑤ Patchouli alcohol medium dose group: intragastric administration of...

Embodiment 3

[0069] Example 3 Relaxation effect of patchouli alcohol on corpus cavernosum of male rat penis

[0070] 1. Materials and methods

[0071] (1) Reagents

[0072] Krebs solution (Krebs’ Buffer) is freshly prepared, and its components and concentrations are as follows: sodium chloride (NaCl) 118mmol / L, potassium chloride (KCl) 4.75mmol / L, magnesium sulfate (MgSO 4 ) 1.18mmol / L, potassium dihydrogen phosphate (KH 2 PO 4 ) 1.18mmol / L, sodium bicarbonate (NaHCO 3 ) 24.8mmol / L, glucose (C 6 h 12 o 6 ) 10.0mmol / L, calcium chloride (CaCl 2 ) 2.5mmol / L, and the pH value is 7.40.

[0073] Patchouli alcohol was formulated into different concentrations with Krebs solution (10 -7 ~10 -4 M) Spare.

[0074] (2) Experimental device

[0075] The organ incubation tank was filled with freshly prepared Krebs solution, and the water heated by the constant temperature water tank was circulated in the water bath jacket of the incubation tank to maintain the temperature of the Krebs solu...

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Abstract

The invention discloses an application of patchouli alcohol in preparation of a drug or a health-caring product for male sexual dysfunction and discloses that the patchouli alcohol has a treating function on a vascular ED rat model, can significantly reduce an erection incubation period and increase erection times of ED rats and has a dose-dependent effect. Meanwhile, the invention discloses a mechanism of the patchouli alcohol in treatment of the male sexual dysfunction, namely, the patchouli alcohol can enhance a diastolic function of penis smooth muscle and can promote NO releasing level of penis vascular smooth muscle, thereby causing relaxation of cavernous body, which is different from other conventional medicine for treating the male sexual dysfunction. The invention provides a new medicinal application of the patchouli alcohol, provides a new medicine for the male sexual dysfunction and further provides a new preventing and treating approach for the male sexual dysfunction. In addition, the invention also proves that the patchouli alcohol not only is good in preventing and treating effect on the male sexual dysfunction but also is high in safety and practicability.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of patchouli alcohol in the preparation of male sexual dysfunction medicine or health products. Background technique [0002] Male erectile dysfunction (Erectile dysfunction, ED) refers to the inability of the penis to achieve or maintain a satisfactory sexual intercourse when the libido is normal. It is one of the most common male sexual dysfunction diseases and seriously affects the quality of sexual life. According to statistics, with the increase of age, the incidence of ED tends to increase. The incidence of ED in men reaches 15%, and it is as high as 65% in people over 65 years old. Sildenafil, which was officially launched in 1998, is a selective phosphodiesterase type 5 inhibitors (PDE5-Is), and is considered to be the first oral drug that can effectively treat ED. Currently, PDE5-Is has become the main drug for the treatment of ED. ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P15/10A23L1/29A23L33/00
CPCA23V2002/00A61K31/045A23V2200/30
Inventor 黄萍何学道谈博操红缨苏子仁赖小平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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